A5080573887- Animal Virus Infections Studies
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- Nail Diseases and Treatments
- Research in Cotton Cultivation
- Clinical practice guidelines implementation
- Cancer-related gene regulation
- Virus-based gene therapy research
- Chronic Lymphocytic Leukemia Research
- Hepatitis C virus research
- Polyomavirus and related diseases
- Periodontal Regeneration and Treatments
- Cancer, Lipids, and Metabolism
- Viral Infections and Immunology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Mesenchymal stem cell research
- Cutaneous lymphoproliferative disorders research
- Emergency and Acute Care Studies
- Immunotherapy and Immune Responses
- Viral Infections and Outbreaks Research
- Migraine and Headache Studies
- RNA modifications and cancer
- Dermatological diseases and infestations
Duke-NUS Medical School
2021-2024
National University of Singapore
2023
John Wiley & Sons (United States)
2023
Liechtenstein Institute
2023
Beckman Laser Institute and Medical Clinic
2023
University of California, Irvine
2023
Massachusetts General Hospital
2023
University of Hong Kong
2023
University of Nevada, Las Vegas
2023
National University Hospital
2013-2019
Exportin-1 (XPO1) controls the nucleo-cytoplasmic trafficking of several key growth regulatory and tumor suppressor proteins. Nuclear export blockade through XPO1 inhibition is a target for therapeutic in many cancers. Studies have suggested upregulation as an indicator poor prognosis gastric cancer. In current study, we investigated anti-tumor efficacy selective inhibitors nuclear (SINE) compounds KPT-185, KTP-276 clinical stage selinexor (KPT-330) was found to be overexpressed cancer...
Platinum based therapy is commonly used in the treatment of advanced gastric cancer. However, resistance to chemotherapy a major challenge that causes marked variation individual response rate and survival rate. In this study, we aimed identify expression GTSE1 its correlation with cisplatin cancer cells. Methylation profiling was carried out tissue samples from patients before undergoing neoadjuvent using docetaxel, 5FU (DCX) cell lines. The between methylation cells determined by RT-PCR...
Swine are a primary source for the emergence of pandemic influenza A viruses. The intensification swine production, along with global trade, has amplified transmission and zoonotic risk virus (swIAV). Effective surveillance is essential to uncover emerging strains; however gaps remain in our understanding swIAV genomic landscape Southeast Asia. More than 4,000 nasal swabs were collected from pigs Cambodia, yielding 72 IAV-positive samples by RT-qPCR 45 sequences. We unmasked cocirculation...
Although gemcitabine is highly active in several cancer types, intrinsic and acquired drug resistance remains a major challenge. Overexpression of Bcl-2 has been associated with resistance. The aim this study to determine whether gossypol can overcome cell lines high level expression combination therapy. Our demonstrated that 10 derived from different cancers, baseline was observed were resistant (GEM-R). Furthermore, synergistic effect therapy gemcitabine-resistant (GEM-R) expression, but...
Gastric cancer (GC) is the second leading cause of global mortality worldwide. However, molecular mechanism underlying its carcinogenesis and drug resistance not well understood. To identify novel functionally important genes that were differentially expressed due to combinations genetic epigenetic changes, we analyzed datasets containing genome-wide mRNA expression, DNA copy number alterations methylation status from 154 primary GC samples 47 matched non-neoplastic mucosa tissues Asian...
: F-box/WD repeat-containing protein 5 (FBXW5) is a member of the FBXW subclass F-box proteins. Despite its known function as component Skp1-Cullin-F-box (SCF) ubiquitin ligase complex, role FBXW5 in gastric cancer tumorigenesis and metastasis has not been investigated. The present study investigates metastasis, well regulation key signaling pathways cancer; using in-vitro knockdown/overexpression cell line in-vivo models. In-vitro knockdown results decrease proliferation cycle progression,...
The highly pathogenic (HPAI) avian influenza A(H5N1) viruses have undergone reassortment with multiple non-N1-subtype neuraminidase genes since 2008, leading to the emergence of H5Nx viruses. established themselves quickly in birds and disseminated from China Africa, Middle East, Europe North America. Multiple genetic clades successively evolved through frequent mutations reassortment, posing a continuous threat domestic poultry causing substantial economic losses. Live bird markets are...
