A5015784929- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Immune Cell Function and Interaction
- Psoriasis: Treatment and Pathogenesis
- Cancer Cells and Metastasis
- Whipple's Disease and Interleukins
- Genomics and Rare Diseases
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Genetic Associations and Epidemiology
- T-cell and B-cell Immunology
- Digestive system and related health
- Peptidase Inhibition and Analysis
- TGF-β signaling in diseases
- Genetic factors in colorectal cancer
- Lymphatic System and Diseases
- Epigenetics and DNA Methylation
- Molecular Biology Techniques and Applications
- Angiogenesis and VEGF in Cancer
- Telomeres, Telomerase, and Senescence
- Pediatric health and respiratory diseases
- Influenza Virus Research Studies
- Cancer Genomics and Diagnostics
- Respiratory viral infections research
- interferon and immune responses
AstraZeneca (United Kingdom)
2020-2025
AstraZeneca (Sweden)
2024
Amsterdam University Medical Centers
2018-2019
University of Amsterdam
2017-2019
Amsterdam UMC Location University of Amsterdam
2016-2018
Integrating human genomics and proteomics can help elucidate disease mechanisms, identify clinical biomarkers discover drug targets1-4. Because previous proteogenomic studies have focused on common variation via genome-wide association studies, the contribution of rare variants to plasma proteome remains largely unknown. Here we associations between protein-coding 2,923 protein abundances measured in 49,736 UK Biobank individuals. Our variant-level exome-wide study identified 5,433...
Abstract Innate lymphoid cells (ILCs) are crucial for the immune surveillance at mucosal sites. ILCs coordinate early eradication of pathogens and contribute to tissue healing remodeling, features that dysfunctional in patients with cystic fibrosis (CF). The mechanisms by which CF-immunopathology ill-defined. Here, we show group 2 (ILC2s) transdifferentiated into IL-17-secreting presence epithelial-derived cytokines IL-1β, IL-23 TGF-β. This conversion is abrogated IL-4 or vitamin D3. IL-17...
Highlights•NRP1+ ILC3s are present in lymphoid tissues, but not the peripheral blood or skin•NRP1+ express CD45RO and produce higher amounts of cytokines than NRP1− ILC3s•NRP1 is a marker for human with LTi phenotype vitro activity•NRP1+ lung tissues from smokers COPD patientsSummaryHere, we characterize subset that Neuropilin1 (NRP1) skin. NRP1+ group 3 innate cells (ILC3s) display tissue inducer (LTi) activity. In agreement this, mainly located proximity to high endothelial venules (HEVs)...
Background Epithelial damage, repair and remodelling are critical features of chronic airway diseases including obstructive pulmonary disease (COPD). Interleukin (IL)-33 released from damaged epithelia causes inflammation via its receptor, serum stimulation-2 (ST2). Oxidation IL-33 to a non-ST2-binding form (IL-33 ox ) is thought limit activity. We investigated whether has functional activities that independent ST2 in the epithelium. Methods In vitro epithelial damage assays...
Abstract Compared to intramuscular vaccines, nasally administered vaccines have the advantage of inducing local mucosal immune responses that may block infection and interrupt transmission respiratory pathogens. Live attenuated influenza vaccine (LAIV) is effective in preventing children, but a correlate protection for LAIV remains unclear. Studying young adult volunteers, we observe induces distinct, compartmentalized, antibody mucosa blood. Seeking immunologic correlates these distinct...
Telomeres protect chromosome ends from damage and their length is linked with human disease aging. We developed a joint telomere metric, combining quantitative PCR whole-genome sequencing measurements 462,666 UK Biobank participants. This metric increased SNP heritability, suggesting that it better captures genetic regulation of length. Exome-wide rare-variant gene-level collapsing association studies identified 64 variants 30 genes significantly associated length, including allelic series...
Group 3 innate lymphoid cells (ILC3) are potent effector with critical roles in enforcing immunity, barrier integrity and tissue homeostasis along the gastrointestinal tract. ILC3 considered primarily tissue-resident cells, seeding tract during embryonic stages early life. However, mechanisms through which mature maintained within adult tissues poorly understood. Here, we report that tissue-inducer-like (LTi-like) exhibit minimal turnover healthy intestinal tract, persist for extended...
Abstract Group 3 innate lymphoid cells (ILC3) are potent effector with critical roles in enforcing immunity, barrier integrity and tissue homeostasis along the gastrointestinal tract. ILC3 considered to be primarily tissue-resident cells, seeding tract during embryonic stages. However, mechanisms through which maintained within these tissues poorly understood. Here, we report that minimally replenished from bone marrow precursors healthy adult mice, persist for extended periods of time gut,...
The cytokine, interleukin-33 (IL-33), has emerged as a promising therapeutic target in chronic respiratory diseases and viral exacerbations. Despite great progress being made with simple cell assays, aspects of IL-33 biology require further investigation complex, translational systems. Consequently, the aim this work was to develop human precision-cut lung slice (huPCLS) platform suitable explore test novel therapies. huPCLS were generated cultured for up 7 days. LDH levels H&E staining...