A5073810052- Effects and risks of endocrine disrupting chemicals
- Per- and polyfluoroalkyl substances research
- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Birth, Development, and Health
- Health, Environment, Cognitive Aging
- Environmental Justice and Health Disparities
- Genetically Modified Organisms Research
- Environmental Toxicology and Ecotoxicology
- Genetics, Aging, and Longevity in Model Organisms
- Ethics in Clinical Research
- Heavy metals in environment
- Atmospheric Ozone and Climate
- Vitamin D Research Studies
- Cancer Risks and Factors
- Atmospheric chemistry and aerosols
- Contact Dermatitis and Allergies
- Gestational Diabetes Research and Management
- Climate Change and Health Impacts
- Trace Elements in Health
- Indoor Air Quality and Microbial Exposure
- Chemical Safety and Risk Management
- Nanoparticles: synthesis and applications
- Risk Perception and Management
Northeastern University
2022-2025
Universidad del Noreste
2021-2024
University of California, San Francisco
2018-2021
California Department of Toxic Substances Control
2019-2020
University of Tennessee Health Science Center
2019-2020
University of California, Berkeley
2006-2020
Berkeley Public Health Division
2018-2019
Cancer Prevention Institute of California
2012
U.S. Army Engineer Research and Development Center
2006-2009
United States Army
2006-2009
While research and regulatory attention to per- polyfluoroalkyl substances (PFAS) has increased exponentially in recent years, data are uneven incomplete about the scale, scope, severity of PFAS releases resulting contamination United States. This paper argues that absence high-quality testing data, can be presumed around three types facilities: (1) fluorinated aqueous film-forming foam (AFFF) discharge sites, (2) certain industrial facilities, (3) sites related PFAS-containing waste. on all...
Abstract Purpose of Review The discovery per- and polyfluoroalkyl substances (PFAS) in the environment humans worldwide has ignited scientific research, government inquiry, public concern over numerous adverse health effects associated with PFAS exposure. In this review, we discuss use immunotoxicity data regulatory clinical decision-making contexts question whether recent efforts adequately account for decision-making. Recent Findings Government academic reviews confirm strongest human...
Introduction: This study investigates associations between fine particulate air pollution (PM2.5) exposure and thyroid hormone levels during pregnancy in Puerto Rican individuals, a vulnerable population facing socioeconomic environmental disparities. Methods: research draws on data from the PROTECT cohort involves 1040 participants to measure effect of PM2.5 developmentally important hormones (TSH, T3, T4, FT4). Pollution concentrations were linked participant locations using EPA quality...
Toxicogenomics has provided innovative approaches to chemical screening, risk assessment, and predictive toxicology. If applied ecotoxicology, genomics tools could greatly enhance the ability understand modes of toxicity in environmentally relevant organisms. Daphnia magna, a small aquatic crustacean, is considered "keystone" species ecological food webs an indicator for toxicant exposure. Our objective was demonstrate potential utility gene expression profiling ecotoxicology by identifying...
PFAS (per-and polyfluoroalkyl substances) are a large class of synthetic chemicals widely used in consumer products and industrial processes. The scientific literature on has increased dramatically the last decade. Many stakeholders, including regulators, scientists, non-governmental organizations, concerned individuals could benefit from an efficient way to access health toxicological related PFAS. To create systematic evidence map available peer-reviewed or research for 29 A protocol...
Abstract The manufacture and production of industrial chemicals continues to increase, with hundreds thousands chemical mixtures used worldwide, leading widespread population exposures resultant health impacts. Low-wealth communities color often bear disproportionate burdens exposure impact; all compounded by regulatory delays the detriment public health. Multiple authoritative bodies scientific consensus groups have called for actions prevent harmful via improved policy approaches. We...
Ecotoxicogenomic approaches to environmental monitoring provide holistic information, offer insight into modes of action, and help assess the causal agents potential toxicity effluents beyond traditional end points death reproduction. Recent investigations toxicant exposure indicate dose-dependent changes are a key issue in interpreting genomic studies. Additionally, there is interest developing methods integrate gene expression studies regulation, No Observed Transcriptional Effect Level...
