A5071381729- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cancer Cells and Metastasis
- Uterine Myomas and Treatments
- HER2/EGFR in Cancer Research
- Cancer and Skin Lesions
- Cancer Immunotherapy and Biomarkers
- Breast Implant and Reconstruction
- Endometriosis Research and Treatment
- Sarcoma Diagnosis and Treatment
- Reproductive System and Pregnancy
- Vascular Tumors and Angiosarcomas
- Lymphoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Advanced Breast Cancer Therapies
- Cervical Cancer and HPV Research
- Gynecological conditions and treatments
- Congenital Diaphragmatic Hernia Studies
- Metastasis and carcinoma case studies
- Esophageal Cancer Research and Treatment
- MRI in cancer diagnosis
- Cancer Genomics and Diagnostics
- Urologic and reproductive health conditions
Istanbul University
2015-2025
Henry Ford Health System
1999
Metaplastic breast carcinoma (MBC) differs from classic invasive ductal carcinomas regarding incidence, pathogenesis, and prognosis. The purpose of this study was to compare patients with MBC clinicopathologic treatment-matched triple-negative (TNBC) in terms response treatment, progression, survival. Fifty-four 51 TNBC, who were treated at Istanbul University, Institute Oncology, between 1993 2014, included the study. After correctly matching 1 2 groups, they compared determine differences...
DNA methylation of polycomb group target (PCGT) genes is an early step in carcinogenesis and could potentially be assayed to determine cancer risk prediction. To assess whether changes PCGT normal tissue able predict the presence cancer, we studied HOXA gene endometrium from premenopausal ovarian patients age-matched healthy controls without cancer. HOXA9 HOXA11 was associated with initial test set this subsequently confirmed independent validation sample sets. The overall increased...
The aim of this study was to evaluate the diagnostic value 2-(fluorine-18)-fluoro-2-deoxy-D-glucose ((18)F-FDG) PET/CT in comparison with MRI for detection recurrent ovarian cancer.Forty-seven patients suspected cancer recurrence after total ablative or cytoreductive surgery, as well neoadjuvant adjuvant chemotherapy, who had undergone (18)F-FDG imaging were recruited present study. All also underwent within a month same purpose. Recurrent abdomen and pelvis evaluated each 47 classified...
Background: Whether sentinel lymph node biopsy (SLNB) should be performed in patients with pure ductal carcinoma situ (DCIS) of the breast has been a question debate over last decade. The aim this study was to identify factors associated microinvasive disease and determine criteria for performing SLNB DCIS. Materials Methods: 125 DCIS who underwent surgery between January 2000 December 2008 were reviewed microinvasion (DCISM). Results: 88 (70.4%) had 37 (29.6%) DCISM. Among 33 SLNB, one...
The purpose of this study was to evaluate ultrasound-guided surgery for palpable breast cancer by comparing the standard palpation-guided in terms extent healthy tissue resection, percentage tumor-free margins, and cosmetic outcomes. This a prospective, observational cohort conducted from January 2009 July 2011. Breast patients, diagnosed via biopsy, were operated guidance with either ultrasound or palpation. Patient demographics, tumor features, intraoperative findings, pathologic results,...
Studies on PD-L1 expression in breast cancer have gained importance recent years, especially triple-negative (TNBC). Our aim was to analyze the differential of explore its correlation with response neoadjuvant chemotherapy (NACT) and patient survival.PD-L1 evaluated immunohistochemically (Ventana SP263 clone kit) by staining tumor specimen. positivity defined as membranous > 1%, 5%, 10%, 20% either cell (TC) /or immune (IC).Fifty patients locally advanced TNBC, who had a partial NACT, were...
Abstract Purpose This study aimed to determine estrogen receptor (ER) expression in stromal cells postchemotherapy tumor bed (PCTB) and its relationship with regression characteristics. Methods The included 490 breast cancer patients who received neoadjuvant chemotherapy (NAC). We performed ER all resection specimens available pre-treatment core biopsy materials of 299 immunohistochemically. Results Two hundred forty-two (49.4%) cases were negative for the PCTB, 248 (50.6%) positive....
The research aims to understand the views of preschool teachers working in Bahcelievler district Istanbul, affiliated with Ministry National Education (MoNE), regarding strengths and areas for improvement 2024 MoNE Preschool Program Türkiye Century Model (2024) (1). This study employs a qualitative method, specifically case design, characterized as holistic single study. convenience sampling type purposeful commonly used research, has been utilized sample selection. A total 15 voluntarily...
This study was conducted to determine the demographic and clinicopathologic characteristics evaluate prognostic value of various factors, such as extensiveness surgery, related tumour itself clinical features in recurrence borderline ovarian tumours (BOT). We retrospectively evaluated data 103 patients with a treated at our institution between years 2000 2012. The median age 37 (16–79) majority were premenopausal (76.7%). During follow-up, 16 recurrences observed (15.5%). multivariate...
Abstract Background The expression of immune checkpoint receptors (ICRs) on tumor-infiltrating lymphocytes (TILs) is associated with better response to immunotherapies via inhibitors. Therefore, we investigated various ICR expressions TILs in patients locally advanced triple-negative breast cancer (TNBC) after neoadjuvant chemotherapy (NAC). Methods Expressions ICRs were examined immunohistochemically surgical specimens ( n = 61) using monoclonal antibodies for PDL-1, PD-1, TIM-3, LAG-3, and...
ABSTRACT Introduction Achieving a pCR serves as biomarker indicating enhanced overall survival for breast cancer patients undergoing NST. Vitamin D enhances the antitumor effect of chemotherapeutics demonstrated in cells and animal models. In this prospective randomized clinical study, we aim to investigate oral vitamin supplementation during neoadjuvant systemic therapy (NST) on pathologic complete response (pCR). Methods Between June 2019 2023, an form 50,000 IU D3 (cholecalciferol)...
Background: There are still ongoing controversies about several aspects of lymphatic mapping and sentinel lymph node biopsy for breast cancer, including injection site radioisotope blue dye. This study aims to evaluate the success rate different radiocolloid techniques in detection nodes (SLN) early cancer. Study Design: One hundred ninety-two women with cancer were included. For SLN lymphoscintigraphy (LSG), 5 injections used. Group A (36 patients) had 4 peritumoral (PT), group B (n = 36) 1...
Undifferentiated/dedifferentiated endometrial carcinomas (UCE/DCEs) of the endometrium are rare tumors with poor prognosis. There few clinicopathologic studies detailed immunohistochemical analysis regarding UCE/DCEs. We evaluated diagnostic value a selected tumor stem-cell marker and epithelial-mesenchymal transition (EMT) markers, in addition to previously studied markers identifying UCE/DCEs from other types high-grade carcinomas. Eleven cases complete clinical follow-up that were...
Background Many publications have examined the relationship between apparent diffusion coefficient (ADC) values and tumor grade in endometrial cancer. Nevertheless, none were designed to evaluate according histopathological type of endometrioid non-endometrioid tumors. Purpose To role diffusion-weighted imaging (DWI) differential diagnosis cancer uterus, by comparing them with contrast-enhanced magnetic resonance (MRI) findings. Material Methods Institutional review board approval informed...