A5062189854- Plant-Microbe Interactions and Immunity
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Photosynthetic Processes and Mechanisms
- Genetic factors in colorectal cancer
- Fluorine in Organic Chemistry
- Heme Oxygenase-1 and Carbon Monoxide
- Pharmacogenetics and Drug Metabolism
- Chemical Reactions and Isotopes
- Helicobacter pylori-related gastroenterology studies
- Neonatal Health and Biochemistry
- Pancreatic function and diabetes
- Steroid Chemistry and Biochemistry
- Plant Stress Responses and Tolerance
- Analytical Chemistry and Chromatography
- Amino Acid Enzymes and Metabolism
- Chemical Synthesis and Analysis
- Antifungal resistance and susceptibility
- Multiple and Secondary Primary Cancers
- Plant Disease Resistance and Genetics
- Biochemical Acid Research Studies
- Gallbladder and Bile Duct Disorders
- Plant Pathogens and Fungal Diseases
- Plant responses to water stress
- Studies on Chitinases and Chitosanases
Nagoya University
2023-2024
Tokyo Metropolitan Geriatric Hospital
1980-1986
Stanford University
1983-1985
Kyushu University
1979-1983
Toranomon Hospital
1980
The University of Tokyo
1980
CALCIUM-DEPENDENT PROTEIN KINASE (CDPK) stimulates reactive oxygen species (ROS)-dependent signaling by activating RESPIRATORY BURST OXIDASE HOMOLOG (RBOH). The lysigenous aerenchyma is a gas space created cortical cell death that facilitates diffusion from the shoot to root tips. Previously, we showed RBOHH indispensable for induction of formation in rice (Oryza sativa) roots under low-oxygen conditions. Here, CDPK5 and CDPK13 localize plasma membrane where functions. Mutation analysis...
Histologic investigation and analysis of 370 polyps, removed via colonoscope, demonstrated a malignancy rate adenomas about 20 per cent. Even small under 1 cm in diameter were found to have higher malignant potential than previously appreciated. The was with increasing size, females had much males. It is obvious that colonoscopic polypectomy valuable detecting treating early carcinomas the colon.
We have used a monoclonal antibody specific for hydrocarbon-induced cytochrome P450 to localize, by electron microscopy, the epitope-specific P450. The was found in rough and smooth endoplasmic reticulum (ER) nuclear envelope of hepatocytes. Significant quantities were not Golgi stacks. also could find any evidence Golgi-associated processing Asn-linked oligosaccharide chains two well-characterized ER membrane glycoprotein enzymes (glucosidase II hexose-6-phosphate dehydrogenase), or...
Reactive oxygen species (ROS) are rapidly generated during plant immune responses by respiratory burst oxidase homolog (RBOH), which is a plasma membrane-localized NADPH oxidase. Although regulatory mechanisms of RBOH activity have been well documented, the ROS-mediated downstream signaling unclear. We here demonstrated that ROS sensor proteins play central role in via oxidative post-translational modification cysteine residues, sulfenylation. To detect protein sulfenylation, we used...
Hexose-6-phosphate dehydrogenase was purified from rat liver microsomal fraction more than 500-fold with a 45% recovery using DEAE-cellulose and 2',5'-ADP-Sepharose 4B columns. The enzyme appeared to be immunologically electrophoretically homogeneous had broad substrate cofactor specificities. activity not inhibited by p-chloromercuribenzoate. glycoprotein in nature, having Stokes radius of about 55 A, sedimentation coefficient 8.2 s, an isoelectric point 6.4. Minimum molecular weight the...
The hepatic microsomal haem oxygenase activity of rats treated with CoCl2 was studied kinetically by measuring biliverdin, the immediate product reaction. Biliverdin extracted diethyl ether/ethanol mixture, and determined difference between A690 A800. apparent Km value for NADPH (at 50 microM-haematin) about 0.2 microM when an NADPH-generating system used, whereas that NADH 630 microM. Essentially same Vmax. values were obtained both NADH- NADPH-dependent reactions. No synergism observed...
Three forms of cytochrome P-450 were purified to homogeneity from liver microsomes Wistar-strain rats treated with phenobarbital. They had minimum mol.wts. 52 000, 53 000 and 54 as determined by sodium dodecyl sulphate/polyacrylamide-gel electrophoresis are designated P-450(L), P-450(M) P-450(H) respectively. shown be immunoidentical Ouchterlony double-diffusion analysis. Several criteria, such isoelectric points, substrate specificities sensitivities tryptic digestion, however, indicated...
1. The microsomal haem oxygenase activity induced by the administration of CoCl2 was found mainly in smooth-surfaced fraction, whereas that untreated control animals widely distributed microsomal, rough-surfaced and Golgi fractions. 2. When preparation incubated time course distribution biliverdin between membranes medium followed, most formed first medium. This suggests active site is exposed on cytoplasmic surface membranes. possible localization enzyme at outer also supported a digestion...
An oxidative metabolism of glucose 6-phosphate was studied in rat liver microsomal fraction.Although radioactive 14C02 formed from [l-'4C]glucose the fraction (Hino, Y., and Minakami, S. (1982) J. Biochem.(Tokyo) 92, 547-557), formation negligible when [2-'4C]glucose used as a starting substrate.These results indicated an inability to rearrange form [1-I4C] 6-phosphate, it expected that certain compound derived accumulated end-product reaction.We, therefore, have tried identify product by...
