Abstract Background Surgical site infection (SSI) is the second most common infectious complication after urinary tract following a delivery by caesarean section (CS). At Bugando Medical Centre there has no study documenting epidemiology of SSI CS despite large number CSs performed and relatively occurrence SSIs. Methods This was prospective cohort involving pregnant women who underwent between October 2011 February 2012 at Centre. A total 345 were enrolled. Preoperative, intraoperative...

Antimicrobial resistance is fast becoming a global concern with rapid increases in multidrug-resistant Gram negative organisms. The prevalence of extended spectrum beta-lactamase (ESBL)-producing clinical isolates the burden on implementing infectious disease management low socio-economic regions. As incidence can vary widely between regions, this study was done to determine patterns Gram-negative organisms at Bugando Medical Center, tertiary hospital Mwanza, Tanzania.A total 800 samples...

Typhoid intestinal perforation is still prevalent in many developing countries. Despite the advances management, outcome these patients resource limited countries very poor. This study was to review our experiences on surgical management of typhoid and determine prognostic factors for mortality local setting.This a combined retrospective prospective who were operated at Bugando Medical Centre between August 2006 September 2011. Data collected analyzed using SPSS computer software version...

The increased presence of extended-spectrum beta-lactamase (ESBL)-producing bacteria in humans, animals, and their surrounding environments is global concern. Currently there limited information on ESBL rural farming communities worldwide. We performed a cross-sectional study Mwanza, Tanzania, involving 600 companion domestic farm animals between August/September 2014. Rectal swab/cloaca specimens were processed to identify ESBL-producing Enterobacteriaceae. detected 130 (21.7%) carrying...

The study was conducted to establish predictors of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) neonatal sepsis and mortality in a tertiary hospital, Tanzania. Between July December 2016, blood culture performed neonates with clinical features neonates/mothers/guardians were screened for ESBL colonization. Selected isolates underwent whole genome sequencing investigate relatedness. Logistic regression analysis determine ESBL-PE associated mortality. Neonatal...

Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae commonly cause infections worldwide. BlaCTX-M-15 has been detected in hospital isolates Mwanza, Tanzania. Little is known regarding the faecal carriage of ESBL and blaCTX-M-15 allele among humans community developing countries. A cross-sectional study involving 334 from settings Mwanza City was conducted between June September 2014. Stool specimens were collected processed to detect producing enterobacteriaceae. confirmed...

A total of 17 Enterobacter-like isolates were obtained from blood during a septicaemia outbreak in neonatal unit, Tanzania, that could not be assigned based on phenotypic test to any existing Enterobacter species. Eight representative investigated detail. Fermentation characteristics, biochemical assays and fatty acid profiles for taxonomic analysis determined supplemented with information derived whole genome sequences. Phenotypic morphological tests revealed these Gram-stain-negative,...

In low-income countries, the empirical treatment of urinary tract infections (UTIs) without laboratory confirmation is very common, especially in primary health facilities. This scenario often leads to unnecessary and ineffective antibiotic prescriptions, prompting emergence spread antimicrobial resistance. We conducted this study examine antibiogram uropathogens causing community-acquired among outpatients attending selected facilities Tanzania. Method: was a cross-sectional centre-based...

Despite the available cost effective antenatal testing and treatment, syphilis human immunodeficiency virus (HIV) are still among common infections affecting pregnant women especially in developing countries. In Tanzania, tested only once for HIV during clinic (ANC) visits. Therefore, there missed opportunities screening those who were not ANC visits acquiring course of pregnancy. This study was designed to determine seroprevalence at delivery seroconversion rate delivering Bugando Medical...

Abstract Background Sero-positivity rates of the rubella virus among pregnant women vary widely throughout world. In Tanzania, vaccination is not included in national immunization schedule and there therefore no antenatal screening for this viral disease. So far, are reports on sero-prevalence Tanzania. As a result, study was undertaken to establish sero-positivity rate risk factors attending care clinics Mwanza, Methods From November 2012 May 2013 total 350 were enrolled their serum samples...

Brucellosis and leptospirosis are among neglected tropical zoonotic diseases particularly in the resource limited countries. Despite being endemic these countries, there is paucity of information on its magnitude. This study investigated seropositivity Brucella spp. Leptospira spp., associated factors abattoir workers meat vendors city Mwanza, Tanzania.A community based cross-sectional was conducted Mwanza from May to July 2017. Socio-demographic other relevant were collected. Detection...

