A5028792120- Cell Image Analysis Techniques
- Advanced Biosensing Techniques and Applications
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Single-cell and spatial transcriptomics
- Amino Acid Enzymes and Metabolism
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Suicide and Self-Harm Studies
- Lung Cancer Research Studies
- Genetics, Bioinformatics, and Biomedical Research
- Genomic variations and chromosomal abnormalities
- Natural Language Processing Techniques
- Chronic Myeloid Leukemia Treatments
- Photoacoustic and Ultrasonic Imaging
- Neuroendocrine Tumor Research Advances
- Homicide, Infanticide, and Child Abuse
- Authorship Attribution and Profiling
- Oral and gingival health research
- Cancer Research and Treatments
- Grief, Bereavement, and Mental Health
- Genetic factors in colorectal cancer
- Bladder and Urothelial Cancer Treatments
- Advanced MRI Techniques and Applications
- AI in cancer detection
National Cancer Institute
2024-2025
National Institutes of Health
2024-2025
University of California, Los Angeles
2021-2024
Circle (United States)
2022
Google (United States)
2012
The iterative bleaching extends multiplexity (IBEX) Knowledge-Base is a central portal for researchers adopting IBEX and related 2D 3D immunofluorescence imaging methods. design of the modeled after efforts in open-source software community includes three facets: development platform (GitHub), static website, service data archiving. facilitates practice open science throughout research life cycle by providing validation recommended non-recommended reagents, e.g., primary secondary...
Multiplexed imaging is a powerful approach in spatial biology, although it complex, expensive and labor-intensive. Here, we present the IBEX Knowledge-Base, central resource for reagents, protocols more, to enhance knowledge sharing, optimization innovation of proteomics techniques.
The iterative bleaching extends multiplexity (IBEX) Knowledge-Base is a central portal for researchers adopting IBEX and related 2D 3D immunofluorescence imaging methods. design of the modeled after efforts in open-source software community includes three facets: development platform (GitHub), static website, service data archiving. facilitates practice open science throughout research life cycle by providing validation recommended non-recommended reagents, e.g., primary secondary...
The spatial heterogeneity of the tumor microenvironment (TME) is a critical determinant therapeutic response, particularly for immune-oncology agents, where success depends on distribution specific immune cell subpopulations. Over past decade, multiple sophisticated technologies have been introduced to achieve detailed resolution TME using two-dimensional sections from either formalin-fixed, paraffin-embedded (FFPE) or fixed-frozen tissues. While these thin are easier procure and analyze,...
Abstract Cholangiocarcinoma (CCA) is a deadly malignancy with an evolving therapeutic landscape. Although nucleic acid-based evaluations have unveiled some druggable targets, limited options are available for the majority of patients this disease. We therefore evaluated biliary exosomes by mass spectrometry from 16 CCA, which revealed 17-fold enhancement nuclear export protein XPO7 in CCA-derived exosomes. IHC analysis expression CCA tumors 170 unexpectedly demonstrated intense cytoplasmic...
There is increasing attention to suicides that occur in view of others, as these deaths can cause significant psychological impact on witnesses. This study illuminates characteristics witnessed and compares non-witnessed suicides. We develop a codable definition what constitutes (vs. non-witnessed) suicide. Our data include sample 1200 suicide descriptions from the 2003–2017 National Violent Death Reporting System (NVDRS). first developed criteria identify probable cases The coding scheme...
Abstract Introduction: Metastatic outgrowth and colonization requires that disseminated tumor cells simultaneously compensate for alterations in nutrient availability, counteract oxidative stress, evade host innate adaptive immune surveillance. The mechanistic underpinnings of how these vital processes are coordinated is not understood. Experimental procedures: Using intrasplenic injection (liver metastases) tail vein (lung metastases), we employed a gain-of-function cDNA screen mice to...