A5026049062- Food Allergy and Anaphylaxis Research
- Contact Dermatitis and Allergies
- Allergic Rhinitis and Sensitization
- Xenotransplantation and immune response
- Animal health and immunology
- Mast cells and histamine
- Urticaria and Related Conditions
- Drug-Induced Adverse Reactions
- Dermatology and Skin Diseases
- Occupational exposure and asthma
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Proteins in Food Systems
- Healthcare and Venom Research
- Monoclonal and Polyclonal Antibodies Research
- Hemostasis and retained surgical items
- Herpesvirus Infections and Treatments
- Biotin and Related Studies
- Rabies epidemiology and control
- Venomous Animal Envenomation and Studies
- Polydiacetylene-based materials and applications
Luxembourg Institute of Health
2016-2024
Odense University Hospital
2017
Laboratoire National de Santé
2009-2011
Serum IgE antibodies directed at galactose-α-1,3-galactose (α-Gal) are associated with a novel form of delayed anaphylaxis occurring upon consumption red meat or innards. Pork kidney is known as the most potent trigger this syndrome, but culprit allergens have not yet been identified. The aim study was identification and characterization pork proteins mediating anaphylactic reactions through specific to α-Gal.A cohort 59 patients α-Gal screened by immunoblot for IgE-reactive in kidney....
Abstract Background The α‐Gal syndrome (AGS) is characterized by the presence of specific IgE‐antibodies to carbohydrate galactose‐α‐1,3‐galactose (α‐Gal). Sensitization has been associated with tick bites and individuals exposed ticks have an elevated risk sensitization. aim this study was analyze IgG IgE antibody responses in a high‐risk cohort forestry employees (FE) Luxembourg. Methods Questionnaires serum samples FE from Luxembourg ( n = 219) were retrospectively analyzed. quantified...
<i>Background:</i> Animal-derived proteins are implicated in primary food allergies, but also inhalant allergies with secondary allergy symptoms. The objective of this study was to define the allergen(s) a case chicken meat, which developed person previously sensitized pork after occupational exposure. <i>Methods:</i> A 42-year-old female history reported rhinitis, asthma, dysphonia and conjunctivitis 30 min ingestion chicken. Skin tests were positive meat. Protein...
Cite this as : C. Hilger, K. Swiontek, S. Kler, Diederich, Lehners, L. Vogel, Vieths and F. Hentges, Clinical & Experimental Allergy , 2011 (41) 899–908. Summary Background Guinea‐pigs, classical laboratory animals now often kept pets, regularly elicit important allergic reactions. Two guinea‐pig allergens have been described previously to some extent; however, biomolecular immunological data are lacking. Objective To identify major allergens, produce them recombinant proteins define...
Allergens from furry animals frequently cause sensitization and respiratory allergic diseases. Most relevant mammalian allergens belong either to the protein family of lipocalins or secretoglobins. Their mechanism remains largely unresolved. Mammalian lipocalin secretoglobin are associated with a function in chemical communication that involves abundant secretion into environment, high stability ability transport small volatile compounds. These properties likely contribute concomitantly...
Alpha-gal (Galα1-3Galβ1-4GlcNAc) is a carbohydrate with the potential to elicit fatal allergic reactions mammalian meat and drugs of origin. This type allergy induced by tick bites, therapeutic options for this skin-driven food are limited avoidance allergen treatment symptoms. Thus, better understanding immune mechanisms resulting in sensitization through skin crucial, especially case which underlying responses poorly understood. We aimed establish mouse model alpha-gal in-depth immunologic...
Immediate and delayed-type hypersensitivity reactions to pet-borne allergens are common in atopic diseases. In dermatitis (AD), controversy surrounds the contribution disease of cross-reactivity self-proteins. Human cystatin A cat allergen Fel d 3 belong cystatins, an evolutionary conserved protein family. The objective present study was assess crossreactivity between mammalian cystatins analyze T-cell responses AD patients sensitized pet dander.cDNA coding for dog cloned from skin. Sera 245...
Furry pets are beloved companion animals; horse riding is a popular leisure activity. So-called hypoallergenic animals have gained high interest as sensitization to animal dander and allergy furry widespread. Allergen immunotherapy still limited, allergen avoidance in addition symptomatic pharmaceutical treatment often the only available option. Patients with an existing or atopic background seeking for alternative. This review summarizes current knowledge discusses future strategies.
The alpha-Gal epitope (α-Gal) with the determining element galactose-α1,3-galactose can lead to clinically relevant allergic reactions and rejections in xenotransplantation. These immune develop because humans are devoid of this carbohydrate due evolutionary loss enzyme α1,3-galactosyltransferase (GGTA1). In addition, up 1% human IgG antibodies directed against α-Gal, but stimulus for induction anti-α-Gal is still unclear. Commensal bacteria have been suggested as a causal factor α-Gal...
Abstract Background Furry animals are an important source of indoor allergens. Diagnosis allergy to small pets such as guinea‐pigs still relies on animal dander extracts which do not allow define the primary sensitization source. Objective To identify major guinea‐pig allergens and evaluate their potential marker for in vitro IgE‐diagnosis comparison with extracts. Methods A group patients allergic ( n = 29) a cat dog 30) were recruited study. panel four lipocalin was expressed recombinant...
Table 1.Tryptase level, total IgE and specific titers of the patient's serum from day anaphylaxis.
ORAL ABSTRACTS Symposium 1: Biochemistry, structure and environment of the allergen: what makes a protein an allergen? O1 Two cell-membrane peptidases carrying galactose-alpha-1,3-galactose are implicated in delayed anaphylactic reactions upon pork kidney ingestion patients with IgE-antibodies to alpha-Gal Christiane Hilger, Kyra Swiontek, Jörg Fischer, François Hentges, Lehners, Martine Morisset, Bernadette Eberlein, Tilo Biedermann, Markus Ollert O2 Structure solution Pla l 1 suggests...
Background: α-Gal syndrome is characterized by specific IgE (sIgE) antibodies to the carbohydrate galactose-α-1,3-galactose (α-Gal) and delayed onset of allergic symptoms after ingestion mammalian meat. While tick bites are assumed mediate sensitization, immune response has not yet been investigated. Objective: To investigate peripheral in humans over time. Methods: In a longitudinal cohort study, immunological reactions associated with (Ixodes species) were analyzed within 1 day (V1), 2...