A5103123944- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Crystallization and Solubility Studies
- RNA modifications and cancer
- X-ray Diffraction in Crystallography
- Lung Cancer Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Preterm Birth and Chorioamnionitis
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Children's Physical and Motor Development
- Cancer-related Molecular Pathways
- Molecular Sensors and Ion Detection
- Phytase and its Applications
- Endoplasmic Reticulum Stress and Disease
- Liver Disease Diagnosis and Treatment
- Cardiovascular Effects of Exercise
Fudan University
2025
Yancheng Teachers University
2024
Guangdong Provincial Hospital of Traditional Chinese Medicine
2012-2023
Guangzhou University of Chinese Medicine
2017-2023
Shenzhen Pingle Orthopedic Hospital
2023
Hunan Cancer Hospital
2023
Taizhou University
2023
Tianjin Fourth Central Hospital
2019-2022
Tianjin Medical University
2021
Nankai University
2021
This study aimed to assess the clinical characteristics affecting outcomes after immune checkpoint inhibitors (ICI) therapies in non-small cell lung cancer (NSCLC) patients, and underlying mechanism tumor micro-environment (TIME).A total of 144 patients treated with ICI-based strategies were retrospectively analyzed. Expression 10 antibodies tissues from other 60 untreated NSCLC sequentially tested using multiplexed immunofluorescence (mIF) staining method. Correlation ICI treatment TIME...
Signal transducer and activator of transcription 3 (STAT3) is involved in the tumor growth metastasis human head neck squamous cell carcinoma (HNSCC) therefore a target with therapeutic potential. In this study, we show that HJC0152, recently developed anticancer agent STAT3 signaling inhibitor, exhibits promising antitumor effects against HNSCC both vitro vivo via inactivating downstream miR-21/β-catenin axis. HJC0152 treatment efficiently suppressed proliferation, arrested cycle at G0-G1...
During adolescence, research concerning physical fitness and brain development has become a focal point in health neuroscience. Academic debates on the precise impact of different sports skills adolescent lack consensus. While exercise's positive effects children older adults are well-documented, its specific adolescents remains unexplored. A year-long trial explores how diverse affect adolescents' development. The study dual focus: first, to examine potential correlation between acquisition...
Traditional Chinese Medicine (TCM) therapies should be tailored according to the different syndrome types. In order identify relationship between TCM Yin-cold (YC) or Yang-heat (YH) types and EGFR gene status, we prospectively studied 310 NSCLC patients. YH YC was diagnosed by three experts. symptoms signs were entered into a binary cluster analysis. The relationships types, classification analysis analyzed using chi-square test multivariate logistic regression. 299 patients who had their...
The present study aimed to determine the diagnostic concordance of plasma epidermal growth factor receptor (EGFR) mutation using droplet digital polymerase chain reaction (ddPCR) with tumor tissue samples and predictive clinical significance EGFR concentration. Plasma DNA from patients non-small cell lung cancer (NSCLC) were analyzed for exon 21 codon 858 (L858R) mutation, deletion 19 (ex19del) 20 790 (T790M) ddPCR. Firstly, mutations in compared matched concordance. Secondly, image...
A tumor occurs because of abnormal cell multiplication caused by many variables like a significant disturbance in the regulation growth and instability chromosome mitosis. Budding uninhibited benzimidazoles 1 (BUB1), BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B), budding 3 (BUB3) are key regulators mitosis, their expression is highly correlated with breast cancer (BrCa), sarcoma, hepatic carcinoma, other malignant tumors. However, occurrence BUBs (BUB1, BUB1B, BUB3) development...
// Yan-juan Zhu 1 , Hai-bo Zhang Yi-hong Liu Fu-li Ya-zhen 2 Yong Li Jian-ping Bai Li-rong Yan-chun Qu Xin Xian Chen Yan Guang-juan Zheng Oncology Department, The Second Affiliated Hospital of Guangzhou University Chinese Medicine, Guangdong Provincial China Pathology Correspondence to: Zhang, email: haibozh@aliyun.com Keywords: droplet digital polymerase chain reaction, epidermal growth factor receptor, non-small cell lung cancer, blood biopsy Received: October 25, 2016 Accepted: December...
// Yihao Yang 1, * , Ya Zhang Xin Qu Junfeng Xia 1 Dongqi Li Xiaojuan Yu Wang Zewei He Su Yonghong Zhou Lin Xie Zuozhang Bone and Soft Tissue Tumors Research Center of Yunnan Province, Department Orthopaedics, The Third Affiliated Hospital Kunming Medical University (Tumor Province), Kunming, 650118, China These authors contributed equally to this work co-first Correspondence to: Yang, email: yangzuozhang@163.com zuozhangyang1326@sohu.com Xie, xielinyanghan@163.com Keywords: differentially...
A new type of phenoxazine-based macrocyclic arene, calix[n]phenoxazines, are reported. Structurally diversified calix[3]phenoxazines with different substitutes on nitrogen atoms and methylene bridges synthesized a yield 30%-70%. Single crystal structure density function theory calculation show possess electron-rich cavities, which can selectively encapsulate suitable electron-deficient guests through multiple noncovalent interactions.
