A5101700593- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Chromosomal and Genetic Variations
- Identification and Quantification in Food
- Single-cell and spatial transcriptomics
- Agricultural Development and Management
- Plant Molecular Biology Research
- Plant nutrient uptake and metabolism
- Wheat and Barley Genetics and Pathology
- Plant Virus Research Studies
- Aquaculture Nutrition and Growth
- Genetics and Plant Breeding
- Eosinophilic Disorders and Syndromes
- Fish Ecology and Management Studies
- Protein Tyrosine Phosphatases
- RNA modifications and cancer
- Technology and Security Systems
- Reproductive biology and impacts on aquatic species
- Risk and Safety Analysis
- TGF-β signaling in diseases
- Cancer-related molecular mechanisms research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Extracellular vesicles in disease
Wuhan Textile University
2023-2025
Huazhong Agricultural University
2015-2024
Zhejiang Marine Fisheries Research Institute
2015-2023
Chengdu Third People's Hospital
2022-2023
Southwest Jiaotong University
2023
Shanghai Zhangjiang Laboratory
2023
First Affiliated Hospital of Zhengzhou University
2011
Sichuan Integrative Medicine Hosipital
2011
Sichuan University
2011
Maize is one of the most important crops globally, and it shows remarkable genetic diversity. Knowledge this diversity could help in crop improvement; however, gold-standard genomes have been elucidated only for modern temperate varieties. Here, we present a high-quality reference genome (contig N50 15.78 megabases) maize small-kernel inbred line, which derived from tropical landrace. Using haplotype maps B73, Mo17 SK, identified 80,614 polymorphic structural variants across 521 diverse...
Maize was domesticated from lowland teosinte (Zea mays ssp. parviglumis), but the contribution of highland mexicana, hereafter mexicana) to modern maize is not clear. Here, two genomes for Mo17 (a inbred) and mexicana are assembled using a meta-assembly strategy after sequencing 10 lines derived maize-teosinte cross. Comparative analyses reveal high level diversity between Mo17, B73, including three Mb-size structural rearrangements. The spontaneous mutation rate estimated be 2.17 × 10-8...
As one of the most extensively cultivated crops, maize (Zea mays L.) has been studied by researchers and breeders for over a century. With advances in high-throughput detection various omics data, wealth multi-dimensional multi-omics information accumulated its wild relative, teosinte. Integration this potential to accelerate genetic research generate improvements agronomic traits. To end, we constructed ZEAMAP, comprehensive database incorporating multiple reference genomes, annotations,...
Abstract Background Maize ( Zea mays L.) is at the vanguard facing upcoming breeding challenges. However, both a super pan-genome for genus and comprehensive genetic variation map maize are still lacking. Results Here, we construct an approximately 6.71-Gb pan- genome that contains around 4.57-Gb non-B73 reference sequences from fragmented de novo assemblies of 721 individuals. We annotate total 58,944 genes find 44.34% them dispensable in population. Moreover, 255,821 common structural...
Abstract Gene expression variation largely contributes to phenotypic diversity and constructing pan-transcriptome is considered necessary for species with complex genomes. However, the regulation mechanisms functional consequences of unexplored systematically. By analyzing RNA-seq data from 368 maize diverse inbred lines, we identified almost one-third nuclear genes under presence absence variation, which tend play regulatory roles are likely regulated by distant eQTLs. The ePAV was directly...
Flowering time is a trait vital to the adaptation of flowering plants different environments. Here, we report that CCT domain genes play an important role in maize (Zea mays L.). Among 53 family identified maize, 28 were located quantitative locus regions and 15 significantly associated with time, based on candidate-gene association mapping analysis. Furthermore, gene named ZmCOL3 was shown be repressor flowering. Overexpressing delayed by approximately 4 d, either long-day or short-day...
Abstract Despite its global importance as a crop with broad economic, dietary, and cultural importance, the origins of maize closest wild relatives remained topic vigorous debate for nearly century. Molecular analyses ultimately concluded that was domesticated once from common ancestor extant relative, lowland grass Zea mays ssp. parviglumis . But neither current genetic model nor earlier models based on archaeological data account totality available data, recent work has highlighted...
Extracellular vesicles (EVs) derived from pleural effusion (PE) is emerging as disease biomarkers. However, the methods for isolation of EVs PE (pEVs) were rarely studied. In our study, three isolating pEVs lung cancer patients compared, including ultracentrifugation (UC), a combination UC and size exclusion chromatography (UC-SEC) density gradient (UC-DGU). The subpopulation was identified by nanoparticle tracking analysis (NTA), transmission electron microscopy (TEM), Western blotting (WB)...
