A5039172394- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Neurogenesis and neuroplasticity mechanisms
- Immune Cell Function and Interaction
- Prostate Cancer Treatment and Research
- T-cell and B-cell Immunology
- Advanced Fluorescence Microscopy Techniques
- Nerve injury and regeneration
- Schizophrenia research and treatment
- Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Mental Health Research Topics
- Estrogen and related hormone effects
- Memory and Neural Mechanisms
- Cellular Mechanics and Interactions
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
University of Southampton
2021-2024
Hospital Universitario 12 De Octubre
2009-2016
Centro de Investigación Biomédica en Red de Salud Mental
2009-2016
Instituto de Salud Carlos III
2016
University of Florida
2014
Abstract The functional Val158Met polymorphism (rs4680) located at the gene that codes for catechol‐ O ‐methyltransferase ( COMT ) has been extensively investigated in schizophrenia although current data are still controversial. Since activity is sexually dimorphic, we carried out two independent studies homogeneous samples of male and female Spanish schizophrenic patients. In males, found an association between homozygous Val genotype disorder, which resembled a recessive model P = 0.022;...
Polymorphisms of DRD2 and A NKK1 have been associated with psychiatric syndromes where there is believed to be an underlying learning process deficit such as addiction, post‐traumatic stress disorder psychopathy. We investigated the effects C957T ANKK1 Taq IA single nucleotide polymorphism (SNP), which psychopathic traits in alcoholic patients, on fear conditioning aversive priming healthy volunteers. found that SNP, but not was both differential skin conductance response effect. There were...
Background Natural killer (NK) cells are increasingly being recognized as agents for cancer immunotherapy. The cell immunoglobulin-like receptors (KIRs) expressed by NK and immunogenetic determinants of the outcome cancer. In particular, KIR2DS2 is associated with protective responses to several cancers also direct recognition targets in vitro. Due high homology between activating inhibitory KIR genes date, it has been challenging target individual therapeutic benefit. Methods A novel...
Abstract TaqIA is a polymorphism associated with addictions and dopamine-related traits. It located in the ankyrin repeat kinase domain containing 1 gene (ANKK1) nearby for dopamine D2 receptor (D2R). Since ANKK1 function unknown, TaqIA-associated traits have been explained only by differences D2R. Here we report studies mouse human brain using quantitative real-time PCR, Western blot, immunohistochemistry, flow cytometry. mRNA protein isoforms vary along neurodevelopment brain. In adult...
XPO1 (Exportin-1/CRM1) is a nuclear export protein that frequently overexpressed in cancer and functions as driver of oncogenesis. Currently small molecules target are being used the clinic anticancer agents. We identify for natural killer (NK) cells. Using immunopeptidomics, we have identified peptide derived from can be recognized by activating NK cell receptor KIR2DS2 context human leukocyte antigen–C. The endogenously processed presented to activate cells specifically through this...