Abstract The recent outbreaks of highly pathogenic avian influenza A(H5N1) virus in North and South America, including widespread infection cattle the United States, calls for an urgent assessment host range A viruses, particularly subtypes pandemic concern. We conducted a serological survey binding antibodies to B viruses goats (n=452) sheep (n=329) Pakistan found high seropositive rates hemagglutinin (HA) (AIV) H5 (23.9–34.0%), H7 (13.9– 37.1%), H9 (17.0–34.7%). In contrast, there were low...
Bats are the reservoir for numerous human pathogens, including coronaviruses. Despite many coronaviruses having descended from bat ancestors, little is known about virus-host interactions and broader evolutionary history involving bats. Studies have largely focused on zoonotic potential of with few infection experiments conducted in cells. To determine genetic changes derived replication cells possibly identify novel pathways virus emergence, we serially passaged six 229E isolates a newly...
Hepatitis caused by mouse hepatitis virus (MHV-A59), a murine coronavirus, is accompanied direct infection and replication of within the liver. We demonstrate here that aminoglycoside hygromycin B able to eliminate MHV-A59 from peritoneal macrophages cultured liver cells in vitro also reduce levels necrotic foci vivo.
Infection of mouse L-2 fibroblasts with hepatitis virus (MHV) results in strong inhibition host cell protein synthesis. Since it has been suggested other systems that translational control is modulated by changes the intracellular ionic environment, we investigated possible occurrence similar during MHV infection. Membrane permeability to extracellular sodium ions was measured culturing MHV-infected cells presence 22Na+. Sodium influx into rose dramatically from 4 6 h post-infection. This...
SUMMARY The expression of mouse hepatitis virus (MHV) E2-specific mRNA, the E2 polypeptide and its associated cell fusing activity was monitored in various types inoculated with a recombinant vaccinia virus, designated vMS containing gene. results suggest that host permissiveness to MHV infection correlates cellular susceptibility membrane fusion mediated by glycoprotein. In addition, we utilized genetic approach analysis functions involved determining MHV. By using chemical mutagen ethyl...
SUMMARY The relatively cell impermeable hygromycin B was found to inhibit viral but not cellular protein synthesis when added cultures of murine hepatitis virus (MHV)-infected or mock-infected mouse L-2 fibroblasts. Membrane permeability, as judged by influx sodium ions, has previously been demonstrated be an MHV E2 glycoprotein-mediated, cytopathic effect infection in cells. It is therefore likely that the selective on a reflection increased drug penetration into virus-infected Using marker...
Abstract Bats are the reservoir for numerous human pathogens including coronaviruses. The factors leading to emergence and sustained transmission of coronaviruses in humans poorly understood. An outstanding question is how can accomplish a host switch with likely mismatch between surface protein spike bat virus cellular receptor at time zoonotic transmission. To identify potential novel evolutionary pathways emergence, we serially passaged six 229E isolates newly established Rhinolophus...
Abstract Swine are a primary source for the emergence of pandemic influenza A viruses. The intensification swine production, along with global trade, has amplified transmission and zoonotic risk virus (swIAV). Effective surveillance is essential to uncover emerging strains, however gaps remain in our understanding swIAV genomic landscape Southeast Asia. By collecting more than 4,000 nasal swabs sera from pigs Cambodia, we unmasked co-circulation multiple lineages genetically diverse concern....
Abstract Gemcitabine is an anticancer agent used in breast, non-small cell lung, pancreatic and ovarian cancer. However, many cancers have been showed to be resistant gemcitabine. Recent studies demonstrated that gemcitabine resistance can overcome when combined with gossypol. Gossypol inhibitor of Bcl-2 induces apoptosis various cancer lines. The aim our study was determine whether gossypol via its interaction the protein. IC50 gemcitabine, as well baseline expression were determined 10...
<h3>Background/Aims</h3> Kerion is a scalp condition that occurs in severe cases of ringworm (tinea capitis) with the highest prevalence children 3 to 10 years age. It appears as an inflamed, thickened, pus-filled area, scaly spots or patches broken hair on scalp. A kerion treated oral antifungal medicines because fungus grows deep into follicle where topical creams and lotions cannot penetrate. Oral corticosteroids are also started lesions tender reduce inflammation. usually associated...
<h3>Background</h3> Triage systems are utilised internationally to rapidly assess patients and subsequently categorise based on the need for medical intervention. A functioning triage system is essential patient safety flow in an emergency department. University Hospital Limerick Paediatric Emergency Department (UHL PED) utilises Manchester System which contains 10 paediatric charts with discriminators caseload categories 1 – 5. It not role of establish requirement admission; however it aim...