A5060564361- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive biology and impacts on aquatic species
- Chromosomal and Genetic Variations
- Animal Genetics and Reproduction
- Genetic diversity and population structure
- Immune Cell Function and Interaction
- Identification and Quantification in Food
- Nematode management and characterization studies
- Fish Biology and Ecology Studies
- Legume Nitrogen Fixing Symbiosis
- Immunotherapy and Immune Responses
- Genetic and phenotypic traits in livestock
- Sperm and Testicular Function
- Muscle and Compartmental Disorders
- Fish biology, ecology, and behavior
- Genomics and Phylogenetic Studies
- Aquaculture Nutrition and Growth
- Dialysis and Renal Disease Management
- Ichthyology and Marine Biology
- Aquatic life and conservation
- T-cell and B-cell Immunology
- Acute Kidney Injury Research
- Parasite Biology and Host Interactions
- Aquaculture disease management and microbiota
- Immune cells in cancer
Inserm
2023-2025
Université de Toulouse
2018-2025
Centre National de la Recherche Scientifique
2023-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2019-2024
Institut Toulousain des Maladies Infectieuses et Inflammatoires
2023-2024
Génétique Physiologie et Systèmes d'Elevage
2019-2023
École Nationale Vétérinaire de Toulouse
2019-2023
Université Toulouse III - Paul Sabatier
2023
Mathématiques et Informatique Appliquées
2019-2022
Département Mathématiques et Informatique Appliquées
2019-2022
Accurate species phylogenies are a prerequisite for all evolutionary research. Teleosts the largest and most diversified group of extant vertebrates, but relationships among their three oldest lineages remain unresolved. On basis seven high-quality new genome assemblies in Elopomorpha (tarpons, eels), we revisited topology deepest branches teleost phylogeny using independent gene sequence chromosomal rearrangement phylogenomic approaches. These analyses converged to single scenario that...
Abstract Yellow perch, Perca flavescens , is an ecologically and economically important species native to a large portion of the northern United States southern Canada also promising candidate for aquaculture. However, no yellow perch reference genome has been available facilitate improvements in both fisheries aquaculture management practices. By combining Oxford Nanopore Technologies long‐reads, 10X Genomics Illumina short linked reads chromosome contact map produced with Hi‐C, we...
The evolution of sex determination (SD) in teleosts is amazingly dynamic, as reflected by the variety different master sex-determining genes identified. Pangasiids are economically important catfishes South Asian countries, but little known about their SD system. Here, we generated novel genomic resources for 12 and characterized Based on a Pangasianodon hypophthalmus chromosome-scale genome assembly, identified an anti-Müllerian hormone receptor type Ⅱ gene (amhr2) duplication, which was...
The Pacific halibut (Hippoglossus stenolepis) is a key species in the North Ocean and Bering Sea ecosystems, where it also supports important fisheries. However, lack of genomic resources limits our understanding evolutionary, environmental anthropogenic forces affecting life history characteristics prevents application tools fisheries management conservation efforts. In present study, we report on first generation high-quality chromosome-level assembly genome, with an estimated size 602 Mb,...
The Percidae family comprises many fish species of major importance for aquaculture and fisheries. Based on three new chromosome-scale assemblies in Perca fluviatilis, schrenkii, Sander vitreus along with additional percid reference genomes, we provide an evolutionary comparative genomic analysis their sex-determination systems.
Abstract Protective immune responses require close interactions between conventional (Tconv) and regulatory T cells (Treg). The extracellular mediators signaling events that regulate the crosstalk these CD4 + cell subsets have been extensively characterized. However, how Tconv translate Treg-dependent suppressive signals at chromatin level remains largely unknown. Here we show, using a murine bone marrow allograft model in which graft rejection is coordinated by can be inhibited Treg,...
Abstract The genus Oryzias consists of 35 medaka-fish species each exhibiting various ecological, morphological and physiological peculiarities adaptations. Beyond being a comprehensive phylogenetic group for studying intra-genus evolution several traits like sex determination, behavior, morphology or adaptation through comparative genomic approaches, all medaka share many advantages experimental model organisms including small size short generation time, transparent embryos genome editing...
Abstract Discovered in the 1960s, Meloidogyne graminicola is a root‐knot nematode species considered as major threat to rice production. Yet, its origin, genomic structure, and intraspecific diversity are poorly understood. So far, such studies have been limited by unavailability of sufficiently complete well‐assembled genome. In this study, using combination Oxford Nanopore Technologies Illumina sequencing data, we generated highly contiguous reference genome (283 scaffolds with an N50...
Abstract Background Goldfish is an important model for various areas of research, including neural development and behavior a species significant importance in aquaculture, especially as ornamental species. It has male heterogametic (XX/XY) sex determination system that relies on both genetic environmental factors, with high temperatures being able to produce female-to-male reversal. Little, however, currently known the molecular basis this cyprinid model. Here we used sequencing approaches...
