A5101888625- Redox biology and oxidative stress
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Bioactive Compounds and Antitumor Agents
- Graphene and Nanomaterials Applications
- Genomics, phytochemicals, and oxidative stress
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nanoplatforms for cancer theranostics
- Renal Diseases and Glomerulopathies
- Renal and related cancers
- Genetic and Kidney Cyst Diseases
- Heat shock proteins research
- Radiopharmaceutical Chemistry and Applications
- Ubiquitin and proteasome pathways
- Glutathione Transferases and Polymorphisms
- Enzyme function and inhibition
- Vitamin C and Antioxidants Research
- Circular RNAs in diseases
- Pediatric health and respiratory diseases
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- Antimicrobial Peptides and Activities
- Synthesis and Characterization of Heterocyclic Compounds
- Bone Tissue Engineering Materials
Henan University
2024-2025
Sichuan Academy of Traditional Chinese Medicine
2024
Central South University
2020-2024
Foshan University
2021-2024
Woosong University
2024
Beijing Institute of Technology
2024
Yulin University
2024
Shaanxi University of Chinese Medicine
2024
Northwestern Polytechnical University
2024
Chongqing University of Technology
2024
Recently, traditional Chinese medicine and medicinal herbs have attracted more attentions worldwide for its anti-tumor efficacy. Celastrol Triptolide, two active components extracted from the herb Tripterygium wilfordii Hook F (known as Lei Gong Teng or Thunder of God Vine), shown effects. was identified a natural 26 s proteasome inhibitor which promotes cell apoptosis inhibits tumor growth. The effect mechanism Triptolide on prostate cancer (PCa) is not well studied. Here we demonstrated...
Cancer cells from different origins exhibit various basal redox statuses and thus respond differently to intrinsic or extrinsic oxidative stress. These intricate characteristics condition the success of redox-based anticancer therapies that capitalize on ability reactive oxygen species achieve selective efficient cancer cell killing. Redox biology methods, stable isotope labeling by amino acids in culture (SILAC)-based proteomics, bioinformatics pattern comparisons were used decipher...
MicroRNA-21 (miR-21) is up-regulated in many cancers, including colorectal cancer (CRC). Nevertheless, the function of miR-21 CRC and mechanism underlying that still unclear. After analyzing expression Sec23A cell lines, we transfected highest expressing line, SW-480, with a plasmid containing an inhibitor lowest DLD-1, mimic measured effects on proliferation, migration, invasion. We also evaluated effect knocking down its Finally, assessed xenograft tumor model mice. Tumor tissues from...
Increasing evidences suggest that inducing mesenchymal stem cells to differentiate into osteoblasts has been as an especially important component in the prevention and therapy for degenerative bone disease. Here, we identify a novel lncRNA, linc02349, which increases significantly during osteogenic differentiation.Human umbilical cord-derived (hUC-MSCs) dental pulp were used. Overexpression knockdown of linc02349 cell lines generated using lentiviral-mediated gene delivery method....
Chronic obstructive pulmonary disease (COPD), a prevalent, progressive respiratory disease, has become the third leading cause of death globally. Increasing evidence suggests that intestinal and microbiota dysbiosis is associated with COPD. Researchers have shown T helper (Th) 17/regulatory (Treg) imbalance involved in Qibai Pingfei Capsule (QBPF) traditional Chinese medicine used to treat COPD clinically China. However, effects QBPF intervention on Th17/Treg balance gut lung are still...
Metformin has been reported to inhibit the growth of various types cancers, including prostate cancer. Yet mode anti-cancer action metformin and underlying mechanisms remain not fully elucidated. We hypothesized that antitumorigenic effects are mediated through upregulation pigment epithelium-derived factor (PEDF) expression in cancer cells. In this report, treatment significantly inhibited proliferation colony formation cells, a dose- time-dependent manner. Meanwhile, markedly suppressed...
Abstract Background Although the treatments of skin wounds have greatly improved with increase in therapeutic methods and agents, available interventions still cannot meet current clinical needs. Therefore, development new pro-regenerative therapies remains urgent. Owing to their unique characteristics, both nanomaterials peptides provided novel clues for however, more efforts were be awaited anticipated. Results In research, Hollow polydopamine (HPDA) nanoparticles synthesized HPDA loading...
