A5053510793- Hepatitis C virus research
- Hepatitis B Virus Studies
- Vaccine Coverage and Hesitancy
- Liver Disease Diagnosis and Treatment
- Virology and Viral Diseases
- Parvovirus B19 Infection Studies
- Cytomegalovirus and herpesvirus research
- SARS-CoV-2 and COVID-19 Research
- Sleep and related disorders
- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- COVID-19 Pandemic Impacts
- Viral Infections and Vectors
- Syphilis Diagnosis and Treatment
- COVID-19 and Mental Health
- Surgical site infection prevention
- Urinary Tract Infections Management
- Herpesvirus Infections and Treatments
- COVID-19 Clinical Research Studies
- Pediatric Urology and Nephrology Studies
- Mosquito-borne diseases and control
- Antimicrobial agents and applications
- Medical Device Sterilization and Disinfection
- COVID-19 Impact on Reproduction
- Respiratory viral infections research
Catholic University of Health and Allied Sciences
2021-2025
University of Würzburg
2023
In low-income countries, the empirical treatment of urinary tract infections (UTIs) without laboratory confirmation is very common, especially in primary health facilities. This scenario often leads to unnecessary and ineffective antibiotic prescriptions, prompting emergence spread antimicrobial resistance. We conducted this study examine antibiogram uropathogens causing community-acquired among outpatients attending selected facilities Tanzania. Method: was a cross-sectional centre-based...
The vaccination rate against COVID-19 remains low in developing countries due to vaccine hesitancy. Vaccine hesitancy is a public health threat curbing pandemic globally. Healthcare professionals have been found play critical role advocacy and promotion campaigns the general population. A cross sectional study was conducted initial months of roll out program Tanzania determine acceptance rate, perceived barriers, cues for actions. total 811 healthcare participated from 26 facilities western...
Abstract Background Globally, urinary tract infections (UTIs) are the leading cause of hospital visits, especially among women. In many developing countries, in lower health facilities, dipstick urinalysis is most commonly requested test, as urine culture not routinely performed. The test can potentially reduce number patients who could be treated with empirical antibiotics and burden antibiotic resistance. current study determined utility diagnosing UTIs using a gold standard method....
Hepatitis B virus genetic diversity (HBV) evaluation is scarcely done in Tanzania, imposing a crucial knowledge gap toward elimination of HBV infection by 2030. This cross-sectional study was conducted on purposively selected 21 plasma samples with high HBV-deoxyribonucleic acid (DNA) levels > 300,000IU/mL. DNA extraction using Qiagen Blood Mini Kit (Qiagen, Hilden, Germany). Partial amplification 423 bp pol gene, sequencing and analysis; statistical analysis STATA version 15 were done....
Surgical site infections (SSIs) after limb amputations have been associated with increased patient morbidity, mortality and costs. This study aimed to determine the incidence, bacteriological profile predictors of SSIs following amputation at Bugando Medical Centre (BMC) Sekou Toure Regional Referral Hospital (SRRH). The longitudinal was conducted among patients undergoing between March July 2024 BMC SRRH. Pre-tested structured questionnaires were used collect sociodemographic clinical data....
Antimicrobial resistance has persisted as a global threat with increasing associated numbers of morbidity and mortality. ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp.) were termed by the Infectious Diseases Society America group bacteria rapid antibiotic development. The aim study was to describe extent patterns pathogens isolated in pus swabs from patients admitted at Muhimbili National...
Introduction: Superficial skin fungal infections are among the neglected communicable diseases in many developing countries. Schoolchildren most affected groups Southern Tanzania. The main objective of this study was to determine magnitude and associated risk factors superficial primary schoolchildren Methods: A cross-sectional descriptive community-based conducted October 2017 a public school Songea Municipal, sample 500 pupils interviewed physical examination performed assess for presence...
To determine the prevalence of hepatitis B virus (HBV) infection, knowledge regarding HBV, vaccination status, and associated factors among household contacts HBV index cases in Mwanza, Tanzania.
The transmission of the SARS-CoV-2 virus, which causes COVID-19, has been documented worldwide. However, evidence extent to occurred in different countries is still be established. Understanding magnitude and distribution through seroprevalence studies important designing control preventive strategies communities. This study investigated seropositivity virus antibodies communities three districts Mwanza region, Tanzania. A household cross-sectional survey was conducted September 2021 using...
Background. Brucellosis is one of the most prevalent zoonotic neglected tropical diseases across globe. Brucella melitensis (B. melitensis), pathogenic species responsible for several pregnancy adverse outcomes in both humans and animals. Here, we present data on magnitude B. antibodies among pregnant women Mwanza, Tanzania, information that might be useful understanding epidemiology disease devising appropriate control interventions this region. Methodology. A hospital-based cross-sectional...
Abstract Background Pantoea agglomerans (P. agglomerans) is an environmental gram-negative bacterium that rarely infects humans. P. infections have never been reported in Tanzania. We investigated the occurrence of bloodstream among neonates Intensive Care Unit (NICU) and their subsequent clinical outcome occurred 2019. Methodology Blood samples were collected from with sepsis. A total 19 isolated 17 infected neonates; two had twice. 14 patient files retrieved medical records. Results The...
Background: Viral infections such as Human cytomegalovirus (HCMV), Rubella virus (RV) and Herpes simplex virus-2(HSV-2) are implicated in causing adverse pregnancy outcomes with limited data from Africa. Here we report the magnitude of these viruses among women unfavorable (WUP) Mwanza, Tanzania. Methods: A cross sectional study involving 198 WUP was conducted between March June 2019 Mwanza. Enzyme linked immunosorbent assay used to detect HCMV RV IgM IgG antibodies while...
