A5100421292- Connective tissue disorders research
- Cardiac and Coronary Surgery Techniques
- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Urban Transport and Accessibility
- Mechanical Circulatory Support Devices
- Urban Green Space and Health
- Galectins and Cancer Biology
- Obesity, Physical Activity, Diet
- IL-33, ST2, and ILC Pathways
- Atherosclerosis and Cardiovascular Diseases
- Dermatological and Skeletal Disorders
- Genetic Associations and Epidemiology
- RNA regulation and disease
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- Sex and Gender in Healthcare
- Cell death mechanisms and regulation
- Protein Degradation and Inhibitors
- Cardiac Structural Anomalies and Repair
- Yersinia bacterium, plague, ectoparasites research
Beijing Anzhen Hospital
2013-2024
Capital Medical University
2013-2024
Fu Wai Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Nanjing Drum Tower Hospital
2023
National Natural Science Foundation of China
2023
Creative Commons
2023
Zhongshan Hospital
2021
Fudan University
2021
Ministry of Education of the People's Republic of China
2011-2020
Rationale: Thoracic aortic aneurysm (TAA) leads to substantial mortality worldwide. Familial and syndromic TAAs are highly correlated with genetics. However, the incidence of sporadic isolated TAA (iTAA) is much higher, genetic contribution not yet clear. Objective: Here, we examined characteristics iTAA. Methods Results: We performed a screen 551 iTAA cases 1071 controls via whole-exome sequencing. The prevalence pathogenic mutations in known causal genes was 5.08% cohort. selected 100...
ABSTRACT Yersinia enterocolitica is a heterogeneous bacterial species with wide range of animal reservoirs through which human intestinal illness can be facilitated. In contrast to the epidemiological pattern observed in United States, infections China present similar those European countries and Japan, wherein “Old World” strains (biotypes 2 5) are prevalent. To gain insights into evolution Y. pathogenic properties toward hosts, we sequenced genome biotype 3 strain, 105.5R(r) (O:9),...
Despite increased literature focusing on the role of built environment (BE) in health, few cohort studies have quantitatively analyzed neighborhood walkability relation to risk death and cardiovascular disease (CVD). This longitudinal study aimed at evaluating association between perceived BE attributeswith mortality major CVD based Prospective Urban Rural Epidemiology China (PURE-China).
Genetic contribution to coronary artery disease (CAD) remains largely unillustrated. Although transcriptomic profiles have identified dozens of genes that are differentially expressed in normal and atherosclerotic vessels, whether those genetically associated with CAD be determined. Here, we combined genetic association studies, transcriptome vitro vivo functional experiments identify novel susceptibility for CAD.
Palmd-deficient mice of advanced age manifest increased aortic valve peak velocity, thickened leaflets, and excessive extracellular matrix deposition, which are key features calcific disease. PALMD is predominantly expressed in endothelial cells valves, PALMD-silenced valvular prone to oscillatory shear stress-induced endothelial-to-mesenchymal transition. Mechanistically, associated with TNFAIP3 interaction protein 1, a binding IKBKG NF-κB signaling. Loss impairs TNFAIP3-dependent...
Bacterial populations in clinical and laboratory settings contain a significant proportion of mutants with elevated mutation rates (mutators). Mutators have particular advantage when multiple beneficial mutations are needed for fitness, as antibiotic resistance. Nevertheless, high potentially lead to increasing numbers deleterious subsequently the decreased fitness mutators. To test how changed accumulation, genome sequencing assays nine Escherichia coli mutY mutators were undertaken an...
Background: Debate on treatment for young patients with coronary artery disease still exists. This study aimed to investigate the intermediate- and long-term outcomes between bypass grafting (CABG) percutaneous intervention (PCI) in aged 18–45 years diabetes mellitus (DM). Methods: Between January 2006 March 2016, a total of 2018 DM including 517 cases CABG 1501 PCI were enrolled study. Using propensity score matching (PSM), 406 matched from each group. The data collected. primary end point...
Abstract Following hospital discharge, patients with type A acute aortic dissection (TA-AAD) may present an increase in mortality risk. However, little is known about specific biomarkers associated post-discharge survival, and there a paucity of prognostic markers TA-AAD. Here, we identify nine candidate proteins for patietns TA-AAD cross-sectional dataset by unbiased protein screening in-depth bioinformatic analyses. In addition, explore their association short-term long-term derivation...
