A5102721553- Infant Nutrition and Health
- Clinical Nutrition and Gastroenterology
- Neonatal Respiratory Health Research
- Intensive Care Unit Cognitive Disorders
- Vitamin C and Antioxidants Research
- Breastfeeding Practices and Influences
- Autoimmune and Inflammatory Disorders Research
- Global Security and Public Health
- Gallbladder and Bile Duct Disorders
- Adolescent and Pediatric Healthcare
- Diversity and Career in Medicine
- Historical and Religious Studies of Rome
- Amino Acid Enzymes and Metabolism
- Byzantine Studies and History
- Sleep and Wakefulness Research
- Polyamine Metabolism and Applications
- Pediatric Hepatobiliary Diseases and Treatments
- Infant Development and Preterm Care
- Sex and Gender in Healthcare
- Psychosocial Factors Impacting Youth
- COVID-19 epidemiological studies
- Vitamin K Research Studies
- Biliary and Gastrointestinal Fistulas
- Cellular transport and secretion
- Alcoholism and Thiamine Deficiency
University of Alabama at Birmingham
2022-2025
Northwell Health
2025
University of British Columbia
2023
Scripps Research Institute
2022
Spectrum Health
2020
Boston Children's Hospital
2000
University of California, Irvine
1998
Sepsis is a common syndrome with substantial morbidity and mortality. A combination of vitamin C, thiamine, corticosteroids has been proposed as potential treatment for patients sepsis.To determine whether hydrocortisone every 6 hours increases ventilator- vasopressor-free days compared placebo in sepsis.Multicenter, randomized, double-blind, adaptive-sample-size, placebo-controlled trial conducted adult sepsis-induced respiratory and/or cardiovascular dysfunction. Participants were enrolled...
Importance Sepsis is associated with long-term cognitive impairment and worse psychological functional outcomes. Potential mechanisms include intracerebral oxidative stress inflammation, yet little known about the effects of early antioxidant anti-inflammatory therapy on cognitive, psychological, outcomes in sepsis survivors. Objective To describe observed differences vitamin C, thiamine, hydrocortisone between intervention control groups Vitamin Thiamine, Steroids (VICTAS) randomized...
OBJECTIVES Enteral nutrition with unfortified human milk during the first 2 postnatal weeks often leads to cumulative protein and energy deficits among preterm infants. Fortified administered soon after birth could increase fat-free mass (FFM) improve growth in these METHODS This was a masked, randomized trial. Starting on feeding day 2, extremely infants 28 or younger fed maternal donor were receive either diet fortified human-based product (intervention group) standard, (control group)....
Rare diseases impact approximately 1 in 10 people worldwide, and yet, less than 5% of all rare currently have an approved treatment option available. This is due to many challenges unique diseases, including small, diverse patient populations, the cost drug development that not proportionate number patients who could potentially benefit from treatment, difficulty with clinical trial design validate new therapeutics. As a result, repurposing has become increasingly promising for finding...
Objective To characterise the effects of early and exclusive enteral nutrition with either maternal or donor milk in infants born very preterm (28 0/7 –32 6/7 weeks gestation). Design Parallel-group, unmasked randomised controlled trial. Setting Regional, tertiary neonatal intensive care unit. Participants 102 between 2021 2022 (51 each group). Intervention Infants to intervention group received 60–80 mL/kg/day within first 36 hours after birth. control 20–30 (standard trophic feeding...
Background : Gallstones and common bile duct calculi have been increasingly diagnosed in recent years infants children. The present study aims to review the spectrum of this disorder last two decades. Methods During period 1979–96 a total 102 consecutive children were Royal Alexandra Hospital for Children with gallstones or calculi. A detailed retrospective analysis follow‐up these form basis report. Results median age at presentation was 10 years. Recurrent right upper quadrant pain most...
Gender bias is behavior that shows favoritism towards one gender over another. Microaggressions are defined as subtle, often unconscious, discriminatory, or insulting actions communicate demeaning negative attitudes. Our objective was to explore how female otolaryngologists experience and microaggressions in the workplace.
Abstract Objective To assess changes in juvenile idiopathic arthritis (JIA) treatments and outcomes Canada, comparing 2005–2010 2017–2021 inception cohorts. Methods Patients enrolled within three months of diagnosis the Research Arthritis Canadian Children Emphasizing Outcomes (ReACCh-Out) Alliance Pediatric Rheumatology Investigators Registry (CAPRI) cohorts were included. Cumulative incidences drug starts outcome attainment 70 weeks compared with Kaplan–Meier survival analysis...
Previous studies have shown that experimentally induced lysosomal dysfunction elicits various features of aging in the cortical telencephalon. The present study used cultured slices to test if: (1) it causes similar changes hypothalamus, and/or (2) modifies processing two releasing factors important aging. A 2-day exposure N-CBZ-L-phenylalanyl-L-alanine-diazomethylketone (ZPAD), a selective inhibitor cathepsins B and L, triggered pronounced increase numbers lysosomes ventromedial dorsomedial...
Abstract INTRODUCTION Glioblastoma multiforme (GBM) is an aggressive brain cancer with dismal prognosis, despite surgery, radiation and chemotherapy. Therapies directed to the immune system are exciting prospect in oncology require understanding of interaction between tumors cells. Our objective was use computational tools estimate infiltration GBM determine whether specific cell types associated clinical outcomes. METHODS RNA sequencing targeted DNA (to 981 genes) performed from 37...
Background: Randomized trials have not reported the effects of early progression feeding volumes on fluid balance and neurodevelopment among infants born extremely preterm (≤28 weeks). Method: Fluid, electrolyte, data 60 randomly assigned to receive either 1 (early group) or 4 days (late trophic at 20–24 mL/kg/day were analyzed. Results: Infants randomized group received less parenteral fluids, generated lower urine volumes, had excessive weight loss during first 14 after birth. The 7-point...