A5102896717- Cancer-related molecular mechanisms research
- Spine and Intervertebral Disc Pathology
- RNA modifications and cancer
- Spinal Fractures and Fixation Techniques
- RNA Research and Splicing
- Parallel Computing and Optimization Techniques
- Medical Imaging and Analysis
- Cancer-related gene regulation
- Interconnection Networks and Systems
- Distributed and Parallel Computing Systems
- Musculoskeletal pain and rehabilitation
- Distributed systems and fault tolerance
- Ferroptosis and cancer prognosis
- Radiomics and Machine Learning in Medical Imaging
- Cytokine Signaling Pathways and Interactions
- Cancer Immunotherapy and Biomarkers
- Cervical and Thoracic Myelopathy
- Total Knee Arthroplasty Outcomes
- Embedded Systems Design Techniques
- Rheumatoid Arthritis Research and Therapies
- Connective tissue disorders research
- Pelvic and Acetabular Injuries
- Advanced Technologies in Various Fields
- Galectins and Cancer Biology
- Autopsy Techniques and Outcomes
Guangxi Medical University
2024-2025
Capital Medical University
2024-2025
Lanzhou University Second Hospital
2021-2024
Southwest University of Science and Technology
2011-2024
Lanzhou University
2021-2024
Fifth Affiliated Hospital of Zhengzhou University
2024
China Tobacco
2020-2022
Gansu Provincial Center for Disease Control and Prevention
2021
Henan Provincial People's Hospital
2019-2021
Henan University
2020
Abstract Senile osteoporosis is mainly caused by osteoblasts attenuation, which results in reduced bone mass and disrupted remodeling. Numerous studies have focused on the regulatory role of m6A modification osteoporosis; however, most investigated differentiation marrow mesenchymal stem cells (BMSCs), while direct mechanism remains unknown. This study revealed that progression senile closely related to downregulation methyltransferase-like 3 (METTL3). Overexpression METTL3 inhibits...
Postmenopausal osteoporosis is a prevalent disease that affects the bone health of middle-aged and elderly women. The link between gut microbiota health, known as gut-bone axis, has garnered widespread attention.
ABSTRACT Background Iatrogenic cervical kyphosis (ICK) often requires complex anterior and posterior correction, which is associated with multiple complications. Consequently, there a need to investigate alternative treatment approaches that streamline the operative process markedly diminish postoperative This study, therefore, aimed evaluate feasibility efficacy of single‐stage controllable antedisplacement fusion (ACAF) in revision surgeries for ICK. Methods A retrospective review was...
To investigate the association of NUF2 expression with tumor prognosis and its regulatory role in microenvironment. We analyzed expression, prognostic value, is immune-related functions across different cancer types using datasets from Human Protein Atlas (HPA), TCGA, GTEx, CCLE, TIMER. RT-qPCR, Western blotting, immunohistochemistry were used to detect liver cell lines tissue blood samples patients cancer. GO, KEGG, GSEA analyses conducted explore molecular mechanisms related genes, a...
Rheumatoid arthritis (RA) is an autoimmune disease that affects individuals of all ages. The basic pathological manifestations are synovial inflammation, pannus formation, and erosion articular cartilage, bone destruction will eventually lead to joint deformities loss function. However, the specific molecular mechanisms synovitis tissue in RA still unclear. Therefore, this study aimed screen explore potential hub genes immune cell infiltration RA.Three microarray datasets (GSE12021,...
Abstract Mitochondrial metabolism has been shown to play a key role in immune cell survival and function, but mitochondrial creatine kinase 2 (CKMT2) relatively little studied about tumor immunity. We aimed explore the prognostic value of CKMT2 33 cancer types investigate its potential function. used range bioinformatics approaches carcinogenic multiple cancers. was lowly expressed 14 tissues highly 4 tissues. Immunohistochemical assays showed overexpression colon rectal cancer. positively...
Extracts from plants used in Chinese medicine can be good sources of fungicides for agricultural applications. In this study, we separated and identified antifungal compounds four traditional extracts evaluated their activities vitro vivo. vitro, honokiol extracted Artemisia argyi showed broad-spectrum antimicrobial mycelial inhibitory activity with EC50 the range 3.56 - 33.85 μg/mL against eight plant pathogens. q-PCR indicated that might induce cell cancerisation inhibit cellular...
Objective To compare the efficacy and safety of percutaneous transforaminal endoscopic discectomy (PTED) fenestration (FD) for posterior ring apophyseal fractures (PRAF). Methods This study was a retrospective cohort control study. A total 96 patients with lumbar PRAF who underwent surgical treatment at Henan Provincial People's Hospital University from September 2013 to December 2017 were retrospectively examined, which 51 treated by PTED 45 FD. The average age those in group 28.24 years,...
In clinical practice, alterations in the internal environment of type 2 diabetes can significantly affect bone quality. While increased risk fractures among diabetic patients is well-established, precise mechanisms by which hyperglycemia influences quality remain largely unclear. Western blotting, immunohistochemistry (IHC), and micro-CT were used to examine ferroptosis-related protein expression morphology changes tissues mice. The CCK8 assay determined optimal conditions for inducing...
Thread level speculation (TLS) is a promising way to enhance the performance of chip multiprocessor (CMP). Up now, effective time-accurate CMP simulator dedicated for TLS still in demand. This paper presents novel flexible "TLSim" thread speculation. By TLSim, special and credible program behavior architecture design features can be gained guide speculative multicore design. It illustrates programming model TLSim. Furthermore, it trades off several important factors coming architecture. The...
Attributes like texture, lobulation, malignancy, etc., are commonly used to describe the phenotype of a pulmonary nodule in computed tomography (CT) image, which can provide useful medical knowledge for identification early stage lung cancer. There may exist certain relations among these attributes, and some attributes naturally imply or boost others that have been less comprehensively exploited previous studies. In this paper, we explicitly model 11 nodules by way transfer learning extract...
To describe the rationale and application of triggered EMG (T-EMG) in intraoperative neurophysiological monitoring, to explore efficacy safety posterior percutaneous endoscopic cervical discectomy (PPECD) treatment spondylotic radiculopathy (CSR) under multimodal monitoring (IOM).This study was a retrospective cohort control study. The clinical data 74 patients with single-segment CSR from June 2015 August 2018 were analyzed retrospectively, whom 35 underwent IOM-assisted PPECD (T-EMG...
Background: Ewing sarcoma remains the second most prevalent primary aggressive bone tumor in teens and young adults. The aim of our study was to develop validate a web-based nomogram predict overall survival for children. Methods: A total 698 patients, with 640 cases from Surveillance, Epidemiology, End Results (the training set) 58 external validation set), were included this study. Cox analyses carried out determine independent prognostic indicators, which further establish nomogram....
This study explores the role of disulfidptosis in monocytes and its relation to postmenopausal osteoporosis (PMOP). Using single-cell RNA sequencing microarray assays, we identified key genes: LONRF1, ACAP2, IPO9, PGRMC2. Through differential analysis, Weighted Gene Co-expression Network Analysis (WGCNA), machine learning, these genes were linked PMOP. Functional enrichment ROC curve analysis demonstrated their effectiveness distinguishing fracture patients from healthy individuals. Notably,...