A5036035330- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Infectious Aortic and Vascular Conditions
- Orthopedic Surgery and Rehabilitation
- Elbow and Forearm Trauma Treatment
- Nerve injury and regeneration
- Vascular Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Shoulder Injury and Treatment
- Venous Thromboembolism Diagnosis and Management
- Nitric Oxide and Endothelin Effects
- Cardiac and Coronary Surgery Techniques
- Nerve Injury and Rehabilitation
- Pain Mechanisms and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Renal and Vascular Pathologies
- Bone health and treatments
- Bone fractures and treatments
- X-ray Diffraction in Crystallography
- Inflammatory Biomarkers in Disease Prognosis
- Rheumatoid Arthritis Research and Therapies
- Crystallization and Solubility Studies
- Vascular anomalies and interventions
- Bone health and osteoporosis research
Tokyo Medical University
2013-2025
Osaka University
2002-2025
Osaka University Hospital
2024
Ministry of Health Labour and Welfare
2024
Rutgers, The State University of New Jersey
2009-2023
Rutgers New Jersey Medical School
2008-2023
Japanese Circulation Society
2023
Society for Vascular Surgery
2023
Tokyo Medical University Hospital
2009-2020
Aichi Medical University
2020
Nitrates such as nitroglycerin (GTN) and nitric oxide donors S-nitrosothiols are clinically vasoactive through stimulation of soluble guanylyl cyclase (sGC), which produces the second messenger cGMP. Development nitrate tolerance, after exposure to GTN for several hours, is a major drawback widely used cardiovascular therapy. We recently showed that causes S-nitrosylation sGC, directly desensitizes sGC by oxide. tested hypothesis desensitization mechanism tolerance. Our results established...
Postoperative adhesion around nerves sometimes results in sensory and motor dysfunctions. To prevent these disorders, we have developed an electrospun nanofiber sheet incorporating methylcobalamin (MeCbl), active form of vitamin B12 with anti-inflammatory neuroregenerative effects. This study aimed to investigate the neuroprotective effects MeCbl sheets against postoperative compare those porcine small intestinal submucosa (SIS) using a rat sciatic nerve model. Behavioral...
Our primary concern was the risk of overtreating elderly patients with endovascular aneurysm repair (EVAR) for abdominal aortic aneurysm. We investigated association between age at time EVAR and all-cause mortality in Japan's aging population by stratifying into groups. Data from 175 who underwent elective 2012 to 2016 were analyzed. Patients categorized 3 groups: <75 years, 75-84 ≥85 based on healthy life expectancy average expectancy. Survival rates factors assessed across these patient...
Malunion after distal radial fractures with intra-articular and extra-articular deformities is difficult to treat. We report two cases of simultaneous corrective osteotomies for malunion radius using a patient-matched surgical guide plate (patient-matched instruments [PMIs]) created based on preoperative computer simulation. Both patients experienced pain limited range motion in the wrist forearm. Three-dimensional models were CT simulate osteotomy. Two types PMIs correct deformity step-off....
The molecular mechanisms of endothelial nitric oxide synthase (eNOS) regulation microvascular permeability remain unresolved. Agonist-induced internalization may have a role in this process. We demonstrate here that eNOS is required to deliver NO subcellular locations increase monolayer macromolecules. Using dominant-negative mutants dynamin-2 (dyn2K44A) and caveolin-1 (cav1Y14F), we show anchoring eNOS-containing caveolae plasma membrane inhibits hyperpermeability induced by...
Although the automatic diagnosis of fractures using artificial intelligence (AI) has recently been reported to be more accurate than those by orthopedics specialists, big data with at least 1000 images or are required for deep learning convolutional neural network (CNN) improve diagnostic accuracy. The aim this study was develop an AI system capable diagnosing distal radius high accuracy even when relatively small use bi-planar X-rays images.VGG16, a learned image recognition model, used as...
Termination of microvascular hyperpermeability has been so far accepted to be a passive result the removal applied proinflammatory agonists. We provide in vivo and vitro evidence that 1) inactivation is an actively regulated process, 2) agonists (PAF VEGF) stimulate initiate endothelial mechanisms terminate hyperpermeability, 3) eNOS location-translocation critical activation-inactivation cascade hyperpermeability.
