A5029911574- Colorectal Cancer Treatments and Studies
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Screening and Detection
- Pancreatitis Pathology and Treatment
- RNA Research and Splicing
- Diversity and Career in Medicine
- Intraperitoneal and Appendiceal Malignancies
- Economic and Financial Impacts of Cancer
- Neuroendocrine Tumor Research Advances
- Nanoparticle-Based Drug Delivery
- Gallbladder and Bile Duct Disorders
- Palliative Care and End-of-Life Issues
- Genetic factors in colorectal cancer
- Patient-Provider Communication in Healthcare
- Abdominal vascular conditions and treatments
- Pituitary Gland Disorders and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ethics in Clinical Research
- Patient Dignity and Privacy
- Innovations in Medical Education
- Medical Education and Admissions
Yale University
2018-2024
Yale Cancer Center
2021-2024
Fistula Foundation
2020
Mount Sinai Hospital
2019
SUNY Downstate Health Sciences University
2014-2019
Saint Barnabas Medical Center
2019
Columbia University Irving Medical Center
2019
State University of New York
2019
Pancreatic ductal adenocarcinoma (PDA) continues to be one of the deadliest cancers due absence effective treatment. Curaxins are a class small molecules with anti-cancer activity demonstrated in different models cancer mice. The lead curaxin compound, CBL0137, recently entered Phase I clinical trials. modulate several important signaling pathways involved pathogenesis PDA through inhibition chromatin remodeling complex FACT. FACT is overexpressed multiple types tumor, highest rate...
Background: Colorectal cancer (CRC) incidence is rising in the young, yet age of those affected not clearly defined. In this study, we identify such cohorts and define clinicopathological features early-onset colon rectal cancers. Methods: The Surveillance, Epidemiology End Results Program (SEER) database was queried to compare characteristics cancers diagnosed during 1973-1995 with 1995-2014. Results: We identified 430,886 patients From 1995-2014, increased aged 20-44 years, while ≤54...
N6-methyladenosine (m6A) plays an important role in many cancers. However, few studies have examined the of m6A colorectal CRC. To examine effect on CRC, we studied genome 591 CRC cases from The Cancer Genome Atlas (TCGA). relationship between messenger RNA (mRNA) expression, copy number variation (CNVs), and mutations “Writers,” “Readers,” “Erasers,” prognosis, immune cell infiltration, genetic were analyzed. CNVs found thirteen regulators. As expected, gain amplification regulators...
Cholecystocolic fistula (CCF), a connection between the gallbladder and neighboring colon, is rare entity with little consensus as to optimal surgical management. Existing case reports have described both open laparoscopic repairs. We describe first reported of successful robotic repair CCF in 50-year-old woman diagnosed cholangitis 5 years prior surgery. The patient had longitudinal follow-up by single surgeon, allowing for early diagnosis repair. This also includes radiographic imaging...
The only possibility for cure in patients with colon adenocarcinoma (CAC) isolated liver metastases (ILM) is resection of both primary and metastatic tumors. Little known about the implication sequence which a colectomy hepatectomy are performed on outcomes. This study analyzes whether impacts clinical outcomes.The National Cancer Database was queried CAC cases hepatic from 2010-2015 exclusion extrahepatic metastases. We compared treated liver-first approach (LFA) to those colectomy-first or...
Arrest in the embryologic intestinal rotation around superior mesenteric artery prevents proper attachment and subjects gut to volvulus ischemia which may lead bowel resection. The length of non-viable resected has been shown by Teitelbaum et al. be an independent predictor survival patients with postoperative short syndrome (RR = 5.74, P .003). Non-occlusive (NOMI) is a feed-forward loop vasoconstriction that aggravates primary ischemic injury. It initially reversible process potential...
ABSTRACT A very rare case of cellular angiofibroma arising from the rectum in a 62-year-old man with normal colonoscopy 2 years earlier is reported. To our knowledge, this first such reported literature. The tumor was transanally excised clear margins, and patient had no postoperative complications. It key to accurately differentiate lesion other subepithelial rectal tumors more aggressive genital soft tissue because clinical management varies. We performed review records pathology as well...
Splenic pseudoaneurysms (SPA) are a rare but serious sequela of blunt traumatic injury to the spleen. Management adult splenic trauma is well-studied, however, in children, management much less well-defined.A 15 year-old male presented with severe abdominal pain acute onset after sustaining his left side while playing football. FAST was positive for free fluid abdomen. Initial abdomen CT demonstrated grade III/IV laceration moderate large hemoperitoneum no active extravasation or vessels...
Baratta, Vanessa M. M.D., M.H.S.; Kurbatov, Vadim Einarsdottir, Hulda M.D.; Reddy, Vikram Ph.D. M.B.A.; Longo, Walter E. Pantel, Haddon J. M.D. Author Information
Abstract Pancreatic cancer is the fourth leading cause of death in United States with only 7% diagnosed patients surviving 5 years. Most pancreatic are not surgical candidates due to advanced stage at diagnosis. Current systemic chemotherapies, while exposing adverse side effects treatment, have been very effective decreasing tumor burden primarily poor drug uptake resulting from dense stromal nature tumors. Poly(lactic-co-glycolic acid)-based (PLGA) microparticles (MPs) a promising tool for...
Introduction: A key limitation of systemic delivery chemotherapy in pancreatic adenocarcinoma (PDAC) is poor drug penetrance to the tumor due surrounding desmoplastic reaction. Systemic side effects also interfere with treatment continuity. These can be circumvented a local method via endoscopic ultrasound (EUS) fine needle injection. Poly(lactic-co-glycolic acid) (PLGA) an FDA-approved polymer that utilized create spherical microparticles (MPs) containing encapsulated slowly eluted particle...
Abstract Pancreatic cyst detection rate has increased due to the widespread use of cross-sectional imaging. cysts can be divided pathologically into pseudocysts, non-neoplastic such as serous cystadenomas, and pancreatic cystic neoplasms. Malignant potential is seen in neoplasms, particularly mucinous neoplasms intraductal papillary Proper identification warrants either continual surveillance or evaluation for surgical resection prevent development adenocarcinoma. Large urban medical...