Introduction: Gestational diabetes mellitus (GDM) is a potential risk factor for both maternal and foetal complications during pregnancy. This study aimed to determine the prevalence factors associated with GDM among pregnant women in Southern Tanzania.Methods: A cross-sectional was conducted 612 randomly selected attending routine antenatal clinics Tanzania from September October 2017. Detailed medical gynaecological history taken using pre-tested questionnaires. Blood samples were...
Abstract Sleep modulates the immune response and sleep loss can reduce immunogenicity of certain vaccinations. Vice versa responses impact sleep. We aimed to investigate influence mental health quality on COVID-19 vaccinations and, conversely, quality. The prospective CoVacSer study monitored health, quality, Anti-SARS-CoV-2-Spike IgG titres in a cohort 1,082 healthcare workers from 29 th September 2021 19 December 2022. Questionnaires blood samples were collected before, 14 days, three...
Sleep modulates the immune response, and sleep loss can reduce vaccine immunogenicity; vice versa, responses impact sleep. We aimed to investigate influence of mental health quality on immunogenicity COVID-19 vaccinations and, conversely, quality. The prospective CoVacSer study monitored health, Anti-SARS-CoV-2-Spike IgG titres in a cohort 1082 healthcare workers from 29 September 2021 19 December 2022. Questionnaires blood samples were collected before, 14 days, 3 months after third...
Contaminated-hospital surfaces are an important source of pathogenic bacteria causing health-care associated infection (HCAIs). Monitoring the performance disinfectants that routinely used to clean hospital is critical for prevention and control HCAIs. Nevertheless, evaluation their efficacy not practiced in most resource-limited countries. This study was designed determine sodium dichloroisocyanurate (NaDCC) chloroxylenol against American Type Culture Collection (ATCC) respective multidrug...
COVID-19 vaccination remains to be the most important intervention in fight against pandemic. The immunity among vaccinated population and its durability can significantly vary due various factors. This study investigated humoral immune responses individuals who received any of vaccines approved for use Tanzania. A total 1048 randomly selected adults at different time points were enrolled (IR) tested baseline three months later (960, 91.6%). level SARS-CoV-2 anti-spike/receptor binding...
Increasing antimicrobial resistance (AMR) colonizing domesticated animals is a global concern threatening food safety. This study aimed at determining the prevalence of multidrug (MDR) and epidemiological cut-off values (ECVs) E. coli isolated from poultry pigs in Mwanza, Tanzania. cross-sectional was conducted between June August 2021, involving 297 pigs, 191 broilers, 203 layers. Rectal cloacal swabs were collected processed following standard guidelines. ECVs determined using normalized...
This study was designed to determine the prevalence and co-infection of Mycobacterium tuberculosis other pathogenic bacteria among presumptive cases (TB) at selected hospitals in Mwanza, Tanzania. GeneXpert conventional bacteriological culture sensitivity were used for detection TB bacteria, respectively. STATA version 13.0 data analysis. The median (IQR) age participants 33 (19–51) years with males forming more than half (i.e., 59% (158/264)) participants. Microscopically, 29.5% (78/264)...
Rubella virus (RV) infection in susceptible women during the first trimester of pregnancy is associated with congenital syndrome (CRS). In countries where a vaccination program implemented, active case surveillance emphasized. This report documents magnitude cases before and after vaccine implementation Tanzania. A total 8750 children adolescents signs symptoms RV were tested for IgM antibodies between 2013 2019 using enzyme immunoassay followed by descriptive analysis. The median age...
Leptospirosis is a zoonotic neglected tropical disease with worldwide distribution caused by the pathogenic spirochetes of genus Leptospira. Despite being widespread in regions, it has never been considered routine diagnostic panel for febrile patients. This study determined seropositivity and factors associated Leptospira antibodies among adult patients Mwanza, Tanzania. The cross-sectional involving 296 attending different outpatient clinics Mwanza region was conducted between May July...
Mumps is an acute contagious viral disease caused by paramyxovirus characterized complications that include orchitis, oophoritis, aseptic meningitis, and spontaneous abortion among many others. This study reports high mumps IgG seropositivity school-aged children in rural areas of the Mbeya region, information might be useful understanding epidemiology instituting appropriate control measures including vaccination. Between May July 2023, a cross-sectional involving 196 enrolled aged 5–13...
Chronic hepatitis B virus (HBV) infection is still a major public health problem. In response to the World Health Organization (WHO), Tanzania implemented immunization and treatment achieve eradication of HBV by 2030. To this goal, frequent updates demographic data, antiviral therapy eligibility, uptake are essential. We therefore evaluated among chronically HBV-infected patients attending at Bugando Medical Centre (BMC), Tanzania.
<title>Abstract</title> Background Frequent evaluation and understanding of the genetic diversity HBV virus in different affected global settings is essential towards elimination infection by 2030. In this regard, scarcely done Tanzania, imposing a crucial knowledge gap. We serologically genetically characterized from 21 chronically HBV-infected patients attending Bugando Medical Centre to determine diversity. Methods This cross-sectional study was conducted on selected plasma samples with...
Background: Hepatitis B virus is a significant public health concern, especially among high-risk groups such as diabetic patients. infection can lead to serious liver diseases hepatocellular carcinoma and cirrhosis. Precise data on the prevalence of infections in these are crucial for executing targeted interventions aimed at reducing transmission. Here, we report factors associated with patients Mwanza, Tanzania. Methodology: A cross-sectional study involving 177 was conducted between May...