A5067261784- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Anesthesia and Neurotoxicity Research
- Nerve Injury and Rehabilitation
- Fetal and Pediatric Neurological Disorders
- Electrospun Nanofibers in Biomedical Applications
- Neonatal Health and Biochemistry
- Cerebral Palsy and Movement Disorders
- Flow Measurement and Analysis
- Exercise and Physiological Responses
- Congenital Heart Disease Studies
- Neonatal and Maternal Infections
- Fluid Dynamics and Turbulent Flows
- Structural Integrity and Reliability Analysis
- Pregnancy and preeclampsia studies
- Inflammasome and immune disorders
- Circadian rhythm and melatonin
- Domain Adaptation and Few-Shot Learning
- Diabetic Foot Ulcer Assessment and Management
- MicroRNA in disease regulation
- Sepsis Diagnosis and Treatment
- Sleep and Wakefulness Research
Royal College of Surgeons in Ireland
2022-2024
Mayo Clinic
2023
Ollscoil na Gaillimhe – University of Galway
2022-2023
WinnMed
2023
Science Foundation Ireland
2022
Mayo Clinic in Arizona
2022
Trinity College Dublin
2019-2021
St. James's Hospital
2021
National University of Ireland
2020-2021
Coombe Women & Infants University Hospital
2019-2020
Cytokines are possible mediators of neuroinflammation and associated with adverse outcome in neonatal encephalopathy (NE). Our aim was to explore cytokine response children Neonatal Encephalopathy (NE) at school age compared age-matched controls.Follow up age, who had NE controls were assessed for their responses neurodevelopment outcome. Pro- anti-inflammatory cytokines the serum, [Interleukin (IL)-1α, IL-1β, IL-2, IL-6, IL-8, IL-18, Tumor necrosis factor (TNF)-α, TNF β, Interferon (IFN)-γ,...
Aim To examine pro‐ and anti‐inflammatory cytokines in children with cerebral palsy (CP) at baseline response to endotoxin (lipopolysaccharide), correlate outcomes compared age‐matched comparisons, evaluate their ability mount an immune response. Method Serum were assessed 12 (eight males, four females; mean age 10y 1mo [SD 1y 8mo], 6–16y) CP against comparisons 9y 1mo]). Pro‐ (interleukin‐1β, interleukin‐2, interleukin‐6, interleukin‐8, interleukin‐10, interleukin‐18, tumour necrosis factor...
Abstract Here, we report the effect of newly regenerated axons via scaffolds on reorganization spinal circuitry and restoration motor functions with epidural electrical stimulation (EES). Motor recovery was evaluated for 7 weeks after transection following implantation seeded neurotrophin producing Schwann cell rapamycin microspheres. Combined treatment EES-enabled stepping led to functional improvement compared groups scaffold or EES, although, number across not different between groups....
Aim: To investigate the relationship between cytokines associated with innate immune cell activation and brain injury outcome in infants NE compared to neonatal controls. Methods: Serum CSF biomarkers activated neutrophils monocytes [Interleukin-8 (IL-8) Granulocyte-Macrophage-Colony-Stimulating-Factor (GM-CSF)] were serially measured using duplex immunoassays on days 1, 3 7 term newborns Results grade of encephalopathy, seizures, MRI imaging, mortality Bayley Score Infant Toddler...
Neonatal encephalopathy (NE) is characterized by altered neurological function in term infants and inflammation plays an important pathophysiological role. Inflammatory cytokines interleukin (IL)-1β, IL-1ra IL-18 are activated the nucleotide-binding oligomerization domain (NOD)-, leucine-rich repeat (LRR)- NOD-like receptor protein 3 (NLRP3) inflammasome; furthermore, we aimed to examine role of inflammasome multiprotein complex involved proinflammatory responses from newborn period...
Background: Neonatal encephalopathy (NE) is associated with adverse neurodevelopmental outcome and linked systemic inflammation. Pro-inflammatory anti-inflammatory cytokines are known to play a role in the pathology of NE by activating innate immune cells. Methods: Eighty-seven infants were enrolled including 53 whom 52 received therapeutic hypothermia (TH) 34 term infant healthy controls (TC). Whole blood sampling was performed first 4 days life, 14-spot ELISA Multiplex Cytokine Array...
