A5031207887- Pesticide Exposure and Toxicity
- Liver physiology and pathology
- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- PI3K/AKT/mTOR signaling in cancer
- Toxic Organic Pollutants Impact
- Environmental Toxicology and Ecotoxicology
- MicroRNA in disease regulation
- Genomics, phytochemicals, and oxidative stress
- Drug Transport and Resistance Mechanisms
- Zebrafish Biomedical Research Applications
- Animal testing and alternatives
- Pesticide and Herbicide Environmental Studies
- Peroxisome Proliferator-Activated Receptors
- Alcohol Consumption and Health Effects
- Per- and polyfluoroalkyl substances research
- Proteoglycans and glycosaminoglycans research
- Physiological and biochemical adaptations
- Cancer Mechanisms and Therapy
- Birth, Development, and Health
- Pharmacogenetics and Drug Metabolism
- Air Quality and Health Impacts
- Ubiquitin and proteasome pathways
- Insect and Pesticide Research
- Fibroblast Growth Factor Research
Zhejiang University
2022-2023
Zhejiang University of Technology
2013-2022
Kanazawa University
2018-2019
Abstract Ferroptosis inducers have shown therapeutic potential in prostate cancer (PCa), but tumor heterogeneity poses a barrier to their efficacy. Distinguishing the regulators orchestrating metabolic crosstalk between cells could shed light on strategies more robustly activate ferroptosis. Here, we found that aberrant accumulation of jumonji domain containing 6 (JMJD6) proteins correlated with poorer prognosis PCa patients. Mechanistically, PCa-associated speckle type BTB/POZ protein...
The oxidative stress-induced osteoblast apoptosis plays an important role in the pathological process of osteoporosis, but roles autophagy stress and osteoblasts remain unclear. This study aimed to observe injury relationship between apoptosis.Mc3T3-E1 cells were stimulated with different concentrations (0.1, 0.5, 1 mM) hydrogen peroxide. cell viability was detected via counting kit 8 (CCK8) at time points (0, 2, 6, 8, 12 h), Western blotting flow cytometry, macrophage-derived chemokine...
Polycyclic aromatic hydrocarbons (PAHs) are the most common contaminants in environment. The primary focus on toxicity of PAHs is their ability to activate aryl hydrocarbon receptor (AhR)-mediated pathway and lead carcinogenesis different organisms. However, influence antioxidant system mammalian systems has received only limited attention. In present study, we observed that intraperitoneal injection 100 mg/kg 3-methylcholanthrene (3MC) into mice significantly increased reactive oxygen...
The potential for the exposure of humans and wildlife to environmental endocrine-disrupting chemicals (EDCs) has been increasing. Risk assessment such EDCs is primarily based on detecting main endpoints related endocrine reproductive systems, while effects glucose fat metabolism have only received limited attention. In this study, pubertal male C57BL/6J mice were orally administered 10 mg/kg body weight cypermethrin (CYP), 100 atrazine (ATZ), 0.1 17α-ethynyestradiol (EE2) 4 weeks then...
ABSTRACT Bifenthrin (BF), as a chiral pyrethroid, is widely used to control field and household pests in China. At present, the commercial BF mixed compound containing cis isomers (cis‐BF) including two enantiomers of 1R‐cis‐BF 1S‐cis‐BF. In present study, individual cis‐BF were separated by preparative supercritical fluid chromatography. Then, four week‐old adolescent male ICR mice orally administered 1S‐cis‐BF separately daily for 3 weeks at doses 0, 7.5 15 mg/kg/day, respectively. Results...
Glucocorticoids (GCs) have been widely detected in the aquatic system. However, hazardous effects of GCs on organisms were underestimated, and mechanisms GCs-induced toxic fish largely unknown. The zebrafish larvae at 3 dpf exposed to dexamethasone (DEX) for 48 h, underlying investigated current study. T cells ablated after being treated with 1, 3, 10, 30 100 μM DEX h. In addition, osteoporosis was induced regeneration caudal fin inhibited, by h-exposure DEX. transcriptomic analysis,...
Abstract Aberrant activation of the MET /hepatocyte growth factor ( HGF ) receptor participates in malignant behavior cancer cells, such as invasion‐metastasis and resistance to molecular targeted drugs. Many mutations extracellular region have been reported, but their significance is largely unknown. Here, we report dysregulation mutant originally found a lung patient with Val370 Asp370 (V370D) replacement located SEMA domain. ‐knockout cells were prepared reconstituted WT ‐ or V370D‐ ....
LNT is the major biologically active substance extracted from Lentinus edodes (L. edodes). Although functional and pharmacological studies have demonstrated that has multiple benefits for animals humans, safety assessment far sufficient. To evaluate potential risk, larval zebrafish were continuously exposed to varying concentrations of 120 h. The 96 h LC50 was determined be 1228 μg/mL, morphological defects including short body length, reduced eye swim bladder sizes yolk sac edema observed....
Non-native ligands for growth factor receptors with distinct chemical properties and different biological activities have the potential to become therapeutic applications. We previously generated MET/hepatocyte (HGF) receptor agonists using bivalent macrocyclic peptides. The highest MET-activating exhibited activity that was indistinguishable from effects of HGF. In this study, we investigated MET activation, signal characteristics, responses induced by a peptide partial agonist known as...
Abstract Non-native ligands for growth factor receptors that are generated by chemical synthesis applicable to therapeutics. However, non-native often regulate cellular signaling and biological responses in a different manner than native ligands. Generation of surrogate comparable is challenging need. Here we investigated changes signal transduction gene expression evoked bivalent macrocyclic peptide (aMD5-PEG11) capable high-affinity binding the MET/hepatocyte (HGF) receptor. Binding...