A5081190896- Bladder and Urothelial Cancer Treatments
- Galectins and Cancer Biology
- Heart Rate Variability and Autonomic Control
- Protein Tyrosine Phosphatases
- Blood Pressure and Hypertension Studies
- Cardiovascular Syncope and Autonomic Disorders
- Family Business Performance and Succession
- RNA modifications and cancer
- Cardiovascular Health and Disease Prevention
- Lung Cancer Treatments and Mutations
- Food Allergy and Anaphylaxis Research
- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Peptidase Inhibition and Analysis
- Urinary and Genital Oncology Studies
- Epigenetics and DNA Methylation
- Milk Quality and Mastitis in Dairy Cows
- Surface Roughness and Optical Measurements
- Infectious Diseases and Tuberculosis
- Lysosomal Storage Disorders Research
- Lung Cancer Research Studies
- Air Quality and Health Impacts
- Immune responses and vaccinations
- Sodium Intake and Health
- Health Systems, Economic Evaluations, Quality of Life
Pfizer (Germany)
2020-2025
Bielefeld University
2007-2023
University Hospital Magdeburg
2017-2022
Siemens (Germany)
2021
Marien Hospital Witten
2021
Ruhr University Bochum
2021
University Hospital Cologne
2021
University of Cologne
2019-2021
Pfizer (United States)
2021
Kaufmännische Krankenkasse
2020
Endovascular renal nerve ablation has been developed to treat resistant hypertension. In addition lowering efferent sympathetic activation, the intervention may attenuate central outflow through decreased afferent traffic, as evidenced by a recent case report. We tested hypothesis in 12 nonpreselected patients with difficult-to-control hypertension (aged 45-74 years) admitted for ablation. All received ≥ 3 antihypertensive medications at full doses, including diuretic. Electrocardiogram,...
Bilateral bipolar electric carotid sinus stimulation acutely reduced muscle sympathetic nerve activity (MSNA) and blood pressure (BP) in patients with resistant arterial hypertension but is no longer available. The second-generation device uses a smaller unilateral unipolar disk electrode to reduce invasiveness while saving battery life. We hypothesized that the lowers BP MSNA treatment-resistant hypertensive patients. Eighteen (9 women/9 men; 53±11 years; 33±5 kg/m 2 ) on stable medications...
This article examines the role of behavioral routines in decision making. In order to induce routines, participants were confronted with recurrent route decisions a computer-controlled trucking game, which allows for manipulation routine acquisition and strength. During final round time pressure novelty task presentation varied as between-factors. It was hypothesized that would increase likelihood maintenance deviation. Besides individual choices, response latencies self-reports additionally...
Based on the SYMPLICITY studies and CE (Conformité Européenne) certification, renal denervation is currently applied as a novel treatment of resistant hypertension in Europe. However, information proportion patients with qualifying for after thorough work-up adjustment remains scarce. The aim this study was to investigate eligible reasons noneligibility at 11 expert centers participating European Network COordinating Research Denervation treatment-resistant (ENCOReD). analysis included 731...
Zusammenfassung. In der vorliegenden längsschnittlichen Studie wurden Studienabbrecher mit Weiterstudierenden hinsichtlich einer Reihe relevanter Merkmale verglichen. Im Vordergrund standen motivationale Variablen, Aspekte des Selbstkonzepts, Lernstrategien, soziale Kompetenz, Wahrnehmung Lehrqualität, epistemologische Überzeugungen und die Finanzierung Studiums. Die Stichprobe setzte sich aus 47 Studienabbrechern (26 Frühabbrecher, 21 Spätabbrecher) Gruppe von 94 parallelisierten zusammen....
730 Background: Transurethral resection followed by induction and maintenance intravesical BCG is currently standard of care for patients with HR NMIBC. generally defined as stage T1, high grade (HG), carcinoma in situ, tumors >3 cm, variant histology, failure HG tumor, or lymphovascular invasion. Considering the variability definitions schedules, we analyzed evidence on utilization outcomes Methods: We conducted an SLR English-language real-world (RWE) studies published...