The purpose of this retrospective study is to clarify the difference in plantar pressure distribution during walking and related patient-based outcomes between forefoot joint-preserving arthroplasty resection-replacement patients with rheumatoid arthritis (RA).Four groups were recruited. Group1 included 22 feet 11 healthy controls (age 48.6 years), Group2 36 28 RA deformed non-operated 64.8 years, Disease activity score assessing joints CRP [DAS28-CRP] 2.3), Group3 27 20 metatarsal head 60.7...
Neurotropin® (NTP), a non-protein extract of inflamed rabbit skin inoculated with vaccinia virus, is clinically used for the treatment neuropathic pain in Japan and China, although its effect on peripheral nerve regeneration remains to be elucidated. The purpose this study was investigate effects NTP Schwann cells (SCs) vitro vivo, which play an important role regeneration. In SCs, upregulated protein kinase B (AKT) activity Krox20 downregulated extracellular signal-regulated kinase1/2 under...
Abstract Background Aortoesophageal fistula (AEF) is a relatively rare condition that often life-threatening. Secondary AEF complication of previous surgery, which can be more critical and challenging than primary AEF. The number secondary increasing due to increase in the thoracic endovascular aortic repair (TEVAR). Although TEVAR has become successful alternative surgical strategy for aneurysms, after might other because severe adhesion between esophagus residual wall. Methods This study...
The purpose of this study was to determine the predictive ability neutrophilia, lymphocytopenia, and neutrophil-lymphocyte ratio (NLR) for overall mortality after EVAR AAA.Data on patients with AAA treated by between March 2012 December 2016 were obtained from a prospectively maintained database at Tokyo Medical University Hospital, Tokyo, Japan. NLR calculated dividing absolute neutrophil count lymphocyte count. A cut-off value total WBC count, determined according receiver operating...
Facial paralysis results in the decline generation of facial expressions and is attributed to several causes. Intractable has a poor prognosis, new treatments are required. Reactive oxygen species can inhibit peripheral nerve regeneration after injury. Therefore, administration an appropriate antioxidant promote regeneration. Silicon (Si)-based agents react with water generate hydrogen. Oral Si-based effectively alleviate symptoms disease models associated oxidative stress. Thus, we orally...
BackgroundVarious methods of two or three-dimensional (3D) corrective osteotomy for cubitus varus deformity have been reported. However, whether 3D correction is necessary controversial because technical difficulties and surgical complications. This study introduced simulations printing technology against deformities. Moreover, recent studies on the application these technologies were reviewed.MethodsThe amount was calculated based difference in shape between affected side contralateral...
Three-dimensional (3D) capacity for remodelling in cubitus varus deformity (CVD) after paediatric supracondylar humeral fractures (PSHFs) remains unelucidated. This study investigated patterns PSHFs by examining 3D distribution over time injury.
Ultra-fine bubbles (<200 nm in diameter) have several unique properties and been tested various medical fields. The purpose of this study was to investigate the effects oxygen ultra-fine (OUBs) on a sciatic nerve crush injury (SNC) model rats. Rats were intraperitoneally injected with 1.5 mL saline, OUBs diluted or nitrogen (NUBs) saline three times per week for 4 weeks four groups: (1) control, (sham operation + saline); (2) SNC, (crush (3) SNC+OUB, OUB-saline); (4) SNC+NUB, NUB-saline)....
We aimed to review 50 consecutive Japanese abdominal aortic aneurysm (AAA) and common iliac (CIAA) patients evaluate the 2-year outcomes, particularly endoleak sac shrinkage, of Endurant stent graft.Between June 2012 January 2014, AAA CIAA underwent EVAR with graft. Clinical outcomes overall survival, aneurysm-related secondary intervention-free survival were analyzed; endoleaks changes also evaluated.The Kaplan-Meier estimates for 85.4%, 97.7% one device-related death, 84.9%, respectively....