There occurs huge heterogeneity in clinical outcomes for patients with epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC) treated EGFR tyrosine kinase inhibitors (EGFR-TKIs). The purpose of this study was to indicate genetic biomarkers predicting primary resistance EGFR-TKIs these patients.Using a next-generation sequencing panel 168 cancer-related genes, matched tumor biopsy and plasma samples before treatments from NSCLC were analyzed. Patients taking...
Progress in the treatment options for small cell lung cancer (SCLC) remains poor. Concerns exist regarding efficacy of bevacizumab SCLC. The present study aimed to evaluate extensive stage (ES)-SCLC. A meta-analysis on studies conducted and listed Medline, Cochrane Trials, ASCO, ESMO ClinicalTrial databases, Chinese databases prior April 2015 was performed. All clinical trials which patients with ES-SCLC were treated considered. Survival rates at specific time points extracted from reported...
Although the incidence of thyroid carcinoma has increased over past several decades, it an excellent prognosis and overall 5-year survival, with a stable mortality rate, except in cases advanced stages or rare malignant tumor types. Biomarkers have emerged as effective targets molecular therapy against due to their rapid convenient detection; however, there been little clinical application. Macrophage stimulating 2 (Mst2) is proapoptotic protein implications carcinogenesis metastasis. We...
Abstract Background: It is meaningful to identify the potential clinical prognosis-associated oncogenes for cases with breast cancer, considering complicated pathogenesis of cancer.Methods: We first utilized bioinformatics approach investigate role DAPL1 (death-associated protein-like 1) in based on available datasets TCGA and GEO.Results: lowly expressed cancer tissues compared normal tissues. For TCGA-BRCA cohort, we observed a correlation between gene poor prognosis overall survival ( P...
Nasopharyngeal carcinoma has a good prognosis with intensity-modulated radiotherapy (IMRT) but recurrence occurs in 8–10% of patients, mostly the form distant metastases. Current systemic treatments for relapsed/metastatic (R/M) nasopharyngeal are limited, resulting poor overall survival rates. Immune checkpoint inhibitors have shown some activity, their small sample size and lack data limit effectiveness. This study reports patient R/M who had durable response to salvage therapy...
Some studies investigated the association between highly up-regulated in liver cancer (HULC) and overall survival (OS) of cancer. However, results were conflicted inconclusive. Therefore, we performed this meta-analysis to determine HULC OS A comprehensive online search was conducted on Online electronic databases (PubMed, EMBASE, Wanfang database) from earliest date Aug 30, 2016. The strength calculated with HRs respective 95% CIs. expression significantly associated cancers (HR = 2.12; CI...
e23063 Background: To determine the clinical significance of plasma EGFR mutation by droplet digital PCR (ddPCR). Methods: Plasma DNA from 103 consecutive NSCLC patients, including 54 with mutated and 49 wild in tumor tissues, were tested for L858R, exon 19 deletion (ex19del) T790M ddPCR. The was compared matched tumors to concordance. Second, we analyzed correlation mutant concentrations burden prognosis patients taking EGFR-TKIs. Results: sensitivity specificity ddPCR 72.22% (26/36) 98.51%...
Purpose The Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR-TKIs) have been used as first line treatment in advanced Non-Small Cell Lung Cancer (NSCLC) with sensitive EGFR gene mutations. In clinical practice, we found that the rate of mutation patients Yin-cold syndrome type traditional Chinese medicine (TCM) theory was higher than those Yang-heat syndrome. purpose this study to identify relationship between TCM and status well efficacy EGFR-TKIs NSCLC patients. Methods...
Cuproptosis is a novel discovered mode of programmed cell death. To identify the molecular regulatory patterns related to cuproptosis, this study explored correlation between cuproptosis-related genes (CRGs) and prognosis, metabolism, treatment hepatocellular carcinoma (HCC). We collected 363 HCC samples from Cancer Genome Atlas (TCGA) database classified them into 2 clusters based on expression genes. Survival analysis revealed that Cluster 1 had better overall survival (OS), functional...
e15558 Background: The standard third-line treatment for mCRC is regorafenib, fruquintinib or TAS-102. However, the efficacy was not satisfied. Since VEGF and EGFR share downstream signaling pathway, targeting these two pathways may have synergistic efficacy. phase Ib trial with regorafenib combined cetuximab shown preliminary benefit. Fruquintinib a small molecule highly selective VEGFR1/2/3 inhibitor. Here, we evaluate safety of plus in previously treated RAS/BRAF wild-type mCRC. Methods:...
Abstract Background : Thyroid cancer (THCA) has gradually become the highest incidence of endocrine tumors, but its immunotherapy is still in infancy. Cuproptosis been reported to be closely related various tumors. However, mechanism cuproptosis THCA remains obscure. Methods TCGA-THCA dataset was downloaded from TCGA GDC portal. We then conducted survival analysis based on scores (CPs), and constructed models RF LASSO. GSVA ssGSEA subsequently performed. CIBERSORT used assess immune...