A5090190295- Gut microbiota and health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Oral microbiology and periodontitis research
- Nutritional Studies and Diet
- Cancer-related molecular mechanisms research
- Clostridium difficile and Clostridium perfringens research
- Nosocomial Infections in ICU
- Respiratory and Cough-Related Research
- Antifungal resistance and susceptibility
- Single-cell and spatial transcriptomics
- Asthma and respiratory diseases
- Antibiotic Use and Resistance
- Diet and metabolism studies
- Tracheal and airway disorders
- MicroRNA in disease regulation
- Atherosclerosis and Cardiovascular Diseases
- Probiotics and Fermented Foods
- Transplantation: Methods and Outcomes
- Oral health in cancer treatment
- Metabolomics and Mass Spectrometry Studies
- Cancer Cells and Metastasis
- Head and Neck Cancer Studies
- Renal Diseases and Glomerulopathies
- Mycobacterium research and diagnosis
Southwest Jiaotong University
2025
Fujian Medical University
2022-2024
First Affiliated Hospital of Xiamen University
2021-2024
Zhujiang Hospital
2017-2023
Southern Medical University
2015-2023
Max Delbrück Center
2018-2023
Xiamen University
2021-2022
China Agricultural University
2021
Nanfang Hospital
2018-2020
University of Chinese Academy of Sciences
2016-2019
Background Three different cell types constitute the glomerular filter: mesangial cells, endothelial and podocytes. However, to what extent cellular heterogeneity exists within healthy populations remains unknown. Methods We used nanodroplet-based highly parallel transcriptional profiling characterize content of purified wild-type mouse glomeruli. Results Unsupervised clustering nearly 13,000 single-cell transcriptomes identified three known types. provide a comprehensive online atlas gene...
Oral mucositis is probably the most debilitating complication that can arise in treating a patient with head and neck cancer. Little known about impacts of oral microbiota on initiation progression mucositis.Based 16S rRNA gene sequencing, dynamic changes bacterial profile as well correlations between severity shifts during radiotherapy were investigated.Our results revealed community structure altered progressively radiation therapy, parallel marked increase relative abundance some...
Epithelial-to-mesenchymal transition (EMT) is a complex multistep process in which phenotype switches are mediated by network of transcription factors (TFs). Systematic characterization all dynamic TFs controlling EMT state transitions, especially for the intermediate partial-EMT state, represents highly relevant yet largely unexplored task. Here, we performed computational analysis that integrated time-course transcriptomic data with public cistromic and identified three synergistic master...
Physical exercise is commonly regarded as protective against cardiovascular disease (CVD). Recent studies have reported that alters the gut microbiota and modification of can influence cardiac function. Here, we focused on relationships among exercise, function after myocardial infarction (MI). Four-week-old C57BL/6J mice were exercised a treadmill for 4 weeks before undergoing left coronary artery ligation. Cardiac was assessed using echocardiography. Gut microbiomes evaluated post-exercise...
Abstract The competitive endogenous RNA (ceRNA) hypothesis suggests an intrinsic mechanism to regulate biological processes. However, whether the dynamic changes of ceRNAs can modulate miRNA activities remains controversial. Here, we examine dynamics during TGF-β-induced epithelial-to-mesenchymal transition (EMT). We observe that TGFBI, a transcript highly induced EMT in A549 cells, acts as ceRNA for miR-21 EMT. further identify FN1 miR-200c canonical SNAIL-ZEB-miR200 circuit MCF10A cells....
Background and aimsAlthough most risk factors for cardiac valve calcification (VC) are similar to those coronary artery disease (CAD), they differ regarding lesions clinical symptoms. Recently, increasing evidence suggests that intestinal bacteria play essential roles in cardiovascular (CVD). It is plausible the gut microbiota linked occurrence of different CVDs under factors. Thus, we aimed explore microbiomes patients with VC or CAD determine their underlying connections.MethodsWe...
Abstract Characterizing the complex composition of solid tumors is fundamental for understanding tumor initiation, progression and metastasis. While patient-derived samples provide valuable insight, they are heterogeneous on multiple molecular levels, often originate from advanced stages. Here, we use single-cell transcriptome epitope profiling together with pathway lineage analyses to study tumorigenesis a developmental perspective in mouse model salivary gland squamous cell carcinoma. We...
