A5018386287- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- RNA regulation and disease
- Cancer-related molecular mechanisms research
- Viral Infections and Immunology Research
- Advanced Database Systems and Queries
- Protein Structure and Dynamics
- PI3K/AKT/mTOR signaling in cancer
- Fluid Dynamics and Turbulent Flows
- Turbomachinery Performance and Optimization
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Chromatin Remodeling and Cancer
- Advanced Adaptive Filtering Techniques
- Data Management and Algorithms
- Histiocytic Disorders and Treatments
- Computational Drug Discovery Methods
- vaccines and immunoinformatics approaches
- Speech Recognition and Synthesis
- Cancer Research and Treatments
- biodegradable polymer synthesis and properties
- Speech and Audio Processing
- Endoplasmic Reticulum Stress and Disease
- Heat Transfer Mechanisms
Tsinghua University
2019-2023
Guizhou Center for Disease Control and Prevention
2023
Zunyi Medical University
2023
National Institute of Biological Sciences, Beijing
2019-2022
Peking University
2022
Lanzhou Jiaotong University
2022
Tianjin Medical University
2018
Xi'an Jiaotong University
2013
Beijing University of Technology
2013
Abstract Cells mitigate ER stress through the unfolded protein response (UPR). Here, we report formation of whorls as an effector mechanism response. We found that strong induces whorls, which contain ER-resident proteins such Sec61 complex and PKR-like kinase (PERK). whorl is dependent on PERK activity mediated by COPII machinery, facilitates membrane budding to form tubular-vesicular precursors. precursors then go Sec22b-mediated fusion whorls. further show contribute stress-induced...
Abstract A major part of the transcriptome complexity is attributed to multiple types DNA or RNA fusion events, which take place within a gene such as alternative splicing between different genes rearrangement and trans-splicing. In present study, using deep sequencing data, we systematically survey type non-canonical fusions transcripts from two opposite strands. We name products events cross-strand chimeric (cscRNA). Hundreds thousands cscRNAs can be found in human normal tissues, primary...
Abstract The quickly accumulating ribosome profiling data is an insightful resource for studying the critical details of translation regulation under various biological contexts. Rocaglamide A (RocA), antitumor heterotricyclic natural compound, has been shown to inhibit initiation a large group mRNA species by clamping eIF4A onto poly-purine motifs in 5′ UTRs. However, reanalysis previous datasets reveals unexpected shift occupancy pattern, upon RocA treatment types cells, during early...
Ribosome profiling has been widely used for studies of translation under a large variety cellular and physiological contexts. Many these have greatly benefitted from series data-mining tools designed dissection the translatome different aspects. However, as advance quickly, current toolbox still falls in short, more specialized are urgent need deeper efficient mining important new features landscapes.Here, we present RiboMiner, bioinformatics toolset multi-dimensional with ribosome data....
EV71, a significant pathogen causing hand-foot-mouth disease, is associated with severe neurological complications such as brain stem encephalitis, aseptic meningitis, and acute flaccid paralysis. While the role of mitochondrial dynamics in regulating replication numerous viruses recognized, its specific involvement EV71 remains unclear. This study aimed to elucidate human neuroblastoma SK-N-SH cells during infection. Utilizing laser confocal microscopy transmission electron microscopy, we...
Abstract The metabolic enzyme isocitrate dehydrogenase 1 (IDH1) catalyzes the oxidative decarboxylation of to α-ketoglutarate (α-KG). Its mutation often leads aberrant gene expression in cancer. IDH1 was reported bind thousands RNA transcripts a sequence-dependent manner; yet, functional significance this RNA-binding activity remains elusive. Here, we report that promotes mRNA translation via direct associations with polysome and machinery. Comprehensive proteomic analysis embryonic stem...
SNF5, is a core member of the SWI/SNF chromatin remodeling complex. It's deficiency leads to multiple types aggressive cancer. Sézary syndrome, leukemic variant cutaneous T-cell lymphoma, characterized by its resistance apoptosis. Although cause apoptosis still poorly understood, recent evidence has revealed importance SATB1 in syndrome. In this study, we show that SNF5 an upstream regulator several conditions and both are deficient cells. Additionally, not only controls expression SATB1,...
Summary eIF3 is a multi-subunit complex with numerous functions in canonical translation initiation. was also found to interact 40S and 60S ribosomal proteins elongation factors, but direct involvement has never been demonstrated. We that deficiency reduced early speed between codons 25 75 on set of ∼2,700 mRNAs encoding associated mitochondrial membrane functions, resulting defective synthesis their encoded proteins. To promote elongation, interacts 80S ribosomes translating the first ∼60...
Identification of open reading frames (ORFs), especially those encoding small peptides and being actively translated under specific physiological contexts, is critical for comprehensive annotations context-dependent translatomes. Ribosome profiling, a technique detecting the binding locations densities translating ribosomes on RNA, offers an avenue to rapidly discover where translation occurring at genome-wide scale. However, it not trivial task in bioinformatics efficiently comprehensively...
Identification of open reading frames (ORFs), especially those encoding small peptides and being actively translated under specific physiological contexts, is critical for comprehensive annotations context-dependent translatomes. Ribosome profiling, a technique detecting the binding locations densities translating ribosomes on RNA, offers an avenue to rapidly discover where translation occurring at genome-wide scale. However, it not trivial task in bioinformatics efficiently comprehensively...
Twig pattern matching is core operation in XML query processing. Although holistic twig algorithms have been studied intensively nowadays, little attention paid on positional predicates defined navigation axis. These cannot be used to implement XPath queries with predicates, since the results fail selected from results. For implementation of this paper extends traditional a new one called ExTwig deal both and following sibling The corresponding algorithm TwigPos also proposed process query....
EV71, a significant pathogen causing hand-foot-mouth disease, is associated with severe neurological complications such as brain stem encephalitis, aseptic meningitis, and acute flaccid paralysis. While the role of mitochondrial dynamics in regulating replication numerous viruses recognized, its specific involvement EV71 remains unclear. This study aimed to elucidate human neuroblastoma SK-N-SH cells during infection. Utilizing laser confocal microscopy transmission electron microscopy, we...
The spectrogram of speech has characteristics such as time dependence and local correlation, classical neural network models cannot be fully adapted to the time-frequency speech. Convolutional recurrent (CRN) can not only capture patterns spectrogram, but also model dependencies between consecutive frames. In this paper, we introduce gated linear unit (GLU) into convolutional encoder-decoder (CED) structure CRN design a (GCRN) for real-time monaural enhancement. We replace long short-term...