A5049465547- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Thyroid Cancer Diagnosis and Treatment
- Inflammatory Bowel Disease
- Ovarian function and disorders
- Vascular Malformations Diagnosis and Treatment
- Genomics and Rare Diseases
- Gastric Cancer Management and Outcomes
- Hypothalamic control of reproductive hormones
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Eosinophilic Esophagitis
- Colorectal Cancer Screening and Detection
- Estrogen and related hormone effects
- Reproductive Biology and Fertility
- DNA Repair Mechanisms
- Bacterial Genetics and Biotechnology
- CRISPR and Genetic Engineering
- Microscopic Colitis
- Sperm and Testicular Function
- Extracellular vesicles in disease
- Growth Hormone and Insulin-like Growth Factors
- Sexual Differentiation and Disorders
- Celiac Disease Research and Management
- Advanced Breast Cancer Therapies
Azienda Unità Sanitaria Locale di Ferrara
2024-2025
Riverside University Health System - Medical Center
2025
Ospedale Santa Maria della Misericordia di Udine
2005-2025
Istituto Oncologico Veneto
2024
University of Padua
2024
University of Modena and Reggio Emilia
2013-2023
University of Turin
2010-2022
Novartis (Italy)
2021
University of Udine
2015-2019
Azienda Unita' Sanitaria Locale Di Modena
2013-2017
ABSTRACT Bacillus subtilis grows in the absence of oxygen using nitrate ammonification and various fermentation processes. Lactate, acetate, 2,3-butanediol were identified growth medium as major anaerobic products by high-performance liquid chromatography. Lactate formation was found to be dependent on lctEP locus, encoding lactate dehydrogenase a putative permease. Mutation lctE results drastically reduced independent presence alternative electron acceptors, indicating importance NADH...
Does the sperm DNA fragmentation index (DFI) improve depending on FSH receptor (FSHR) genotype as assessed by nonsynonymous polymorphisms rs6166 (p.N680S) after 3 months of recombinant treatment in men with idiopathic infertility? significantly improves DFI only infertile p.N680S homozygous N FSHR. FSH, fundamental for spermatogenesis, is empirically used to treat male infertility and several studies suggest that could be a candidate predictor response treatment, terms probability conceive....
Human luteinizing hormone (LH) and chorionic gonadotropin (hCG) are glycoprotein hormones regulating development reproductive functions by acting on the same receptor (LHCGR). We compared LH hCG activity in gonadal cells from male mouse vitro, i.e. primary Leydig cells, which is a common tool used for bioassay. Murine naturally expressing murine (mLhr), binds human LH/hCG.Cultured were treated increasing doses of recombinant hCG, cell signaling, gene expression steroid synthesis evaluated.We...
Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are glycoprotein hormones used for assisted reproduction acting on the same receptor (LHCGR) mediating different intracellular signaling. We evaluated pro- anti-apoptotic effect of 100 pM LH or hCG, in presence absence 200 pg/mL 17β-estradiol, long-term, serum-starved primary granulosa cells (hGLC) a transfected cell line overexpressing LHCGR (hGL5/LHCGR). To this purpose, phospho-extracellular-regulated kinase 1/2 (pERK1/2),...
The rapid evolution of Next Generation Sequencing in clinical settings, and the resulting challenge variant reinterpretation given constantly updated information, require robust data management systems organized approaches. In this paper, we present iVar: a freely available highly customizable tool with user-friendly web interface. It represents platform for unified variants identified by different sequencing technologies. iVar accepts call format (VCF) files text annotation elaborates them,...
ABSTRACT During anaerobic nitrate respiration Bacillus subtilis reduces via nitrite to ammonia. No denitrification products were observed. B. wild-type cells and a reductase mutant grew anaerobically with as an electron acceptor. Oxygen-sensitive dissimilatory activity was demonstrated in cell extracts prepared from both strains benzyl viologen donor The expression of the discovered dependent on regulatory system encoded by resDE . Mutation gene encoding Fnr had no negative effect formation.