To compare the long-term outcomes of coronary artery bypass grafting (CABG) vs. percutaneous intervention (PCI) with drug-eluting stents (DESs) for disease (CAD) patients chronic kidney (CKD).Coronary decreased function (estimated glomerular filtration rate <60 ml/min/1.73 m2) who underwent CABG (n = 533) or PCI DES 952) from 2013 to 2020 were enrolled at a single center. The baseline characteristics and clinical compared between groups each matched pair CKD. primary endpoint was occurrence...
Objective The clinical implication of coronary tortuosity is unclear. present study was conducted to determine the relationships between and high-sensitivity C-reactive protein (hs-CRP) concentration cerebrovascular accident in hypertensive patients without artery disease. Methods In total, 236 with normal angiography findings were categorized into 3 different groups: control participants (n = 58), who had neither hypertension nor tortuosity; but no (H-NCT group, n 93); both (H-CT 85)....
In the mid-1990s, Swedish expert team proposed saphenous vein graft (SVG) harvesting with pedicle tissue. The short-term and long-term patency rates of great obtained by no-touch (NT) were higher than those conventional (CON). past, NT was mainly used in on-pump coronary artery bypass grafting (CABG), grafts mostly single grafts. this study, we retrospectively analyzed safety effectiveness sequential using off-pump CABG.From 2017 to 2019, a total 505 patients included study. There 150 group...
Objectives Aims to compare the contemporary and long-term outcomes of coronary artery bypass grafting (CABG) percutaneous intervention (PCI) in disease (CAD) patients with advanced chronic kidney (CKD). Methods 823 CAD CKD (eGFR &lt; 30 ml/min/1.73 m 2 ) were collected, including 247 who underwent CABG 576 received PCI from January 2014 February 2021. The primary endpoint was all-cause death. secondary endpoints included major adverse cardiac cerebrovascular events (MACCEs), myocardial...
Study Design. A genetic case-control study. Objective. To replicate recently reported loci associated with adolescent idiopathic scoliosis (AIS) in the Chinese Han population, and to determine relationship between gene expression clinical features of patients. Summary Background Data. recent study conducted Japanese population identified several novel susceptible loci, which might provide new insights into etiology AIS. However, association these genes AIS other populations remains unclear....
Objective: To discuss the clinical safety and efficacy about off-pump coronary artery bypass grafting (OPCABG) in octogenarians. Methods: From June 2005 to July 2014, 252 patients (male 208, female 44, with a mean age of 81.7 years old) underwent OPCABG Beijing Anzhen Hospital who were aged 80 or older enrolled. Results: Eight (3.2%) diagnosed as single vessel disease (CAD), 29 cases (11.5%) bifurcation CAD, 215 (85.3%) multivessel CAD. One hundred one (40.1%) left main disease, among which...
Background: Calcific aortic valve disease (CAVD) is characterized by fibrocalcific remodeling. Single nucleotide polymorphisms in the palmdelphin (PALMD) locus that result reduced PALMD expression are strong risk factors for CAVD development.Objectives: To identify whether a causative driver and explore mechanism which decreased contributes to CAVD.Methods: Palmd knockout (Palmd-/-) Palmd/Apoe double (DKO) mice were generated detect function pathology of valves advanced age groups. RNA...
Objective To identify new susceptibility genes for coronary artery disease(CAD)by integrating genome wide association study and gene expression profiling. Methods On account of our data study(GWAS)on CAD, integrative analysis profiles GWAS CAD was conducted, we obtained candidate single nucleotide polymorphisms(SNPs)for a multicenter case-control genetic study.Using DNA ligase chain reaction-based genotyping method, validated these loci in two independent...
Objective To analyze the safety and efficacy of laparoscopic radical resection colorectal cancer for elderly patients over 70 years old. Methods From January 2014 to 2017, a retrospective analysis with surgery in Department General Surgery, Beijing Anzhen Hospital, Capital Medical University was performed.According patient′s age, were divided into ≥70 old group (68 cases) and<70 (84 cases). The preoperative clinical data two groups analyzed.The surgeons strictly followed standard...
Abstract Background: Coronary artery bypass grafting (CABG) materials comprise the combination of left internal mammary and saphenous vein. The patency rate vein grafts is considered not ideal; more studies support that no-touch (NT) procedure can improve grafts. However, it clear NT technology used in sequential during off-pump coronary surgery. This study explored whether technique safety efficacy compared to conventional manner surgery using graft. Methods: was a prospective single-center...
Shi, Bo MD; Benlong Liu, Dun Li, Yang Xia, Sanqiang Sun, Xu Zhen Qian, Bangping Zhu, Zezhang Qiu, Yong MD