Phthalates are ubiquitous chemicals linked to hormonal disruptions that affect reproduction and development. Multiple antiandrogenic phthalates exposure during fetal development can have greater impacts than individual exposure; thus, the National Academy of Sciences (NAS) recommends them for cumulative assessment. Using Health Nutrition Examination Survey data (NHANES, 2001–2012), we developed a potency-weighted sum daily intake (∑androgen-disruptor; μg/kg/day) di-n-butyl phthalate (DnBP),...
Reproduction is a functional outcome that relies on complex cellular, tissue, and organ interactions span the developmental period to adulthood. Thus, assessment of its disruption by environmental chemicals would benefit significantly from scalable innovative approaches testing using functionally comparable reproductive models such as nematode C. elegans. We adapted previously described low-throughput in vivo chromosome segregation assay elegans predictive toxicity leveraged available public...
Abstract Prenatal polybrominated diphenyl ether (PBDE) exposures are a public health concern due to their persistence and potential for reproductive developmental harm. However, we have little information about the extent of fetal during critical periods variation in groups that may be more highly exposed, such as communities color lower socioeconomic status (SES). To characterize maternal–fetal PBDE among potentially vulnerable groups, levels were examined largest sample matched maternal...
Abstract Perfluoroalkyl and polyfluoroalkyl substances (PFASs) organophosphate flame retardants (OPFRs) are chemicals that may contribute to placenta-mediated complications adverse maternal-fetal health risks. Few studies have investigated these in relation biomarkers of effect during pregnancy. We measured 12 PFASs four urinary OPFR metabolites 132 healthy pregnant women mid-gestation examined a subset with placental development disease (n = 62). Molecular included integrin alpha-1 (ITGA1),...
Infertility affects ∼12 % of couples, with environmental chemical exposure as a potential contributor. Of the chemicals that are actively manufactured, very few assessed for reproductive health effects. Rodents commonly used to evaluate effects, which is both costly and time consuming. Thus, there pressing need rapid methods test broader range chemicals. Here, we developed strategy large numbers toxicity via yeast, S. cerevisiae high-throughput assay assess gametogenesis new approach method...
Ecotoxicogenomic approaches are emerging as alternative methods in environmental monitoring because they allow insight into pollutant modes of action and help assess the causal agents potential toxicity beyond traditional end points death, growth, reproduction. Gene expression analysis has shown particular promise for identifying gene biomarkers chemical exposure that can be further used to monitor specific exposures environment. We focused on development markers detect discriminate between...
Abstract Background Nail salons represent a rapidly growing industry with mainly Vietnamese immigrant workers. Workers routinely handle nail products containing hazardous compounds, yet have limited accessible information to minimize workplace exposures. Methods We conducted culturally appropriate pilot intervention on chemical exposure reduction strategies. trained eight owners, who then workers in their salons. pre‐, mid‐, and post‐intervention assessments workers, including an in‐person...
Phenols and parabens are two classes of high production volume chemicals that used widely in consumer personal care products have been associated with reproductive harm pregnancy complications, such as preeclampsia gestational diabetes. However, studies examining their influence on maternal blood pressure hypertension limited.
Many California nail salon workers are low-income Vietnamese women of reproductive age who use products daily that contain androgen-disrupting phthalates, which may increase risk male tract abnormalities during pregnancy. Yet, few studies have characterized phthalate exposures among this workforce. To characterize individual metabolites and cumulative phthalates exposure a potentially vulnerable occupational group workers, we collected 17 post-shift urine samples from at six San Francisco...
Polybrominated diphenyl ether (PBDE) exposures have been associated with adverse pregnancy outcomes. A hypothesized mechanism is via alterations in placental development and function. However, we lack biomarkers that can be used as early indicators of maternal/fetal response to PBDE and/or perturbations or