ABSTRACT Variation in gene expression contributes to the diversity of phenotype. The construction pan-transcriptome is especially necessary for species with complex genomes, such as maize. However, knowledge regulation mechanisms and functional consequences limited. In this study, we identified 13,382 nuclear presence absence variation candidates (ePAVs, expressed 5%~95% lines; based on reference genome) by re-analyzing RNA sequencing data from kernels (15 days after pollination) 368 maize...
Abstract As one of the most extensively cultivated crops, maize ( Zea mays L.) has been studied by researchers and breeders for over a century. With advances in high-throughput detection various omics data, wealth multi-dimensional multi-omics information accumulated its wild relative, teosinte. Integration this potential to accelerate genetic research generate improvements agronomic traits. To end, we constructed ZEAMAP http://www.zeamap.com ), comprehensive database incorporating multiple...
In traditional research, monitoring data and samples are limited, it is difficult to achieve ideal results in real-time rapid response environmental risks. By leveraging extensive gathered from nuclear power plants, the research employed machine learning methodologies for accurate feature selection extraction of parameters. An efficient risk assessment model was successfully established by using a random forest algorithm. The 95% confidence interval area under curve value spanned 0.6894...
<title>Abstract</title> A comprehensive understanding of inflorescence development is crucial for crop genetic improvement, as meristems give rise to reproductive organs and determine grain yield. However, dissecting at the cellular level has been challenging due lack distinct marker genes distinguish each cell types, particularly various types that are vital organ formation. In this study, we used spatial enhanced resolution omics-sequencing (Stereo-seq) construct a precise transcriptome...
Cell trajectory inference is very important to understand the details of tissue cell development, state differentiation and gene dynamic regulation. However, due high noise heterogeneity single-cell data, it challenging infer in complex biological processes. Here, we proposed a new method, called Metric Learning Bhattacharyya Kernel Feature Decomposition (MLBKFD). In MLBKFD, statistical model was used by calculating Markov transition matrix kernel between cells. Before that, expedite...
AbstractThe golden drum (Chrysochir aurenus) is an important food fish of Indo-West Pacific and China. To study the phylogenetic status, we sequenced complete mitochondrial genome C. aurenus. The mitogenome 16 505 bp in length composed 13 protein-coding genes, 2 rRNAs, 22 tRNAs, a control region. gene composition structural arrangement aurenus mtDNA were identical to most other vertebrates. analysis using revealed that might be grouped different genera Argyrosominae, but not belonged...
The blackspotted croaker (Nibea diacanthus) is an important food fish of Indo-West Pacific and China. To study the phylogenetic status, we sequenced complete mitochondrial genome N. diacanthus. mitogenome 16,532 bp in length composed 13 protein-coding genes, two rRNAs, 22 tRNAs, a control region. gene composition structural arrangement diacanthus mtDNA were identical to most other vertebrates. analysis using revealed that might be separated from Nibea genera Argyrosominae, which was...
Abstract Maize is a globally valuable commodity and one of the most extensively studied genetic model organisms. However, we know surprisingly little about extent potential utility variation found in wild relatives maize. Here, characterize high-density genomic map from 744 genomes encompassing maize all taxa genus Zea , identifying over 70 million single nucleotide polymorphisms (SNPs) nearly 9 Insertion/Deletion (InDel) polymorphisms. The reveals evidence selection within displaying novel...
The giant croaker Nibea japonica (Perciformes, Sciaenidae) is an important economic fish distributing in the East China Sea, South and Japan southern coast. In this study, complete mitochondrial genome of N. was firstly determined. It 16 496 bp-length consists 22 tRNA genes, 13 protein-coding two rRNA a control region. Except for eight ND6 all other genes are encoded on heavy strand. Phylogenetic analysis revealed that japonica, A. amoyensis, seven first clustered into Argyrosominae clade....
The cuneate drum, Nibea miichthioides, is a native sciaenid species with relevant commercial importance in China. However, the wild resource represented by this has been severely damaged owing to overfishing and water pollution. For conserving recovering through appropriate measures, genetic studies on population are necessary. complete mitochondrial genome of N. miichthioides supplement mitogenome database for giant croakers can be used address taxonomic problems phylogenetic relationships...