Little is known about the underlying airway microbiome diversity in chronic obstructive pulmonary disease (COPD) at in-depth taxonomic levels. Here we present first insights on COPD species and strain-levels. The full-length 16S rRNA gene was characterized from sputum 98 patients 27 age-matched healthy controls, using Pacific Biosciences sequencing platform. Individual within same genus exhibited reciprocal relationships with severity. Species dominant health can be taken over by another but...
Background and Aims: Little is known about diet-related inflammation in chronic obstructive pulmonary disease (COPD). In this study, we aimed to explore the association between COPD dietary inflammatory index (DII) scores adults over 40 years old. Methods: Data were obtained from 2013 2018 National Health Nutrition Examination Survey (NHANES). present 9,929 participants included analyzed. The DII score was calculated divided into tertiles. Logistic regression analysis performed determine...
Objective: To explore the relationship between dietary inflammatory index (DII) and heart failure (HF) in participants with cardiovascular cerebrovascular diseases. Methods: NHANES (1998–2018) data were collected used to assess association of HF DII. Twenty-four-hour consumptions calculate scores Demographic characteristics physical laboratory examinations for comparison non-HF groups. Logistic regression analysis random forest performed odds rate determine potential beneficial components...
Tuberculosis (TB) remains a global health problem, and is the leading cause of death from an infectious disease. A crucial step in treatment tuberculosis screening high risk populations early detection disease, with chest x-ray (CXR) imaging being most widely-used modality. As such, there has been significant recent interest artificial intelligence-based TB solutions for use resource-limited scenarios where lack trained healthcare workers expertise CXR interpretation. Motivated by this...
The relationship between gut microbiota and its metabolites with cardiovascular disease (CVD) has been proven. In this review, we aim to conclude the potential mechanism of on inducing formation vulnerable atherosclerotic plaque, discuss effect intestinal metabolites, including trimethylamine-N-oxide (TMAO), lipopolysaccharide (LPS), phenylacetylglutamine (PAG), short-chain fatty acids (SCFAs) plaque stability. Finally, include impact stability, propose a new therapeutic direction for...
The changes in the microbial community structure during acute exacerbations of severe chronic obstructive pulmonary disease (COPD) hospitalized patients remain largely uncharacterized. Therefore, further studies focused on temporal dynamics and sputum communities exacerbation COPD (AECOPD) would still be necessary. In our study, use molecular microbiological techniques provided insight into both fungal bacterial diversities AECOPD hospitalization. particular, we examined varieties lung 6...
Metro drivers are more likely to trigger accidents if they suffer from cognitive distractions during manual driving. However, identifying metro drivers' faces challenges as generally no obvious behavior can be found the distractions. To address challenge, this paper identifies based on Electrocardiogram (ECG) signals collected by wearable devices in simulated driving experiments. The ECG processed generate ultra-short-term heart rate and variability (HR-HRV) features. HR-HRV features...
Ferulic acid, a main ingredient of Ligusticum, exhibits anti-oxidant and anti-inflammation effects in heart diseases. Some studies indicate that gut microbiome is associated with the generation ferulic acid. Whether beneficial effect raised by alteration microbiota still unknown. This study examined sodium ferulate on cardiac function TAC mice. Cell Counting Kit-8 (CCK8) assay verified acid has low toxicity vitro inhibited up-regulation β-MHC ANP induced Angiotensin II. In addition, daily...
Dysbiotic airway microbiota play important roles in the inflammatory progression of asthma, and exploration microbial interactions further elucidates asthma pathogenesis. However, little is known regarding bacterial-fungal patients. We conducted a cross-sectional survey sputum bacterial fungal from 116 clinically stable patients 29 healthy controls using 16S rRNA gene ITS1 sequencing. Compared with individuals, exhibited significantly altered increased alpha diversities airway. Microbial...
Antimicrobial resistance is a global concern in chronic respiratory diseases, including obstructive pulmonary disease (COPD). The collection of antibiotic genes or resistome human airways may underlie the resistance. COPD heterogeneous, and understanding airway relation to patient phenotype endotype inform precision therapy. Here, we characterized for 94 participants at stable disease. Among all demographic clinical factors, inflammatory was associated with resistome. There were distinct...