A5041571048- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Renal and related cancers
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Facial Nerve Paralysis Treatment and Research
- Ureteral procedures and complications
- Urologic and reproductive health conditions
- Genetic and Kidney Cyst Diseases
- Epigenetics and DNA Methylation
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Pediatric Urology and Nephrology Studies
- Urinary Bladder and Prostate Research
- Traumatic Ocular and Foreign Body Injuries
- Inflammatory Biomarkers in Disease Prognosis
- Migraine and Headache Studies
- Autophagy in Disease and Therapy
- Trigeminal Neuralgia and Treatments
- Gynecological conditions and treatments
- Multiple and Secondary Primary Cancers
Seoul National University Hospital
2022-2025
Seoul National University
2023
Yonsei University
2015-2022
Severance Hospital
2017-2021
Seoul Veterans Hospital
2009-2015
Gwangju University
2008
Abstract Background Autophagy is elevated in metastatic tumors and often associated with active epithelial‐to‐mesenchymal transition (EMT). However, the extent to which EMT dependent on autophagy largely unknown. This study aimed identify mechanisms by facilitates EMT. Methods We employed a liquid chromatography‐based metabolomic approach kirsten rat sarcoma viral oncogene ( KRAS ) liver kinase B1 LKB1 gene co‐mutated (KL) cells that represent an autophagy/EMT‐coactivated invasive lung...
This study investigated the safety and efficacy of HyperQure™ extravascular renal denervation (RDN) system in a swine model mild hypertension. Ten female pigs were fed 3% salt diet to induce hypertension underwent either RDN using (n = 7) or sham procedure 3). Blood pressure (BP) was continuously monitored implanted transmitters, assessments conducted via computed tomography angiography (CTA) at 28 days post-procedure. The primary endpoint change systolic blood (SBP) four weeks, while...
Previous studies using the Vesical Imaging Reporting and Data System (VI-RADS) to predict muscle-invasive bladder cancer (MIBC) had some limitations. Most were performed with transurethral resection of tumor (TUR-BT) specimens few samples. This study was conducted address these shortcomings confirm accuracy VI-RADS for cancer.This used data from Seoul National University Prospectively Enrolled Registry Urothelial Cancer-Radical Cystectomy (SUPER-UC-Cx). Patients who underwent multiparametric...
Abstract Background The polygenic risk score (PRS) is used to predict the of developing common complex diseases or cancers using genetic markers. Although PRS in clinical practice breast cancer risk, it more accurate for Europeans than non-Europeans because sample size training genome-wide association studies (GWAS). To address this disparity, we constructed a model predicting renal cell carcinoma (RCC) Korean population. Results Using GWAS analysis, identified 43 Korean-specific variants...
Abstract Background In the United States, rate of benign histology among resected renal tumors suspected to be malignant is increasing. We evaluated rates in Republic Korea and assessed racial effect using recent multi-institutional Korean-United States data. Methods conducted a retrospective study 11,529 patients (8,812 from The 2,717 States) compared between two countries. To evaluate effect, we divided into Korean, Asian US, Non-Asian US. Results small masses Korean were significantly...
Purpose This study was conducted to evaluate colic pain as a prognostic pretreatment factor that can influence ureter stone clearance and estimate the probability of stone-free status in shock wave lithotripsy (SWL) patients with stone. Materials Methods We retrospectively reviewed medical records 1,418 who underwent their first SWL between 2005 2013. Among these patients, 551 had measuring 4–20 mm were thus eligible for our analyses. The chief complaint defined either subjective flank...
Abstract Background Non-muscle invasive bladder cancer can be controlled by transurethral resection of (TURB), but suffers from frequent recurrences in 60–70% cases. Although, recurrence interval after TURB influences treatment course and prognosis, its implication risk factors have not been fully elucidated. We evaluated the early (within 1 yr) late (after pTa clinical significance on disease progression overall survival. Methods In this study, patients enrolled prospective patient registry...
Purpose: The use of gallium-68 prostate-specific membrane antigen-11 positron emission tomography/computed tomography (Ga-68 PSMA-11 PET/CT) is becoming increasingly common among men with prostate cancer (PCa). However, it remains uncertain which patients will derive the most benefit, and there a scarcity real-world data regarding its impact on altering treatment plans. This study investigated would benefit from Ga-68 PET/CT, focusing detection rates changes in strategies, drawing...
In patients with metastatic renal cell carcinoma (mRCC), sites of involvement have been reported to be associated a difference in survival. However, the frequency and survival according different metastases Korean mRCC remain unclear. Therefore, this study aimed assess site association between mRCC.