The vaccination rate against COVID-19 remains low in developing countries due to vaccine hesitancy. Vaccine hesitancy is a public health threat curbing pandemic globally. Healthcare professionals have been found play critical role advocacy and promotion campaigns the general population. A cross sectional study was conducted initial months of roll out program Tanzania determine acceptance rate, perceived barriers, cues for actions. total 811 healthcare participated from 26 facilities western...

Bacterial resistance has increased in the AIDS era and is attributed to widespread use of cotrimoxazole prophylaxis against opportunistic infections HIV/AIDS patients. In Tanzania, been used for more than ten years. Little known, however, about its impact on spread antibiotic HIV positive This cross-sectional study was done compare magnitude bacterial other antimicrobials among isolates from infected patients those not non-HIV attending Bugando Medical Centre (BMC). Susceptibility testing...

Infections are common complications occurring in malnourished childrenas a result of impaired immunity. Urinary tract infections (UTI) have been found to be the commonest cause fever normal children developing countries. However, data regarding UTI among is limited because most time severe and moderately afebrile despite significant bacteriuria. A total 402 underfives were enrolled. Demographic other clinical characteristics collected using standardized collection tool. Urine specimens...

Background: Needle-stick injuries (NSIs) and splash exposures carry a risk of occupational acquisition HIV other blood borne pathogens to healthcare workers (HCWs) involved in clinical care. This study was carried out determine the frequency factors contributing NSIs as well post-exposure practices among HCWs our centre. Methods: cross-sectional which conducted at Bugando Medical Centre (BMC) over one-year period between April 2013 March 2014. Results: Out 436 who participated this study,...

Abstract Background Globally, urinary tract infections (UTIs) are the leading cause of hospital visits, especially among women. In many developing countries, in lower health facilities, dipstick urinalysis is most commonly requested test, as urine culture not routinely performed. The test can potentially reduce number patients who could be treated with empirical antibiotics and burden antibiotic resistance. current study determined utility diagnosing UTIs using a gold standard method....

Hepatitis B virus genetic diversity (HBV) evaluation is scarcely done in Tanzania, imposing a crucial knowledge gap toward elimination of HBV infection by 2030. This cross-sectional study was conducted on purposively selected 21 plasma samples with high HBV-deoxyribonucleic acid (DNA) levels > 300,000IU/mL. DNA extraction using Qiagen Blood Mini Kit (Qiagen, Hilden, Germany). Partial amplification 423 bp pol gene, sequencing and analysis; statistical analysis STATA version 15 were done....

Surgical site infections (SSIs) after limb amputations have been associated with increased patient morbidity, mortality and costs. This study aimed to determine the incidence, bacteriological profile predictors of SSIs following amputation at Bugando Medical Centre (BMC) Sekou Toure Regional Referral Hospital (SRRH). The longitudinal was conducted among patients undergoing between March July 2024 BMC SRRH. Pre-tested structured questionnaires were used collect sociodemographic clinical data....

Background: Hospitalised neonates are at increased risk of carrying extended-spectrum β-lactamase-producing Enterobacterales (ESBL-PE) and carbapenemase-producing (CPE), possibly leading to invasive infections. This study determined the faecal carriage ESBL-PE, CPE, associated factors among Muhimbili National Hospital (MNH). Methods: A hospital-based cross-sectional was conducted aged ≤ 28 days admitted MNH. The participants’ data rectal swab samples were collected. Samples processed detect...

Infections, trauma, malignances and poorly controlled diabetes are common causes of chronic lower limb ulcerations in developing countries. Infected wound with multi-drug resistant bacteria usually associated increased morbidity mortality. We report the distribution pathogens colonizing ulcers their drug susceptibility pattern from Bugando Medical Centre (BMC) a tertiary hospital Tanzania. Three hundred non-repetitive swabs were aseptically collected 300 patients using sterile processed...

Kaposi's Sarcoma is the most common sarcoma and second prevalent cancer seen in Tanzania. Little known about our setting as there paucity of recent published data regarding this condition. This study describes clinicopathological pattern treatment outcome at Bugando Medical Centre, a tertiary care hospital northwestern was prospective histologically confirmed that conducted Center between July 2004 June 2014. A total 248 patients (M:F = 1.4:1) representing 2.4 % all malignancies during...

Methicillin resistant Staphylococcus aureus (MRSA) nasal carriage is a potential niche for spread and risk factor subsequent infections. Despite the fact that medical students are exposed to patients in hospital during their training, information on S. MRSA among Tanzania remains be dearth so as guide appropriate infection control preventive measures.A cross-sectional study involving 314 students, pre-clinical (n = 166) clinical 148), at Catholic University of Health Allied Sciences (CUHAS)...