A5037215501- Contact Dermatitis and Allergies
- Occupational exposure and asthma
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Pesticide Exposure and Toxicity
- Food Allergy and Anaphylaxis Research
- Drug-Induced Adverse Reactions
- Nail Diseases and Treatments
- Skin Protection and Aging
- Immunotoxicology and immune responses
- Herpesvirus Infections and Treatments
- Advancements in Transdermal Drug Delivery
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Virus-based gene therapy research
- Tattoo and Body Piercing Complications
- Medical Practices and Rehabilitation
- Asthma and respiratory diseases
- Body Image and Dysmorphia Studies
- Animal testing and alternatives
- Indoor Air Quality and Microbial Exposure
- Poxvirus research and outbreaks
- Cutaneous Melanoma Detection and Management
- Immunotherapy and Immune Responses
- Agricultural safety and regulations
- Delphi Technique in Research
Osnabrück University
2016-2025
Hospital Marina Baixa
2024
Klinikum Osnabrück
2023
BG Klinikum Hamburg
2023
Liechtenstein Institute
2023
Oxfam
2023
Magnus Bergvalls Stiftelse
2021-2023
John Wiley & Sons (United States)
2021
Mahle (Germany)
2021
Advanced Dermatology
2021
Hand eczema is a common inflammatory skin disorder. Health care providers need continuously updated information about the management of hand to ensure best treatment for their patients.To update European Society Contact Dermatitis guideline on diagnosis, prevention, and eczema.The Guideline Development Group (GDG) was established behalf ESCD. A call interest launched via ESCD website members' mailing list. Appraisal evidence therapeutic preventive interventions applied structured method...
Summary Background A tertiary individual prevention programme ( TIP ) is offered to patients with severe occupational skin disease OSD in Germany. Previously, it was shown that the burden of s considerably reduced up 1 year after . Objectives To evaluate long‐term effects Patients and methods In a prospective multicentre cohort study, clinical patient‐reported outcome data 3 years were evaluated. Results Of 1788 initially included 1410 available for 3‐year follow‐up analysis. The severity ,...
Objective: The aim of this study was to explore the tape strip sampling technique in assessment stratum corneum levels inflammatory mediators a clinical trial setting. Methods: Thirty-eight were analyzed by multiplex-assay corneum, collected adhesive tapes before and after 6 weeks therapy, mild moderate atopic dermatitis (AD) patients (n = 90). Treatment ceramide- magnesium-containing emollient. Results: Twenty-four could quantitatively be determined. Th2 interleukin (IL)-4, IL-13, CCL2...
Continual analyses of patch test results with the European baseline series (EBS) serve both contact allergy surveillance and auditing value included allergens.To present current EBS testing, obtained in 53 departments 13 countries during 2019 2020.Anonymised or pseudonymised individual data partly aggregated on demographic/clinical characteristics rest were prospectively collected centrally pooled analysed.In 2020, 22 581 patients tested EBS. Sensitization to nickel remained most common...
Occupational skin diseases have led the occupational disease statistics in Europe for many years. Especially allergic contact dermatitis is associated with a poor prognosis and low healing rates leading to an enormous burden affected individual society.To present sensitization frequencies most relevant allergens of European baseline series patients (OCD) compare profiles different occupations.The data 16 022 considered having OCD after patch testing within Surveillance System on Contact...
Clinical surveillance of the prevalence contact allergy in consecutively patch tested patients is a proven instrument to continually assess importance allergens (haptens) assembled baseline series.To present current results from European Surveillance System on Contact Allergies, including 13 countries represented by 1 11 departments.Anonymized or pseudonymized test and clinical data various capture systems used locally nationally as transferred Erlangen centre were pooled descriptively...
Abstract Background Methylisothiazolinone (MI) has caused an unprecedented epidemic of contact allergy in Europe and elsewhere. Subsequently, regulatory action been taken, at least Europe, aiming reducing risk MI sensitization. Objective To follow‐up on the prevalence to consecutively patch tested patients assess spectrum products containing or methylchloroisothiazolinone (MCI)/MI positive which elicited current allergic dermatitis. Methods A cross‐sectional survey was performed 2016 2017,...
Filaggrin loss-of-function mutations and atopy may alter the clinical course of irritant contact dermatitis (ICD).To investigate patients with occupational ICD according to in filaggrin gene (FLG) atopy.In a prospective cohort study, course, use topical corticosteroids, sick leave, recovery rate job continuation were investigated 459 inpatients treated for hands. Patients genotyped four FLG mutations, examined followed up 3 years after discharge.Our study included 327 (71·2%) atopic...