Abstract Background In the current healthcare economy, implementation of telemedicine is rapidly evolving.The rationale for development and advancement in this area seems to be dual: first, improve speed efficiency supply health counseling decision making, second, provide access patients rural areas.IBD has a significant medical, social financial impact considering constant increasing worldwide its incidence prevalence.Our study aims determine how much "Help-line telephone" form that...
Journal Article Recurrence patterns and post-recurrence survival of patients with bilobar colorectal liver metastases: international multicentre retrospective study Get access Bilobar CRC Liver Metastases Research Collaborative Search for other works by this author on: Oxford Academic Google Scholar British Surgery, Volume 112, Issue 3, March 2025, znaf003, https://doi.org/10.1093/bjs/znaf003 Published: 04 2025 history Received: 19 2024 Revision received: 24 September Accepted: 03 January
3156 Background: Fasting-mimicking diets (FMD) can induce favorable immune-metabolic changes in humans and preclinical data suggest potential antitumor activity. Cyclic FMD impact on muscle mass adiposity patients (pts) is unclear. Here we evaluate body composition pts with advanced solid cancers undergoing the context of a phase Ib trial (NCT03340935). Methods: NCT03340935 study evaluated safety biological effects cyclic consisting 5-day, calorie-restricted, plant-based diet repeated every...
In patients with postoperative recurrence of Crohn's disease endoscopic and clinical remission can be maintained for up to 1 year low infliximab doses (3 mg/Kg). However, in theory low-dose treated could develop subtherapeutic trough levels, infiximab antibodies, might loose response therapy. To verify this hypothesis pharmacokinetics clinical/endoscopic were checked a group the long term doses.Infliximab highly-sensitive CRP fecal calprotectin measured during 8-week interval 5 consecutive...
After a shift of Bacillus subtilis from aerobic to anaerobic growth conditions, nitrate ammonification and various fermentative processes replace oxygen-dependent respiration. Cell-free extracts prepared wild-type B. mutants the regulatory loci fnr resDE grown under conditions were compared by two-dimensional gel electrophoresis. Proteins involved in adaptation process identified their N-terminal sequence. Induction cytoplasmic lactate dehydrogenase (LctE) synthesis was dependent on resDE....
Hypogonadotropic hypogonadism (HH) is a heterogeneous disease caused by mutations in several genes. Based on the presence of hyposmia/anosmia it distinguished into Kallmann syndrome (KS) and isolated HH. The prevalence other developmental anomalies not well established.We studied 36 patients with HH (31 males, 5 females, mean age 41.5), 9 familial 27 sporadic (33 congenital, 3 adult-onset), physical examination, smell test (BSIT Sensonics), audiometry, renal ultrasound, magnetic resonance...
The identification of BRCA mutations plays a crucial role in the management hereditary cancer prevention and treatment. Nonetheless, BRCA-testing pancreatic (PC) patients is not universally introduced clinical practice. A retrospective analysis was conducted, firstly, to evaluate rate BRCA-positive families among those presenting family history PC besides breast and/or ovarian cancer. Secondly, relationship between pathogenic variants risk evaluated. Finally, characteristics developed were...
ABSTRACT Bacillus subtilis grows under anaerobic conditions utilizing nitrate ammonification and various fermentative processes. The two-component regulatory system ResDE the redox regulator Fnr are currently known parts of for adaptation. Mutation open reading frame ywiD located upstream respiratory reductase operon narGHJI resulted in elimination contribution nitrite dissimilation to growth. Significantly reduced (NasDE) activity was detected, while unchanged. Anaerobic induction nasDE...
Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy, with a steadily increasing incidence in last few decades worldwide. The predisposition to developing this by heterozygous state of rs2910164 within precursor miR-146a has been reported, but recently not confirmed. Interestingly, on same chromosome, almost 50 kb separate pre-miR-146a from pituitary tumor-transforming gene 1 (PTTG1), proto-oncogene involved several tumors, including cancers. In study, we analyzed, using...