A synergistic antibacterial system for polyglycolic acid scaffolds was constructed by cation exchange of montmorillonite (MMT) with Cu 2+ and then intercalation cetyltrimethylammonium bromide (CTAB) into the interlayer MMT.
Vascular cognitive impairment (VCI) encompasses a range of deficits arising from vascular pathology. The pathophysiological mechanisms underlying VCI remain incompletely understood; however, chronic cerebral hypoperfusion (CCH) is widely acknowledged as principal pathological contributor. Mitochondria, crucial for cellular energy production and intracellular signaling, can lead to numerous neurological impairments when dysfunctional. Recent evidence indicates that mitochondrial...
Carbon nanoparticles suspension injection (CNSI) has been widely used in tumor drainage lymph node mapping, and its new applications drug delivery, photothermal therapy, so on have extensively investigated. To develop clinical applications, the toxicity of CNSI after intravenous exposure should be thoroughly investigated to ensure safe use. Herein, we studied bioaccumulation reticuloendothelial system (RES) organs corresponding mice. After CNSI, no abnormal behavior mice was observed during...
Bone defects represent a significant orthopedic challenge, with associated disorders continue to pose clinical difficulties. In the biomedical field, advancements in three-dimensional (3D) printing technology have established bone tissue engineering (BTE) scaffolds as promising approach for effective treatment. These not only provide structural support cells but also serve templates guide regeneration. recent years, owing their exceptional physicochemical properties, two-dimensional...
Peroxiredoxin (Prx) 1 is a member of the thiol-specific peroxidases family and plays diverse roles such as H 2 O scavenger, redox signal transducer molecular chaperone. Prx1 has been reported to be involved in protecting cancer cells against various therapeutic challenges. We investigated how modulations intracellular system affect cell sensitivity reactive oxygen species (ROS)-generating drugs. observed that stable transient knockdown significantly enhanced HeLa β-lapachone (β-lap),...
Many promising anticancer molecules are abandoned during the course from bench to bedside due lack of clear-cut efficiency and/or severe side effects. Vitamin K3 (vitK3) is a synthetic naphthoquinone exhibiting significant in vitro and vivo activity against multiple human cancers, has therapeutic potential when combined with other molecules. The major mechanism for vitK3 generation cytotoxic reactive oxygen species (ROS). We thus reasoned that rational redox modulation cancer cells could...
Objective: In this study, we mainly explored two questions: Which microorganisms were functionally active in the endometrium of patients with endometrial cancer (EC)? What kind response did human host respond to microorganisms? Methods: Nine and eight normal subjects included study. HMP Unified Metabolic Analysis Network 3 (HUMAnN3) was used obtain functional information microorganisms. addition, metaCyc-based GSEA enrichment analysis on metabolic pathways host. At same time, O2PLS model...
Abstract: Carbon nanoparticles (CNPs) have been widely used in tumor drainage lymph node (TDLN) imaging, drug delivery, photothermal therapy, and so on. However, during the theranostic applications, accumulation efficiency of CNPs target organs is unknown yet, which largely hinders extension into clinical uses. Herein, we prepared skeleton-labeled 13 C-CNPs that had identical properties to commercial suspension injection (CNSI) for imaging quantification TDLN. were by arc discharge method,...
Addition of biochar and straw has constituted an effective way to improve soil fertility in tobacco fields. However, little is known about the effects these amendments on CH4 N2O emissions their potential microbial mechanisms. Here, we conducted experiment tobacco-planted using four treatments: mineral fertilizers only (F), with (BF), wheat (SF), + (BSF). Soil physical chemical parameters, nitrous oxide (N2O) methane (CH4) emissions, related microorganisms functional genes (pmoA, mcrA, amoA,...
Tryptanthrin (TRYP) is the main active ingredient in Indigo Naturalis. Studies have shown that TRYP had excellent anti-inflammatory activity, but its specific mechanism has been unclear. In this work, differentially expressed proteins resulting from intervention LPS-stimulated RAW264.7 cells were obtained based on tandem mass tag proteomics technology. The of was further validated by a combination experiments using LPS-induced cell model vitro and DSS-induced UC mouse (free drinking 2.5%...