A5080341644- Mycotoxins in Agriculture and Food
- Animal Nutrition and Physiology
- Insect and Pesticide Research
- Pesticide Residue Analysis and Safety
- Microbial infections and disease research
- Veterinary medicine and infectious diseases
- Antibiotics Pharmacokinetics and Efficacy
- Animal Behavior and Welfare Studies
- Agricultural safety and regulations
- Wheat and Barley Genetics and Pathology
- Plant and fungal interactions
- Bird parasitology and diseases
- Carcinogens and Genotoxicity Assessment
- Antibiotic Resistance in Bacteria
- Viral gastroenteritis research and epidemiology
- Coccidia and coccidiosis research
- Salmonella and Campylobacter epidemiology
- Plant Toxicity and Pharmacological Properties
- Clostridium difficile and Clostridium perfringens research
- Drug Transport and Resistance Mechanisms
- Livestock and Poultry Management
- Inflammatory mediators and NSAID effects
- Pharmacological Effects and Assays
- Plant Disease Resistance and Genetics
- Effects of Environmental Stressors on Livestock
Ghent University
2016-2025
Ghent University Hospital
2023
Salisbury University
2018
Both mycotoxin contamination of feed and Clostridium perfringens-induced necrotic enteritis have an increasing global economic impact on poultry production. Especially the Fusarium deoxynivalenol (DON) is a common contaminant. This study aimed at examining predisposing effect DON development in broiler chickens. An experimental perfringens infection revealed that DON, level 3,000 to 4,000 µg/kg feed, increased percentage birds with subclinical from 20±2.6% 47±3.0% (P<0.001). significantly...
Monitoring animal welfare on farms and in research settings is attracting increasing interest, both for ethical reasons improving productivity through the early detection of stress or diseases. In contrast to video-based monitoring, which requires good light conditions has difficulty tracking specific animals, recent advances miniaturization wearable devices allow collection acceleration location data track individual behavior. However, broilers, there are several challenges address when...
The poultry industry relies on highly efficient production systems. For sustainable food production, where maintaining broiler welfare is crucial, it essential to have robust data collection systems and automated methods for assessing health welfare. This paper presents the development implementation of an acoustic system designed detect differentiate between four distinct vocalizations chickens-pleasure notes, distress calls, short peeps, warbles-while filtering out background noise other...
Fumonisins (FBs) are mycotoxins produced by Fusarium fungi. This study aimed to investigate the effect of these feed contaminants on intestinal morphology and microbiota composition, evaluate whether FBs predispose broilers necrotic enteritis. One-day-old broiler chicks were divided into a group fed control diet, contaminated diet (18.6 mg FB1+FB2/kg feed). A significant increase in plasma sphinganine/sphingosine ratio FBs-treated (0.21 ± 0.016) compared (0.14 0.014) indicated disturbance...
Deoxynivalenol (DON) and fumonisins (FBs) are secondary metabolites produced by Fusarium fungi that frequently contaminate broiler feed. The aim of this study was to investigate the impact DON and/or FBs on intestinal barrier in chickens, more specifically mucus layer antioxidative response oxidative stress. One-day-old chicks were divided into four groups, each consisting eight pens seven birds each, fed for 15 days either a control diet, DON-contaminated diet (4.6 mg DON/kg feed),...
Forages are important components of dairy cattle rations but might harbor a plethora mycotoxins. Ruminants considered to be less susceptible the adverse health effects mycotoxins, mainly because ruminal microflora degrades certain Yet, impairment degradation capacity or high stability toxins can entail that intestinal epithelium is exposed significant mycotoxin amounts. The aims our study were assess i) occurrence in maize silage and ii) cytotoxicity relevant mycotoxins on bovine cells. In...
Mycotoxins are common in grains sub-Saharan Africa and negatively impact human animal health production. This study assessed occurrences of mycotoxins, some plant, bacterial metabolites 16 dairy 27 poultry feeds, 24 feed ingredients from Machakos town, Kenya, February August 2019. We analyzed the samples using a validated multi-toxin liquid chromatography-tandem mass spectrometry method. A total 153 toxins, were detected samples. All co-contaminated with 21 to 116 different mycotoxins and/or...
