A5101563150- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Bone fractures and treatments
- Shoulder Injury and Treatment
- Lipid Membrane Structure and Behavior
- MicroRNA in disease regulation
- Wound Healing and Treatments
- Plant Reproductive Biology
- Orthopedic Surgery and Rehabilitation
- Plant Molecular Biology Research
- Elbow and Forearm Trauma Treatment
- Hip and Femur Fractures
- Polymer Surface Interaction Studies
- Material Properties and Processing
- Studies on Chitinases and Chitosanases
- Artificial Intelligence in Healthcare and Education
- Advanced Glycation End Products research
- Optical Coherence Tomography Applications
- Carbon Nanotubes in Composites
- Advanced Cellulose Research Studies
- Bacterial Genetics and Biotechnology
- NF-κB Signaling Pathways
- Endodontics and Root Canal Treatments
- Electrospun Nanofibers in Biomedical Applications
- RNA regulation and disease
Xi'an Jiaotong University
2013-2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Massachusetts General Hospital
2024
Harvard University
2024
Guangxi Medical University
2020-2021
First Affiliated Hospital of GuangXi Medical University
2020-2021
Beijing University of Chinese Medicine
2020
Traditional Chinese Medicine Hospital of Kunshan
2017
Shanghai University of Traditional Chinese Medicine
2017
University of California, Los Angeles
2012
MicroRNAs (miRNAs) play important roles in many biological processes and are regarded as promising cancer biomarkers. Herein, a highly specific, one-step, rapid miRNAs detection strategy with attomolar sensitivity has been developed on the basis of target-triggered three-way junction (3-WJ) structure polymerase/nicking enzyme synergetic isothermal quadratic DNA machine (ESQM). To this end, 3-WJ probes (primer template) designed to selectively recognize target miRNA form stable trigger ESQM,...
Abstract Diabetic retinopathy (DR) is one of the most common microvascular complications diabetes mellitus and considered as a leading cause blindness. Oxidative stress inflammation are significant drivers for development DR. Eriodictyol, flavonoid compound, was proved to possess anti‐inflammatory, antioxidative, antidiabetic activities. However, role eriodictyol in DR has not been unveiled. In current study, we explored protective effects on high glucose (HG)‐induced rat retinal ganglial...
The E. coli single-stranded DNA-binding protein (SSB) is essential to viability. It plays key roles in DNA metabolism where it binds nascent single strands of and target proteins known as the SSB interactome. There are >2,000 tetramers per cell with 100-150 associated genome at any one time, either replication forks or sites repair. remaining 1,900 could constantly diffuse throughout cytosol be inner membrane observed for other metabolic enzymes. To visualize localization ascertain potential...
Abstract Cell shape plays important roles in regulating cell behavior; however, independently controlling three dimensions is a challenging undertaking, and how affects cellular responses to mechanical biochemical cues remains unclear. Here, we present hydrogel-based platform control by using sequentially formed hybrid hydrogels consisting of collagen alginate. By adjusting the cross-linking time alginate, fixed NIH 3T3 fibroblasts at different spreading states. Then, explored influence on...
Abstract Exosomes, which are nanoscale vesicles secreted by almost all cell types via paracrine pathways, play a crucial role in intercellular communication. For nearly decade, exosomes have been widely exploited to develop novel biologic therapeutic strategies for recalcitrant clinical problems such as chronic wounds. Due the excellent biocompatibility and immune stability of exosomes, exosome-based therapy has shown greater potential wound healing than other biotherapies (e.g.,...
Abstract Understanding interactions between cell-penetrating peptides and biomembrane under tension can help improve drug delivery elucidate mechanisms underlying fundamental cellular events. As far as the effect of membrane on translocation, it is generally thought that should disorder structure weaken its strength, thereby facilitating penetration. However, our coarse-grained molecular dynamics simulation results showed restrain polyarginine translocation across asymmetric this increases...
Electron acceptor possessing strong electron-withdrawing ability and exceptional stability is crucial for developing donor–acceptor–donor (D-A-D) structured aggregation-induced emission luminogens (AIEgens) with second near-infrared (NIR-II) emission. Although 6,7-diphenyl-[1,2,5] thiadiazolo [3,4-g] quinoxaline (PTQ) benzobisthiadiazole (BBT) are widely employed as NIR-II building blocks, they still suffer from limited capacity or inadequate chemo-stability under alkaline conditions....
Two single amino acid changes enable the adaptor protein TRAF5 to promote antiviral responses.
Previous studies have shown an attenuating effect of ginsenoside Re on myocardial injury induced by hypoxia/reoxygenation (H/R). However, the underlying mechanism remains unclear. This study was designed to determine which protects from H/R. HL-1 cells derived AT-1 mouse atrial cardiomyocyte tumor line were divided into control, H/R, and H/R + groups. Cell viability measured CCK-8 assay. ATP levels quantified enzymatic assays. Signaling pathway predicted network pharmacology analyses...
Accurate measurement of gingiva’s biomechanical properties in vivo has been an active field research but remained unmet challenge. Currently, there are no noninvasive tools that can accurately quantify tensile and shear moduli, which govern gingival health, with sufficiently high accuracy. This study presents the application high-frequency optical coherence elastography (OCE) for characterizing tissue both porcine models human subjects. Dynamic mechanical analysis, histology studies, strain...
We present a method of manipulative reduction, immobilisation and fixation using U-shaped plaster with the elbow in extension for extension-type supracondylar fractures humerus children. When is full extension, both extensor flexor muscles are neutralised during reduction carrying angle can be easily assessed thus preventing cubitus varus, most common complication. In order to evaluate efficiency this method, we compared clinical results new those conventional treatment. group 95 children...
We present a method of manipulative reduction, immobilisation and fixation using U-shaped plaster with the elbow in extension for extension-type supracondylar fractures humerus children. When is full extension, both extensor flexor muscles are neutralised during reduction carrying angle can be easily assessed thus preventing cubitus varus, most common complication. In order to evaluate efficiency this method, we compared clinical results new those conventional treatment. group 95 children...
To summarize the effectiveness of 3.5 mm T support plate fixation for simple postero-lateral tibial plateau fractures by posterolateral inverted L-shaped approach.Between March 2011 and January 2016, 13 patients with fracture were treated approach. Of cases, 6 male 7 female, aged 28 to 52 years (mean, 43 years). The left side was involved in 5 cases right 8 cases. causes injury traffic accidents falls 3 falling from height 4 All had fresh closed X-ray, CT three dimensional reconstruction,...
Synthetic biology enabling technologies have been harnessed to create new diagnostic technologies. However, most strategies involve error-prone amplification steps and limitations of accuracy in RNA detection. Here, a cell-free synthetic biology-powered biosensing strategy, termed as SHARK ( S ynthetic Enzyme h ift Signal A mplifier R elated Cas13a K nockdown Reaction), could efficiently accurately amplify signal by leveraging the collateral cleavage activated regulate enzyme synthesis....