A5057468067- Mosquito-borne diseases and control
- Malaria Research and Control
- Parasites and Host Interactions
- COVID-19 epidemiological studies
- Viral Infections and Vectors
- Vector-borne infectious diseases
- HIV Research and Treatment
- Global Maternal and Child Health
- Zoonotic diseases and public health
- Parasitic Diseases Research and Treatment
- Global Public Health Policies and Epidemiology
- Insects and Parasite Interactions
- Data-Driven Disease Surveillance
- Trypanosoma species research and implications
- SARS-CoV-2 and COVID-19 Research
- Pharmaceutical Economics and Policy
- Traditional and Medicinal Uses of Annonaceae
- Health Promotion and Cardiovascular Prevention
- COVID-19 Clinical Research Studies
- Click Chemistry and Applications
- HIV/AIDS drug development and treatment
- Iron Metabolism and Disorders
- Insect Resistance and Genetics
- Yersinia bacterium, plague, ectoparasites research
- Insect symbiosis and bacterial influences
Caribbean Public Health Agency
2024-2025
University of Guyana
2020-2025
Barcelona Institute for Global Health
2023
Universitat Internacional de Catalunya
2023
World Vision
2021
Australian National University
2021
Washington Center
2021
Antimalarial drug resistance has historically arisen through convergent de novo mutations in Plasmodium falciparum parasite populations Southeast Asia and South America. For the past decade Asia, artemisinins, core component of first-line antimalarial therapies, have experienced delayed clearance associated with several pfk13 mutations, primarily C580Y. We report that mutant emerged independently Guyana, genome analysis indicating an evolutionary origin distinct from Asia. Pfk13 C580Y...
Individual behavior, particularly choices about prevention, plays a key role in infection transmission of vector-borne diseases (VBDs). Since the actual risk is often uncertain, individual behavior influenced by perceived risk. A low perception likely to diminish use preventive measures (behavior). If good indicator risk, then it has important implications context disease elimination. However, more research needed improve our understanding human transmission. The objective this study explore...
Multiplexed PCR amplicon sequencing (AmpSeq) is an increasingly popular application for cost-effective monitoring of threatened species and managed wildlife populations, shows strong potential the genomic epidemiology infectious disease. AmpSeq data from microbes can inform disease control in multiple ways, such as by measuring drug resistance marker prevalence, distinguishing imported local cases, determining effectiveness therapeutics. We describe design comparative evaluation two new...
Abstract Purpose of Review Following Paraguay and Argentina, several countries from the Amazon region aim to eliminate malaria. To achieve this, all key affected vulnerable populations by malaria, including people working on gold mining sites, must be considered. What is situation malaria in these particular settings what are challenges? This literature review aims compile knowledge answer questions. Recent Findings The contexts which miners operate very heterogeneous: size localization...
Plasmodium falciparum is an apicomplexan parasite responsible for lethal cases of malaria. According to WHO recommendations, P are treated with artemisinin-based combination therapy including dihydroartemisinin-piperaquine. However, the emergence resistant parasites against dihydroartemisinin-piperaquine was reported in southeast Asia 2008 and, a few years later, suspected South America.
The Guiana Shield, a small region of South America, is currently one the main hotspots malaria transmission on continent. This Amazonian area characterised by remarkable socioeconomic, cultural, health, and political heterogeneity high degree regional cross-border population mobility, which has contributed to increase in past few years. In this context, cooperation control represents both challenge an indispensable initiative. Viewpoint advocates for creation cooperative mechanism...
parasites, the causal agents of malaria, are eukaryotic organisms that obligately undergo sexual recombination within mosquitoes. However, in low transmission settings where most mosquitoes become infected with only a single parasite clone, parasites recombine themselves, and clonal lineage is propagated rather than broken up by outcrossing. We investigated whether stochastic/neutral factors drive persistence abundance
Plasmodium parasites, the causal agents of malaria, are eukaryotic organisms that obligately undergo sexual recombination within mosquitoes. In low transmission settings, parasites recombine with themselves, and clonal lineage is propagated rather than broken up by outcrossing. We investigated whether stochastic/neutral factors drive persistence abundance falciparum lineages in Guyana, a country relatively malaria transmission, but only setting Americas which an important artemisinin...
SUMMARY BOX The prevalence of non-communicable diseases (NCDs) is growing worldwide and particularly pronounced in the Caribbean.
ABSTRACT Vector control remains an important strategy worldwide to prevent human infection with pathogens transmitted by arthropods. strategies rely on accurate identification of vector taxa along vector‐specific biological indicators such as feeding ecology, prevalence and insecticide resistance. Multiple ‘DNA barcoding’ protocols have been published over the past several decades support these applications, generally relying informal manual approaches BLAST assign taxonomic identity...