Abstract Arapaima gigas is one of the largest freshwater fish species high ecological and economic importance. Overfishing habitat destruction are severe threats to remaining wild populations. By incorporating a chromosomal Hi-C contact map, we improved arapaima genome assembly chromosome-level, revealing an unexpected degree chromosome rearrangements during evolution bonytongues (Osteoglossiformes). Combining this new with pool-sequencing male female genomes, identified id2bbY , duplicated...
Augmenting the portfolio of therapeutics for type 2-driven diseases is crucial to address unmet clinical needs and design personalized treatment schemes. An attractive therapy such would consist in targeting recruitment T helper 2 (Th2) lymphocytes inflammatory sites. Herein, we show degradation filamins (FLN) a b by ASB2α E3 ubiquitin ligase as mechanism sustaining Th2 lymphocyte functions. Low levels FLNa FLNb confer an elongated shape associated with efficient αVβ3 integrin-dependent cell...
The role of macrophages in the development rhabdomyolysis-induced acute kidney injury (RM-AKI) has been established, but an in-depth understanding changes immune landscape could help to improve targeted strategies. Whereas senescence is usually associated with chronic processes, we also wished explore whether occur AKI and senolytics act on cells. Single-cell RNA sequencing was used murine glycerol-induced RM-AKI model dissect transcriptomic characteristics CD45+ live cells sorted from...
ABSTRACT The evolution of sex determination (SD) mechanisms in teleost fishes is amazingly dynamic, as reflected by the variety different master sex-determining genes identified, even sometimes among closely related species. Pangasiids are a group economically important catfishes many South-Asian countries, but little known about their system. Here, we generated novel genomic resources for 12 Pangasiid species and provided first characterization SD Based on an Oxford Nanopore long-read...
Abstract Accurate species phylogenies are a prerequisite for evolutionary research. Teleosts by far the largest and most diversified group of extant vertebrates, but relationships among three oldest lineages teleosts remain unresolved. Based on seven high-quality new genome assemblies in Elopomorpha (tarpons, eels), we revisited topology deepest branches teleost phylogeny using independent gene sequence chromosomal rearrangement phylogenomic approaches. These analyses converged to single...
<title>Abstract</title> Augmenting the portfolio of therapeutics for type 2-driven diseases is crucial to address unmet clinical needs and design personalized treatment schemes. An attractive therapy such would consist in targeting recruitment T helper 2 (Th2) lymphocytes inflammatory sites. Herein, we unravel degradation filamins (FLN) A B by ASB2α E3 ubiquitin ligase as a mechanism sustaining Th2 lymphocyte functions. Low levels FLNa FLNb confer an elongated shape associated with efficient...
ABSTRACT The Percidae family comprises many fish species of major importance for aquaculture and fisheries. Based on three new chromosome-scale assemblies in Perca fluviatilis , schrenkii Sander vitreus along with additional percid reference genomes, we provide an evolutionary comparative genomic analysis their sex-determination systems. We explored the fate a duplicated anti-Mullerian hormone receptor type-2 gene ( amhr2bY ), previously suggested to be master sex determining (MSD) P....
The Percidae family comprises many fish species of major importance for aquaculture and fisheries. Based on three new chromosome-scale assemblies in Perca fluviatilis, schrenkii Sander vitreus along with additional percid reference genomes, we provide an evolutionary comparative genomic analysis their sex-determination systems. We explored the fate a duplicated anti-Mullerian hormone receptor type-2 gene (amhr2bY), previously suggested to be master sex determining (MSD) P. flavescens....
ABSTRACT Background Yellow perch, Perca flavescens , is an ecologically and commercially important species native to a large portion of the northern United States southern Canada. It also promising candidate for aquaculture. No yellow perch reference genome, however, has been available facilitate improvements in both fisheries aquaculture management practices. Findings By combining Oxford Nanopore Technologies long-reads, 10X genomics Illumina short linked reads chromosome contact map...
Abstract Background Goldfish is an important model for various areas of research, including neural development and behavior a species significant importance in aquaculture, especially as ornamental species. It has male heterogametic (XX/XY) sex determination system that relies on both genetic environmental factors, with high temperatures being able to produce female-to-male reversal. Little, however, currently known the molecular basis this cyprinid model. We used sequencing approaches...
Abstract Background and Aims Worldwide, acute kidney injury (AKI) has an incidence of 13.3 million cases per year leading to 1.7 deaths. Rhabdomyolysis (RM) accounts for 10% the AKI cases, frequently occurs due falling (often in elderly), crush syndrome or exposure drugs. By causing skeletal muscle damage, RM leads a release contents such as myoglobin into circulatory system trigger renal sterile inflammation. The role macrophages driving inflammatory phase RM-AKI lesions fibrosis-related...
ABSTRACT Background The genus Oryzias is constituted of 35 medaka-fish species each exhibiting various ecological, morphological and physiological peculiarities adaptations. Beyond being a comprehensive phylogenetic group for studying intra-genus evolution several traits like sex determination, behaviour, morphology or adaptation through comparative genomic approaches, all medaka share many advantages experimental model organisms including small size short generation time, transparent...