A5053797796- Antibiotics Pharmacokinetics and Efficacy
- Hemoglobinopathies and Related Disorders
- Neonatal Respiratory Health Research
- Vestibular and auditory disorders
- Pharmaceutical studies and practices
- Pharmacological Effects and Toxicity Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Infant Development and Preterm Care
- Abdominal Surgery and Complications
- Traumatic Brain Injury Research
- Anesthesia and Sedative Agents
- Iron Metabolism and Disorders
- CAR-T cell therapy research
- Prenatal Screening and Diagnostics
- Biosimilars and Bioanalytical Methods
- Cerebral Palsy and Movement Disorders
- Neutropenia and Cancer Infections
- Acute Kidney Injury Research
- Birth, Development, and Health
- Neuroscience of respiration and sleep
- Nutrition and Health in Aging
- Autoimmune and Inflammatory Disorders Research
- Ergonomics and Musculoskeletal Disorders
Novartis (United States)
2020-2023
Boston Biomedical Research Institute
2023
Mater Adult Hospital
2021
Emmes (United States)
2013-2019
University of Florida
2016-2018
Columbus Oncology and Hematology Associates
2016-2018
St. Louis Children's Hospital
2017
University of British Columbia
2017
British Columbia Children's Hospital
2017
University of Missouri–Kansas City
2017
Acute human immunodeficiency virus type 1 (HIV-1) infection is a major contributor to transmission of HIV-1. An understanding acute HIV-1 may be important in the development treatment strategies eradicate or achieve functional cure.
Sickle cell disease is caused by a defect in the β-globin subunit of adult hemoglobin. hemoglobin polymerizes under hypoxic conditions, producing deformed red cells that hemolyze and cause vaso-occlusion results progressive organ damage early death. Elevated fetal levels protect against complications sickle disease. OTQ923, clustered regularly interspaced short palindromic repeats (CRISPR)–Cas9–edited CD34+ hematopoietic stem- progenitor-cell (HSPC) product, has targeted disruption HBG1 HBG2...
Canakinumab, a monoclonal antibody targeting proinflammatory cytokine interleukin-1β (IL-1β), improved hemoglobin levels while preventing recurrent cardiovascular events in the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS). This (CV) preventive effect was greater patients with TET2 mutations associated clonal hematopoiesis (CH). The current proteogenomic analysis aimed to understand clinical response canakinumab and underlying proteomic profiles context of CH anemia....
Abstract Background Pharmacogenomic variability can contribute to differences in pharmacokinetics and clinical responses. Pediatric patients with cerebral palsy genetic variations have not been studied for these potential differences. Objective To determine the sources of variation oral baclofen clearance Design add‐on study Setting Multicenter based academic pediatric clinics. Participants A total 49 who had participated an pharmacokinetic/pharmacodynamic study. Methods or Interventions Of...
Sodium nitroprusside is a direct-acting vasodilator used to lower blood pressure in the operating room and ICU. The efficacy of sodium has been analyzed few pediatric randomized trials. This study assesses safety following at least 12 hours IV infusion children.Randomized, double-blind withdrawal placebo study.ICUs.Pediatric patients younger than 17 years.Following 12-24 open-label titration, blinded or was administered (at stable rate end phase) for up 30 minutes.The primary measure whether...
Background: Trimethoprim-sulfamethoxazole (TMP-SMX) is an antimicrobial drug combination commonly prescribed in children and adults. The study objectives were to validate apply HPLC–MS/MS method quantify TMP-SMX dried plasma spots (DPS) urine (DUS), perform a comparability analysis with liquid matrices. Results: For TMP the validated range was 100–50,000 ng/ml for DPS 500–250,000 DUS; SMX, 1000–500,000 both DUS. Good agreement noted between DPS/DUS samples TMP, while only modest observed SMX...
Abstract Hydroxyurea (HU) is a crucial therapy for children with sickle cell anemia, but its off‐label use barrier to widespread acceptance. We found HU exposure not significantly altered by liquid vs capsule formulation, and weight‐based dosing schemes provide consistent exposure. recommended all starting as young 9 months of age anemia (SCA; HbSS HbSβspan 0 thalassemia); however; paucity pediatric data exists regarding the pharmacokinetics (PK) or exposure‐response relationship HU. This...
Trimethoprim (TMP)-sulfamethoxazole (SMX) is used to treat various types of infections, including community-acquired methicillin-resistant
Abstract Ketamine is an N‐methyl D‐aspartate receptor antagonist used off‐label to facilitate dissociative anesthesia in children undergoing invasive procedures. Available for both intravenous and intramuscular administration, ketamine commonly when vascular access limited. Pharmacokinetic (PK) data are sparse, the bioavailability of unknown. We performed 2 prospective PK studies receiving either or combined develop a pediatric population model using nonlinear mixed‐effects methods. applied...
Rifampin is active against methicillin-resistant staphylococcal species and tuberculosis (TB). We performed a multicenter, prospective pharmacokinetic (PK) safety study of intravenous rifampin in infants <121 days postnatal age (PNA). enrolled 27 infants; the median (range) gestational was 26 weeks (23 to 41 weeks), PNA 10 (0 84 days). collected 102 plasma PK samples from 22 analyzed data all infants. using population approach. best characterized by one-compartment model; drug clearance...
Anthropometric data prove valuable for screening and monitoring various medical conditions. In young infants, however, only weight, length head circumference are represented in publicly accessible databases.
Military service members often report both affective and vestibular complaints after mild traumatic brain injury (mTBI), but associations between symptoms deficits can be subtle inconsistent.From two complementary studies, one of military with persistent post-concussive mTBI (NCT01611194) the other adult volunteers no history (NCT01925963), were compared to postural control, gait, otolith visuospatial function.The studies enrolled 71 participants 75 normative controls. Participants had...
Abstract Introduction Surgical site infection (SSI) is the most common and costly complication of surgery. International guidelines recommend topical alcoholic chlorhexidine (CHX) before However, upper limb surgeons continue to use other antiseptics, citing a lack applicable evidence, concerns related open wounds tourniquets. This study aimed evaluate safety effectiveness different antiseptics Methods international multicentre prospective cohort recruited consecutive adults children who...
Sodium nitroprusside (SNP) is a potent vasodilator that has been used to induce deliberate hypotension in children during surgery involving significant blood loss, including craniofacial and spinal fusion procedures. SNP metabolism liberates cyanide, which may cause interference with cellular energy metabolism, leading metabolic acidosis central nervous system injury. We performed retrospective, case-control study determine whether the short-term intra-operative use of for associated...
This EM review article focuses on parameter expansion, a simple technique introduced in the PX-EM algorithm to make converge faster while maintaining its simplicity and stability. The primary objective concerns connection between expansion efficient inference. It reviews statistical interpretation of algorithm, terms inference via bias reduction, further unfolds mystery by looking at from different perspectives. In addition, it briefly discusses potential applications broader impact thinking...