Jean‐Philippe Lengelé
A5027263200- Blood Pressure and Hypertension Studies
- Renal and Vascular Pathologies
- Heart Rate Variability and Autonomic Control
- Abdominal vascular conditions and treatments
- Sodium Intake and Health
- Health Systems, Economic Evaluations, Quality of Life
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Hemodynamic Monitoring and Therapy
- Renal and related cancers
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Vasculitis and related conditions
- Hormonal Regulation and Hypertension
- Pancreatic function and diabetes
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic aneurysm repair treatments
- Migraine and Headache Studies
- Heart rate and cardiovascular health
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Issues in Pregnancy
- Blood disorders and treatments
- Hematological disorders and diagnostics
- Potassium and Related Disorders
- Moyamoya disease diagnosis and treatment
- Renin-Angiotensin System Studies
Grand Charleroi Hospital
2010-2024
UCLouvain
2007-2023
Cliniques Universitaires Saint-Luc
2010-2023
Radiance Technologies (United States)
2022-2023
University Hospital of Zurich
2012
The aim of this multicenter, open-label trial was to evaluate the safety and efficacy alcohol-mediated renal denervation using a novel catheter system (the Peregrine System Infusion Catheter) for infusion dehydrated alcohol as neurolytic agent into periarterial space. number hypertensive patients with uncontrolled blood pressure (BP) remains unacceptably high. sympathetic nervous has been identified an attractive therapeutic target. Forty-five hypertension on ≥3 antihypertensive medications...
ABSTRACT The diagnosis of nocardiosis, a severe opportunistic infection, is challenging. We assessed the specificity and sensitivity 16S rRNA Nocardia PCR-based assay performed on clinical samples. In this multicenter study (January 2014 to April 2015), patients who were admitted three hospitals had an underlying condition favoring radiological signs consistent with PCR result for sample included. Patients classified as negative control (NC) (negative culture results proven alternative or...
Since December 2015, the European/International Fibromuscular Dysplasia (FMD) Registry enrolled 1022 patients from 22 countries. We present their characteristics according to disease subtype, age and gender, as well predictors of widespread disease, aneurysms dissections.All diagnosed with FMD (string-of-beads or focal stenosis in at least one vascular bed) based on computed tomography angiography, magnetic resonance and/or catheter-based angiography were eligible. Patients predominantly...
Based on the SYMPLICITY studies and CE (Conformité Européenne) certification, renal denervation is currently applied as a novel treatment of resistant hypertension in Europe. However, information proportion patients with qualifying for after thorough work-up adjustment remains scarce. The aim this study was to investigate eligible reasons noneligibility at 11 expert centers participating European Network COordinating Research Denervation treatment-resistant (ENCOReD). analysis included 731...
IntroductionEtelcalcetide is an intravenous calcimimetic agent, effectively reducing parathyroid hormone levels in patients on maintenance hemodialysis (HD). The clinical impact of discontinuing etelcalcetide at the time kidney transplantation unknown.MethodsWe retrospectively reviewed all meeting predefined criteria who received a transplant our institution between 01/01/2015 and 12/31/2022. incidence parathyroidectomy evolution calcium, phosphate, intact PTH after was analyzed according to...
Objective: Previous trials of catheter-based renal-artery denervation (RDN) as treatment modality in resistant hypertension (rHT) generated unconvincing results. In the Investigator-Steered Project on Intravascular Denervation for Management Treatment-Resistant Hypertension (INSPiRED; NCT01505010), we optimized selection and management rHT patients.Methods: With ethical clearance to randomize 18 patients, three Belgian centers screened 29 patients with ≥3 drugs, whom 17 after optimization...
Background Cervical artery dissection (CeAD) is a frequent manifestation of fibromuscular dysplasia (FMD). However, risk factors for CeAD are unknown. We investigated associated with in the ARCADIA (Assessment Renal and Artery Dysplasia) registry. Methods Results The registry includes women or men aged ≥18 years, diagnosis renal, cervical, intracranial FMD, who were prospectively recruited at 16 university hospitals France Belgium. Diagnosis acute past inclusion was established on imaging...
The SYMPLICITY studies showed that renal denervation (RDN) is feasible as novel treatment for resistant hypertension. However, RDN a costly and invasive procedure, the long-term efficacy safety of which has not yet been proven. Therefore, we designed INSPiRED trial to compare blood pressure lowering vs usual medical therapy. randomized controlled enrolling 240 treatment-resistant hypertensive patients at 16 expert hypertension centres in Belgium. Eligible patients, aged 20-69 years old, have...
Purpose: Drug adherence may be a major problem in the therapy of hypertension and diagnosis resistance. Adherence can assessed by indirect methods or direct like drug detection urine with liquid chromatography-mass spectrometric methods.Materials methods: The current analysis included patients apparently treatment- resistant (TRH) referred for renal denervation (RDN) INSPiRED pilot trial (NCT 01505010). was repeatedly toxicological over time range up to 17 months total 18 patients.Results:...
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Background The European Society of Hypertension (ESH) guidelines recommend two possible strategies for the assessment cardiovascular risk (CVR) in essential hypertensive (HT) patients: categorical tables and SCORE charts. However, outcome these methods has not been compared. Objective We assessed CVR according to ESH charts adapted use Belgium 106 HT patients (mean age: 52.4 ± 12.9 years, male/female ratio: 46/60) without diabetes or other associated clinical conditions. Results distribution...
Background: Management of resistant hypertension (RHTN) is challenging and often implies the use complex polypharmacy interventional therapies. The main objectives this study were (i) to describe characteristics patients with RHTN referred two expert centres; (ii) identify predictors blood pressure (BP) control after intensive management. Methods: We reviewed electronic medical files all for Brussels Torino centres, extracted detailed clinical data, informations on drug adherence...
<i>Background/Aims:</i><i> HNF1B</i> nephropathy is characterized by dominantly inherited renal hypodysplasia with few cysts, slow decline and hypomagnesemia. Mice antenatal inactivation of <i>HNF1B </i>are polycystic kidneys, failure a profound decrease in cystic gene <i>(Pkhd1</i>, <i>Umod</i>, <i>Pkd2)</i> expression. after postnatal day 10 have no phenotype. <i>Methods:</i> Quantification mRNA expression...
Abstract Background Renal fibromuscular dysplasia (FMD) is typically diagnosed in young hypertensive women. The 2014 European FMD Consensus recommended screening all women <30 yo. However, the prevalence of renal young/middle‐aged remains unclear. aim this work was to assess and characteristics ≤50 Methods We retrospectively included consecutive aged years referred our Hypertension Unit from 2017 collected standardized information on patient modalities. Results Of 1083 incident patients,...