In 2004, the EFSA Panel on Contaminants in Food Chain (CONTAM) adopted a Scientific Opinion risks to animal health and transfer from feed food of origin related presence ochratoxin A (OTA) feed. The European Commission requested assess newly available scientific information update 2004 Opinion. OTA is produced by several fungi genera Aspergillus Penicillium. most species it rapidly extensively absorbed gastro-intestinal tract, binds strongly plasma albumins mainly detoxified alpha (OTalpha)...
The goal of this study was to determine the absolute oral bioavailability, (presystemic) hydrolysis and toxicokinetic characteristics deoxynivalenol, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol in broiler chickens pigs. Crossover animal trials were performed with intravenous administration broilers Plasma concentrations analyzed by using liquid chromatography–tandem mass spectrometry, data processed via a tailor-made compartmental analysis. results showed that absorbed fraction after...
Aflatoxins (AFs) frequently contaminate food and animal feeds, especially in (sub) tropical countries. If animals consume contaminated AFs (mainly aflatoxin B1 (AFB1), B2 (AFB2), G1 (AFG1), G2 (AFG2) their major metabolites M1 (AFM1) M2 (AFM2)) can be transferred to edible tissues products, such as eggs, liver muscle tissue milk, which ultimately reach the human chain. Currently, European Union has established a maximum level for AFM1 milk (0.05 µg kg−1). Dietary adsorbents, bentonite clay,...
Scarcity of feed ingredients, unregulated mills, and limited monitoring mycotoxin levels in increase the risk exposure for poultry sub-Saharan Africa. This study examined mycotoxins from 122 Kenyan broiler farms an association between on-farm handling practices levels. Using a validated multi-mycotoxin liquid chromatography-tandem mass spectrometry method (LC-MS/MS), all samples contained at least one 93 % (n=113) had >3 mycotoxins. The most prevalent EU-regulated detected were fumonisins...
Analysis of the blood proteome allows identification proteins related to changes upon certain physiological conditions. The pathophysiology necrotic enteritis (NE) has been extensively studied. While intestinal have very well documented, data addressing NE-induced alterations in are scant, although these might merit diagnostics. In light recent technological advancements proteomics and pressing need for tools access gut health, current study employs mass-spectrometry (MS)-based identify...
Abstract The mycotoxins alternariol (AOH) and monomethyl ether (AME), produced by Alternaria spp . , are common contaminants of food feed a potential threat to animal human health. To date, the most prominent data gaps for their comprehensive risk assessment concern information on in vivo absorption, distribution, metabolism excretion (ADME) toxicokinetic behavior. aim this study was determine absolute oral bioavailability, quantitative characteristics biotransformation AOH AME pigs, using...
After oral (PO) and intravenous (IV) administration of zearalenone (ZEN) to broiler chickens, laying hens, turkey poults, the mycotoxin was rapidly absorbed (Tmax = 0.32-0.97 h) in all three species; however, absolute bioavailability low (F% 6.87-10.28%). Next, also a rapid elimination poultry species observed (T(1/2el) 0.29-0.46 h). Both α- β-zearalenone (ZEL) were formed equally after IV studied, whereas an increased biotransformation β-ZEL demonstrated PO administration, indicating...
A toxicokinetic study of the Fusarium mycotoxins enniatin B1 (ENN B1) and B B) was performed in broiler chickens. Each animal received ENN or orally via an intracrop bolus intravenously at a dose 0.2 mg/kg body weight. Both enniatins were poorly absorbed after oral administration, with absolute bioavailabilities 0.05 0.11 for ENNs B, respectively. readily distributed to tissues, mean volumes distribution 25.09 33.91 L/kg The total clearance rather high, namely, 6.63 7.10 L/h/kg Finally,...