717 Background: Global guidelines recommend that High Risk Non-Muscle Invasive Bladder Cancer (HR NMIBC) patients (pts) receive 1-3 years of Bacillus Calmette-Guérin (BCG) treatment (Tx). This global real-world study aimed to understand pt characteristics, Tx patterns and impact the BCG shortage in pts with HR NMIBC. Methods: Physicians across EU5 (n=244), US (n=55), Japan (n=44) Canada (n=21) were recruited Adelphi NMIBC Disease Specific Programme: a cross-sectional survey retrospective...
738 Background: Neoadjuvant chemotherapy followed by Radical cystectomy (RC) is the current standard of care for muscle invasive bladder cancer (MIBC). RC associated with significant risks and quality life (QoL) implications. This real-world survey aimed to understand drivers behind why patients (pts) do not receive RC, alternative treatments initiated curative intent. Methods: Medical oncologists urologists across France, Germany, Italy, Spain, UK were recruited Adelphi MIBC Disease...
Depth sensors for three-dimensional object acquisition are widely used and available in many different sizes weight classes. The measuring method the accuracy depend on task to be performed. integration of depth mobile devices such as tablets smartphones is largely new. TrueDepth system iPhone X shows which measurement accuracies can achieved with these systems areas application addition consumer fun. investigations show that tasks millimeter range.
This study is concerned with how founding stories are sustained across multiple generations of employees in family firms and these influence organizational identification. Drawing on a social memory perspective narrative work, we explore the retold large agricultural firm. Our demonstrates that transform firsthand memories into collective through intertwining intradiegetic storytelling material relational processes. The effortful work remembering together familial relations, spaces, embodied...
Abstract We previously molecularly and clinically characterized Mazzanti syndrome, a RASopathy related to Noonan syndrome that is mostly caused by single recurrent missense variant (c.4A > G, p.Ser2Gly) in SHOC2, which encodes leucine-rich repeat-containing protein facilitating signal flow through the RAS-mitogen-associated kinase (MAPK) pathway. also documented pathogenic p.Ser2Gly substitution causes upregulation of MAPK signaling constitutive targeting SHOC2 plasma membrane due...
Autobiographical memory (AM) comprises memories of one's own past that are characterized by a sense subjective time and autonoetic awareness. AM deficits among the major complaints patients with Alzheimer's disease (AD) even in early or preclinical stages. However, little is known on association between cerebral alterations mild cognitive impairment (MCI) AD. In current study, AD MCI healthy controls underwent high-resolution magnetic resonance imaging (MRI) neuropsychological testing...
The superior clinical outcome of new continuous-flow left ventricular assist devices (LVADs) challenges the physiological dogma that cardiovascular autonomic homeostasis requires pulsatile blood flow and pressure. We tested hypothesis LVADs impair baroreflex control sympathetic nerve traffic, thus further exacerbating excitation. included 9 male heart failure patients (26–61 years; 18.9–28.3 kg/m 2 ) implanted with a LVAD. recorded ECG, respiration, finger pressure, brachial muscle activity....
Abstract Cardiovascular risk rapidly increased following exposure to air pollution. Changes in human autonomic regulation have been implicated based on epidemiological associations between estimates and indirect nervous system measurements. We conducted a mechanistic study test the hypothesis that, healthy older individuals, well-defined experimental ultrafine carbon particles (UFP) increases sympathetic activity more so with added ozone (O 3 ). Eighteen participants (age >50 years, 6...
Noonan syndrome is characterized by typical craniofacial dysmorphism, postnatal growth retardation, congenital heart defect, and learning difficulties belongs to the RASopathies, a group of neurodevelopmental disorders caused germline mutations in genes encoding components RAS‐MAPK pathway. Mutations RAF1 gene are associated with syndrome, high prevalence hypertrophic cardiomyopathy (HCM). cluster exons conserved region 2 (CR2), kinase activation segment CR3 domain, C‐terminus. We present...