ABSTRACT Malaria in South America remains a serious public health problem. Anopheles ( Nyssorhynchus ) darlingi is the most important malaria vector across tropical Latin America. Vector-targeted disease control efforts require thorough understanding of mosquito demographic and evolutionary patterns. We present analyze whole genomes 1094 A. (median depth 18x) from six American countries. observe deep geographic population structure, high genetic diversity including thirteen putative...
Despite being a priority population in malaria elimination, there is scant literature on malaria-related behavior among gold miners. This study explores the prevalence and factors influencing prevention, care seeking treatment behaviors Guyana mining camps. A cross sectional survey was conducted adult miners living camps hinterland Regions 1 (Barima-Waini), 7 (Cuyuni-Mazaruni), 8 (Potaro-Siparuni). Multivariable logistic regressions explored associated with miners’ self-report of mosquito...
Guyana is one of four countries in the Latin American Region where lymphatic filariasis (LF) remains endemic. In preparation for introduction a new triple drug therapy regimen (ivermectin, diethylcarbamazine, and albendazole (IDA)) 2019, an acceptability study was embedded within sentinel site mapping regions to assess mass administration (MDA) coverage compliance, acceptability, perceptions about treatment disease. The results from this survey would inform rollout IDA 2019.Data collection...
BackgroundGuyana reported a significant rise in malaria between 2008 and 2014. As there was no evidence of impairment national control strategies, public health authorities attributed the surge to temporal increase gold mining activity forested regions. However, systematic analysis this association is lacking because difficulties associated with collecting reliable data for both mining. We aimed investigate international price Plasmodium falciparum transmission Guyana 2007 2019. also...
The first potential focus for artemisinin resistance in South America was recently confirmed with the presence of C580Y mutation Plasmodium falciparum kelch 13 gene (pfk13) Guyana.This study aimed to strengthen pfk13 monitoring Amazon basin countries, compile available data and evaluate risk spreading mutations.Sanger sequencing done on 862 samples collected between 1998 2019, a global map genotypes this region constructed. Then, mutations based P. case importation 2015 2018 within countries...
Although miners are a priority population in malaria elimination Guyana, scant literature exists on the drivers of malaria-related behaviour. This study explores relationship between gold miners' ideation and adoption care-seeking treatment behaviours including prompt care-seeking, testing, self-medication.Data from cross-sectional quantitative survey 1685 adult ages 18-59 years who live mining camps Regions 1, 7, 8. The analysis focused reported an episode fever past year (n = 745). Malaria...
Abstract In 2020, 77% of malaria cases in the Americas were concentrated Venezuela, Brazil, and Colombia. These countries are characterized by a heterogeneous landscape hotspots. Furthermore, political unrest Venezuela has led to significant cross-border population movement. Hence, aim this study was describe spatial patterns identify climatic drivers transmission along Venezuela-Brazil-Guyana border, focusing on Bolivar state, Roraima Brazil. Malaria case data, stratified species from 2016...
Time lags in reporting to national surveillance systems represent a major barrier for the control of infectious diseases, preventing timely decision making and resource allocation. This issue is particularly acute diseases like malaria, which often impact rural remote communities hardest. In Guyana, country located South America, poor connectivity among malaria-endemic regions hampers efforts, delays key challenge elimination. Here, we analyze 13 years malaria data, identifying correlates...
Abstract The malaria parasites Plasmodium falciparum and vivax differ in key biological processes associated clinical effects, but consequences on population-level transmission dynamics are difficult to predict. This co-endemic study from Guyana details important epidemiological contrasts between the species by coupling population genomics (1,396 spatiotemporally-matched parasite genomes) with sociodemographic analysis (nationwide patient census). We describe how P. forms large, interrelated...
Guyana remains one of four countries in the Americas endemic for lymphatic filariasis (LF). Elimination LF requires repeated annual mass drug administration (MDA) with sufficient levels coverage success. This study assesses acceptability and never treatment MDA using data from a routine assessment survey 2021. A subset individuals, over 20 years age (n = 2498), were selected to receive an expanded questionnaire examine factors associated treatment. Assessed include respondent demographics,...
Preventing vector-borne diseases (VBDs) mainly relies on effective vector control tools and strategies, which in turn depend population acceptance adherence. Inspired by the abundant recent literature SARS-COV-2, we investigate relationship between risk perception preventive behaviour for selected VBDs extent to is determined social norms. We use cross-sectional data collected from 497 individuals four regions of Guyana 2017. a conditional mixed process estimator with multilevel...
Abstract Multiplexed PCR amplicon sequencing (AmpSeq) is an increasingly popular application for cost-effective monitoring of threatened species and managed wildlife populations, shows strong potential genomic epidemiology infectious disease. AmpSeq data microbes can inform disease control in multiple ways, including measuring drug resistance marker prevalence, distinguishing imported from local cases, determining the effectiveness therapeutics. We describe design comparative evaluation two...