A5102004052- Migraine and Headache Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Trigeminal Neuralgia and Treatments
- Gastroesophageal reflux and treatments
- Head and Neck Surgical Oncology
- Pancreatic and Hepatic Oncology Research
- Sympathectomy and Hyperhidrosis Treatments
- Radiopharmaceutical Chemistry and Applications
- Head and Neck Cancer Studies
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Neurological disorders and treatments
- Peptidase Inhibition and Analysis
- Medical Imaging and Pathology Studies
- Epilepsy research and treatment
- Circadian rhythm and melatonin
- Neurological Disorders and Treatments
- Cancer and Skin Lesions
- Pancreatitis Pathology and Treatment
- Vascular Malformations and Hemangiomas
- Genetics, Aging, and Longevity in Model Organisms
- Infectious Diseases and Tuberculosis
- Ear and Head Tumors
- Immune Response and Inflammation
Nagoya University
2023-2025
Nihon University
2024
Shizuoka Cancer Center
2024
Tohoku Medical and Pharmaceutical University
2019-2023
Kyoto first Red Cross hospital
2002-2022
Tohoku Medical and Pharmaceutical University Hospital
2017-2022
Hirosaki University
2009-2019
Sendai City Hospital
2017
China Medical University
2009
Hiroshima University
2009
Mesial temporal lobe epilepsy (MTLE) is associated with disruptions in the temporo-amygdala-orbitofrontal (TAO) network, a key component of limbic system. We aimed to investigate TAO network alterations patients MTLE using magnetoencephalography (MEG), which overcomes susceptibility artifacts that limit functional MRI analysis orbitofrontal cortex. Nine seizure-free post-temporal lobectomy and nine age- sex-matched healthy controls were recruited. Preoperative MEG data collected segmented...
Background/Objectives: Lasmiditan is a newly developed drug for the acute treatment of migraine attacks, but factors associated with its efficacy remain unclear. This study aimed to confirm lasmiditan started at 50 mg under various dosing conditions and identify efficacy. Methods: There were four reasons prescribing lasmiditan: add-on triptan, ineffectiveness side effects triptan contraindicated. was dose mg. Efficacy defined as disappearance headache or 50% greater reduction in intensity...
PERIOD1 (PER1) is a clock gene. We examined the effect of knockdown PER1 on apoptosis in pancreatic cancer (MIA PaCa-2 and PANC-1) hepatocellular carcinoma (HepG2) cells. Transfection siRNA against into these cells increased cleaved forms caspases poly-ADP-ribose-polymerase induced all three cell lines. In two lines, resulted upregulation Bax downregulation Bcl-2. Expression p53 was not altered lines containing mutated p53, but upregulated HepG2 wild-type p53. Cell proliferation MIA...
AIM:To investigate the efficacy of rebamipide in a rat model colitis and restitution intestinal epithelial cells vitro . METHODS:Acute was induced with trinitro-benzene sulfonic acid (TNBS) male Wistar rats.Rats received intrarectal treatment daily starting on day 7 were sacrificed 14 after TNBS administration.The distal colon removed to evaluate various parameters inflammation.Moreover, wound healing assays used determine enhanced (RIE) treated rebamipide. RESULTS:Intracolonic...
Recent studies have found alterations to clock genes in several forms of cancer. Period (Per) gene plays an important role the circadian system, cell cycle, induction apoptosis, and DNA damage. However, functions Per pancreatic cancer not yet been elucidated. Here, we show that tumor necrosis factor-α (TNF-α) suppressed expression both Per1 Per3 MIA-PaCa2 cells, a human line. The levels these proteins were 10% lower cells treated with 10 ng/mL TNF-α. Cell proliferation showed 15%, 14%, 16%...
Biliary tract cancer (cancer of gallbladder and extrahepatic bile duct) is the most common malignancy biliary tract, considered to be a high-grade malignancy. In this study, we reviewed 293 cancers 102 duct for clarifying growth invasion cancer. Only 10.5% (9/86) early showed lymphatic invasion, but neither venous nor lymph node metastasis was noted in cancers. 70.6% (207/293) cases were pT2-3 cancers, frequently lymphatic/venous/perineural and/or metastasis. 12.7% (13/102) pTis or pT1 which...