Background The effect of anesthesia methods on non-muscle invasive bladder cancer (NMIBC) recurrence post-resection remains uncertain. We aimed to compare the oncological outcomes spinal (SA) and general (GA) in patients with NMIBC. Methods This prospective randomized controlled trial recruited 287 clinical NMIBC at Seoul National University Hospital from 2018 2020. underwent transurethral resection tumor within 4 weeks randomization. Intrathecal hyperbaric bupivacaine (0.5%) a mixture...
Objectives There is no consensus on the management plan for incidental prostate cancer (IPCa) after holmium laser enucleation of (HoLEP). This study aims to investigate natural course this disease and suggest appropriate treatment in real clinical practice. Methods The medical records a prospective cohort patients with LUTS/BPH who underwent HoLEP between July 2008 December 2020 at Seoul National University Hospital were retrospectively reviewed. Patients palliative purpose control excluded....
Contemporary treatment strategies for localized prostate cancer (PCa) have been evolved over time. However, there is little data regarding survival outcomes based on initial by risk group in this new era. This study aims to evaluate among men who underwent observation, radiotherapy, or radical prostatectomy PCa using a population-based cohort.The Surveillance, Epidemiology, and End Results (SEER) with watchful waiting dataset (2010-2016) was used. We included diagnosed clinical stage...
Abstract Background Clear cell papillary renal tumor (CCPRCT) was first reported in 2006 a patient with end stage disease. After that it discovered the kidney without disease 2010s and started to be mentioned pathology urology. The incidence of CCPRCT is low most incidentally, so there lack reports on clinical characteristics surgical outcome. Methods This study used data from Seoul National University Prospectively Enrolled Registry for Renal Cell Carcinoma-Nephrectomy (SUPER-RCC-Nx)....
To assess the prognostic role of acidic urine (low pH) in upper tract urothelial cancer (UTUC).We reviewed patients enrolled Seoul National University Prospectively Enrolled Registry for Urothelial Cancer-Upper Tract Cancer (SUPER-UC-UTUC) who underwent surgical resection from March 2016 to December 2020 Hospital (SNUH). Patients with non-urothelial or those are condition at end-stage renal disease were excluded. Acidic was defined as pH ≤ 5.5.A total 293 a mean age 70.7 ± 9.5 years this...
Background Kidney tubular damage markers are biomarkers of acute or chronic kidney injury. Hypothetically, upper tract urothelial cancer (UTUC), which induces obstructive uropathy direct invasion the renal parenchyma, may also induce increased excretion urinary proteins. Therefore, this study aimed to investigate use biomarker as prognostic for UTUC. Methods The records 417 surgically resected patients with UTUC were obtained from Seoul National University Prospectively Enrolled Registry...
Extraperitoneal transvesicoscopic vesicovaginal fistula (VVF) repair has received limited use because of its narrow working space, longer operation time, and technical difficulty. The present study describes the feasibility robotic-assisted VVF in an animal model. Two Yorkshire swine underwent laparoscopic (RAL) repair. With 4 trocars, artificial was made supratrigonal area performed 3 layers as open methods. mean time 108 minutes. prolonged 1 case due to weak fixation bladder anterior...
About one-third of patients who undergo radical nephroureterectomy (RNUx) for upper tract urothelial carcinoma (UTUC) experience intravesical recurrence (IVR). This study investigated whether pyuria is a feasible predictor IVR after RNUx in with UTUC.Seven hundred forty-three UTUC underwent at single institute were analyzed this study. The participants divided into two groups: those without (non-pyuria) and pyuria. Kaplan-Meier survival analysis was performed, p-values assessed using the...
Lymphatic invasion in prostate cancer is associated with poor prognosis. However, there no consensus regarding the clinical and prognostic value of lymphatic invasion. This study aimed to investigate biochemical recurrence (BCR) compare rates between patients lymph node metastasis.We retrospectively analyzed 2,207 who underwent radical prostatectomy (RP) without pelvic dissection (PLND) 742 RP PLND for clinically localized or locally advanced cancer, 1993 2020, at Seoul National University...
As epithelial cells in the circulation are considered to originate from tumor, cell adhesion molecule has been commonly used as a standard marker for circulating tumor (CTCs) isolation. However, it seems disappear after epithelial-mesenchymal transition that most cancer undergo intravasation. Thus, more advanced techniques CTC detection needed better understand clinical significance of CTCs. A cell-specifically-infecting or replicating virus codes fluorescent monitor gene can be solution...