The spinal cord has a poor ability to regenerate after an injury, which may be due cell loss, cyst formation, inflammation, and scarring. A promising approach treating injury (SCI) is the use of biomaterials. We have developed novel hydrogel scaffold fabricated from oligo(poly(ethylene glycol) fumarate) (OPF) as 0.08 mm thick sheet containing polymer ridges cell-attractive surface on other side. When cells are cultured OPF via chemical patterning, attach, align, deposit ECM along direction...
Neonatal encephalopathy (NE) is associated with an increased risk of multi-organ injury. The lack standardised definitions for dysfunction in NE hinders accurate quantification these complications.A simple neonatal scoring (MODE) system was created to include the cardiovascular, respiratory, gastrointestinal, haematological and neurological systems a maximum score 15. MODE then compared grade NE, Bayley Scales Infant Development (Bayley-III) at 2 years age mortality. used as it gave...
Objective: Sepsis is major cause of morbidity and mortality in the Pediatric Intensive Care Unit (PICU). PICU patients may develop transient immune deficiency during sepsis. Activated Protein C (APC) has significant anti-inflammatory cytoprotective effects. Clinical trials APC adult sepsis initially showed improved outcome but recent no benefit adults or children. We aimed to assess effects treatment on innate responses Design Subjects: compared neutrophil monocyte lipopolysaccharide (LPS)...
Abstract We report the effect of newly regenerated neural fibers via bioengineered scaffold on reorganization spinal circuitry and restoration motor functions with electrical epidural stimulation (EES) after transection (ST). Restoration across multiple modalities was evaluated for 7 weeks ST implanted seeded Schwann cells, producing neurotrophic factors rapamycin microspheres. Gradual improvement in EES-facilitated stepping observed animals scaffolds, although, no significant difference...
ABSTRACT Epileptogenesis is the process that leads brain into epileptic activity. Clinical evidence shows ∼90% of people with epilepsy present rhythmicity in timing their seizures presentation. However, whether circadian clock a key player during epileptogenesis remains unknown. Here, we triggered mice by intra-amygdala injection kainic acid and profiled RNA sequencing hippocampal diurnal mRNA rhythmicity. We show largely reshapes transcriptomic molecular machinery inhibited due to...
Abstract Background: Cytokines are possible mediators of neuroinflammation and associated with adverse outcome in neonatal encephalopathy (NE) . Our aim was to explore cytokine response children Neonatal Encephalopathy at school age compared age-matched controls. Method: Follow up age, who had NE controls were assessed for their responses neurodevelopment outcome. Pro- anti-inflammatory cytokines the serum, [Interleukin (IL)-1α, IL-1β, IL-2, IL-6, IL-8, IL-18, Tumor necrosis factor (TNF)-α,...
Abstract Background: Cytokines are possible mediators of neuroinflammation and associated with adverse outcome in neonatal encephalopathy (NE) . Our aim was to explore cytokine response children Neonatal Encephalopathy at school age compared age-matched controls. Method: Follow up age, who had NE controls were assessed for their responses neurodevelopment outcome. Pro- anti-inflammatory cytokines the serum, [Interleukin (IL)-1α, IL-1β, IL-2, IL-6, IL-8, IL-18, Tumor necrosis factor (TNF)-α,...
Abstract Objective: Cytokines are possible mediators of neuroinflammation and associated with adverse outcome in neonatal encephalopathy (NE). Our aim was to explore cytokine response children Neonatal Encephalopathy (NE) at school age compared age-matched controls. Method: Follow up age, who had NE controls were assessed for their responses neurodevelopment outcome. Pro- anti-inflammatory cytokines the serum, [Interleukin (IL)-1α, IL-1β, IL-2, IL-6, IL-8, IL-18, Tumor necrosis factor...
Abstract The spinal cord has poor ability to regenerate after injury, which may be due cell loss, cyst formation, inflammation, and scarring. A promising approach treat injury (SCI) is the use of biomaterials. We have developed a novel hydrogel scaffold fabricated from oligo(poly(ethylene glycol) fumarate) (OPF) as 0.08 mm thick sheet containing polymer ridges cell-attractive surface chemistry on other side. When cells are cultured OPF with chemical patterning, attach, align, deposit ECM...
Abstract Hypoxic ischaemic injury (HIE) in the neonatal brain has significant consequences on neurodevelopment and increases occurrence of neurological deficits infants. HIE is also a leading cause seizures. Therapeutic options for treatment are very limited. Hypoxia-ischemia directly damages tissue primary-wave which activates cascade events triggering local systemic inflammatory responses, driven by innate immune system, contribute to secondary-wave taking place as early 6 hours...