Commercial aviation maintenance related incidents reported to the Aviation Safety Report System were investigated focusing on coordination problems. Among 1000 analyzed reports from a two-year period, 98 internal issues within team, and 24 external between other departments discovered. Frequently established problematic included: not delivering information, sending wrong information lack of responsibility. Most conflicts solved by competing (or accommodating) behavior, such that one party...
Objective Post–endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis involves persistent serum amylase levels of 3 times or more the standard upper limit. However, these criteria were mostly based on retrospective studies and not necessarily supported by diagnostic imaging. Our prospective study aimed to investigate cutoff suggesting post-ERCP using computed tomography as criterion standard. Methods We prospectively followed 2078 cases. Computed was performed in patients whose...
Abstract Background Abrupt discontinuation of overused medications is the gold standard treatment for medication overuse headache (MOH), but difficult to maintain. In this study, aim was evaluate real-world clinical results anti-calcitonin gene-related peptide monoclonal antibody (CGRP-mAb) MOH migraine without abrupt drug and no hospitalization. Methods Patients with receiving naïve CGRP-mAb were enrolled. Data collected before starting injections (baseline) after each injection. The...
In the treatment of non-small cell lung cancer (NSCLC), a disease-free survival (DFS) 5 years is criterion for cure. This study aimed to evaluate characteristics and outcomes patients with brain metastases NSCLC after DFS (late recurrent metastasis, LRBM). We reviewed 1,281 consecutive metastasis at single institute between November 2014 December 2022. Relevant articles were retrieved from PubMed. Only peer-reviewed journals published in English included. Six (0.47%) showed LRBM. Three male....
Background: Abrupt discontinuation of overused medications is standard treatment for medication overuse headache (MOH), but difficult to maintain. The aim was evaluate the real-world clinical results anti-calcitonin gene-related peptide monoclonal antibody (CGRP-mAb) MOH migraine without abrupt drug and no hospitalization. Methods: Data were collected before starting CGRP-mAb injections (baseline) after each injection. following items compared between baseline injection: monthly days (MHD),...
Abstract Metaplastic breast carcinoma (MBC), a category of cancer, includes different histological types, which are occasionally mixed and heterogeneous. Considering the heterogeneity cancer cells in tumour mass has become highly significant, not only from biological aspect but also for clinical management recurrence. This study aimed to analyse immunohistochemical molecular profiles each MBC component mass. Twenty-five tumours were histologically evaluated, most frequent (c) was squamous...
Abrupt discontinuation of overused medications is standard treatment for medication overuse headache (MOH), but difficult to maintain. The aim was evaluate the real-world clinical results anti-calcitonin gene-related peptide monoclonal antibody (CGRP-mAb) migraine with MOH without abrupt drug and no hospitalization.
The aim of this study was to identify the incidence and risk factors for post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) after emergency endoscopic (ERCP).We performed a prospective multicenter observational 3914 patients who underwent ERCP. We compared PEP elective ERCP.A total 3410 were enrolled in study. Post-ERCP occurred 44 800 (5.5%) 190 2418 (7.9%) groups, respectively. No significant difference noted between groups (odds ratio [OR], 0.73; 95% confidence...
Radon is the second most important risk factor for lung cancer after tobacco smoking. In Chiang Mai, Thailand, values of indoor radon activity concentrations are considerably higher than global average and it a highest level among East Asian countries. The aim our study to identify novel biomarkers in high areas using proteomic approach. transitional study, total 81 participants non-smokers were examined, consist 25 patients (LC), 16 healthy controls from low levels natural radiation (LLNRA)...
A 79-year-old Japanese woman presented with a rare case of metastatic renal cell carcinoma to the left sphenoid sinus nasal bleeding. She had previously right radical nephrectomy for at age 64 years and brain spinal cord infarction 74 years. Endoscopic examination revealed no mass in cavity. CT MRI tumor sinus. The size increased gradually from 12 15 after nephrectomy. Complete resection endoscopic surgery was performed without preoperative embolization. cells clear cytoplasm were arranged...