Summary Background Interleukin (IL)-31 is a novel Th2 T-cell cytokine that induces pruritus and dermatitis in transgenic mice. While enhanced mRNA expression of this detected skin samples inflammatory diseases, the regulation IL-31 poorly understood. Objectives To assess effects ultraviolet (UV) B radiation H2O2 on protein different peripheral blood mononuclear cells (PBMCs). Methods The UVB H2O2, as prototypic reactive oxygen species, were analysed various inflammation-related murine...
Journal Article Association between tobacco smoking and prognosis of occupational hand eczema: a prospective cohort study Get access R. Brans, Brans Department Dermatology, Environmental Medicine, Health Theory University Osnabrück 49090 GermanyInstitute for Interdisciplinary Dermatologic Prevention Rehabilitation (iDerm) at the Centre Trauma Hospital 21033 Hamburg Germany Correspondence Richard Brans. E‐mail: rbrans@uos.de Search other works by this author on: Oxford Academic Google Scholar...
Foot eczema often occurs in combination with hand eczema. However, contrast to the situation eczema, knowledge about foot is scarce, especially occupational settings.To evaluate prevalence of and associated factors patients taking part a tertiary individual prevention programme for skin diseases.In retrospective cohort study, medical records 843 were evaluated.Seven hundred twenty-three (85.8%) suffered from Among these, 201 (27.8%) had concomitant mainly atopic (60.4%). An irritant...
Skin cancer is the most common malignancy in Caucasian populations worldwide and ultraviolet radiation (UVR) known for being number one carcinogen. As, especially outdoor workers, UVR an inevitable carcinogen, prevention management of UVR-related skin cancers these at-risk represent a collective challenge dermatologists healthcare policymakers likewise.To provide overview on current regulations acknowledgement work-related 11 European countries.Dermatologists from countries networking within...
Benzisothiazolinone (BIT; CAS no. 2634-33-5) is used as a biocide in various products, including water-based paints, metalworking fluids, and household products. In recent years, increasing sensitization rates have been observed Europe.To describe time trend of to BIT, analyse concomitant reactions, identify patients with increased risk BIT sensitization.Retrospective analysis data from 26 739 patch tested sodium salt, 0.1% petrolatum part several special test series within the Information...
Abstract Background The use of methylisothiazolinone (MI) as a preservative in cosmetic products caused an alarming increase MI contact allergy across Europe the 2010s. This was followed by regulations with total ban on leave‐on (implemented 2017) and reduced concentrations rinse‐off cosmetics (2018). Objective To follow‐up prevalence to related benzisothiazolinone (BIT) octylisothiazolinone (OIT) consecutively patch‐tested patients Europe. Methods A cross‐sectional audit following design...
Allergic contact dermatitis (ACD) is one of the most common occupational skin diseases (OSDs). Its prevalence and causative allergens differ between occupations.To evaluate ACD pattern patch test results patients taking part in a tertiary individual prevention programme (TIP) for OSD Germany.In retrospective cohort study, data 3411 TIP tested 2007 2016 were analysed.In 2687 (78.8%) patients, work-related disease was diagnosed, mostly hand dermatitis. The highest proportion face seen painters...
A two-fold risk increase to develop basal cell carcinoma was seen in outdoor workers exposed high solar UV radiation compared controls. However, there is an ongoing discussion whether histopathological subtype, tumor localization and Fitzpatrick phototype may influence the estimates.To evaluate of histological on highly UV-exposed cases controls those with moderate or low exposure.Six hundred forty-three participants suffering from incident commonly sun-exposed anatomic sites (capillitium,...
Allergic contact dermatitis is one of the most frequent occupational skin diseases. Targeted allergen avoidance can only be achieved by identification causative allergen. Therefore, patch testing utmost importance in dermatology, not terms assessing causal relationships but also regarding implementation prevention measures and evaluation legal criteria for an disease Germany (statutory BK 5101). The lack commercial test preparations poses a great diagnostic challenge. Patch patient's own...
The objective of this study was to compare optical coherence tomography (OCT) with conventional techniques such as KOH-preparation, culture and histology in the identification fungal elements nail. A total 18 patients were examined; 10 clinically evident onychomycosis toe nails, two psoriatic nail lesions, one affection caused by lichen planus five healthy controls. Serial vivo OCT analyses performed prior punch biopsy plate for consecutive histology. Fungal detected non-invasively using all...