Abstract Reactive oxygen species (ROS) are rapidly generated during plant immune responses by RBOH, which is a plasma membrane-localizing NADPH oxidase. Although regulatory mechanisms of RBOH activity have been well documented, the ROS-mediated downstream signaling unclear. We here demonstrated that ROS sensor proteins play central role in via oxidative post-translational modification cysteine residues, sulfenylation. To detect protein sulfenylation, we used dimedone, specifically and...
過去14年間の胃癌手術705例 (平均年齢75.8±7.6歳) において多重ロジスティクモデル分析を用いて縫合不全に対する術前・術中・術後因子の相対危険度を推定した. 有意の因子は術中の出血量および性別で, その他の因子はN.S.であった. 手術に対してリスクの高い高齢者, 特に男性においては術中の出血をでき得る限り少なくする努力をすることが縫合不全を防ぐ意味で重要となってくる.
The 12th iteration of the Japan-US Seminar in Plant Pathology was held Ithaca, New York at Cornell University fall 2022. Presentations covered a range topics under theme "Remodeling Plant-Microbe Environment During Disease, Defense, and Mutualism," meeting included panel discussion best practices science communication. This report presents highlights meeting, from perspective early career participants seminar. [Formula: see text] Copyright © 2023 Author(s). is an open access article...
目的, 方法: 後期老年者胃癌の形態学的特徴を検討するために, 老年者を前期, 中期, 後期に分け, 存在部位, 肉眼形態, 病理組織, 転移などを検討した. 男性の前期老年者96例, 110病巣, 中期104例, 120病巣, 後期25例, 31病巣, 女性の前期老年者51例, 55病巣, 中期91例, 106病単, 後期22例, 31病巣であった.結果: 加齢に伴い女性で多発癌の頻度が有意に増加していた. 早期癌では加齢に伴い隆起型が増加し, 表面陥凹型が減少していたが, 女性の表面陥凹型の減少が有意な変化であった. 進行癌では隆起型は中期老年者で増加していたが, 後期では減少していた. 組織型では女性で乳頭状腺癌が増加し, 低分化腺癌, 印環細胞癌が減少していたが, 印環細胞癌の減少が有意な変化であった. 加齢に伴い腹膜転移, 肝臓転移が増加していたが, 男性の後期老年者に肝臓転移が有意に多かった.
Abstract Bei der Dehydrierung Pregnant?one (I) mit Septomyxa af?nis entstehen hauptsächlich die beiden Steroide (II) und (III).
Abstract Das Diacetoxy‐pregnenon (I) wird über (II) und (III) in die Olefine (IV) (V) umgewandelt, von denen das Epoxid (VI) nur schlechter Ausbeute isoliert werden kann.
本研究の目的は, 老年者における十二指腸潰瘍の胃粘膜形態の特徴と, 臨床的特徴を明らかにすることにある.材料および方法: 60歳以上の連続剖検1,137例 (1968-1974) 中, 十二指腸潰瘍49例と, 無病変胃, 胃潰瘍, 胃ポリープの各群とを胃の形態および機能の面から比較検討した. さらに老年者十二指腸潰瘍切除10例を加えて発生誘因を主として調べた.結果: 胃底腺・幽門腺の境界の状態を, 小弯上で完全な胃底腺領域を残しているもの (いわゆる通常型 Ordinary pattern) と, 完全な胃底腺が消失してしまったもの (いわゆる萎縮型 atrophic とにわけた. 無病変胃では, 通常型は32.7%であるのに対し, 十二指腸潰瘍では79.5%と通常型が圧倒的に多い. これに対し胃潰瘍では通常型28.8%であり, ポリープでは7%を占めるにすぎない. 胃液検査でも, この形態的特徴を反映した結果が得られた.十二指腸潰瘍の発生誘因としては, 脳卒中, 重症感染, ショックなど stress ulcer とみなされるものや, 黄疸,...
60歳以上の不完全直腸脱35例と完全直腸脱26例について臨床的検討を行った.性別頻度について,不完全型は痔核の有無に関係なく男女ほぼ同頻度であったが,完全直腸脱は男4対女22と女性の方が多かった.最も長い病悩期間は,不完全型で痔核をもつもの30年,痔核をもたないもの7年,完全直腸脱19年であった.初回治療者は大部分が数年以内であった.主要症状は脱出感,出血と疼痛である.痔核をもつ不完全型は有痛例が多く,痔核をもたないもの,完全型では少い.前立腺肥大,慢性気管支炎,便秘など腹圧上昇を伴う併存疾患との相関はみられなかった.衰弱した高齢者では,簡単な術式を採用すべきである.著者らは不完全直腸脱に対しては結紮切除法,完全直腸脱に対しては,開腹,直腸つり上げ,後方固定,腹膜形成(Sudeck変法)を採用している.手術例44例中4例に再発がみられた.
Abstract γ‐Cyclodextrin katalysiert die Hydrolyse von p‐Nitrophenylestern (I) langkettiger Säuren besser als kurzkettiger Säuren.