Célina Ducroux
A5051577819- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- S100 Proteins and Annexins
- Atrial Fibrillation Management and Outcomes
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroinflammation and Neurodegeneration Mechanisms
- Vascular Malformations Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Peripheral Artery Disease Management
- Retinal and Optic Conditions
- Neurosurgical Procedures and Complications
- Neurological Disorders and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- MRI in cancer diagnosis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Meta-analysis and systematic reviews
- Medical Imaging and Analysis
- Lipoproteins and Cardiovascular Health
- Radiomics and Machine Learning in Medical Imaging
Fondation de Rothschild
2018-2024
Ottawa Hospital
2020-2024
University of Ottawa
2023-2024
Université de Montréal
2020-2024
Centre Hospitalier de l’Université de Montréal
2016-2024
Ottawa Hospital Research Institute
2023-2024
Fondation Ophtalmologique Adolphe de Rothschild
2018-2021
Deleted Institution
2021
Sorbonne Université
2017-2020
Inserm
2017-2020
Background and Purpose— Neutrophil Extracellular Traps (NETs) are DNA extracellular networks decorated with histones granular proteins produced by activated neutrophils. NETs have been identified as major triggers structural factors of thrombosis. A recent study designated threads from a potential therapeutic target for improving tissue-type plasminogen activator (tPA)-induced thrombolysis in acute coronary syndrome. The aim this was to assess the presence thrombi retrieved during...
Background and Purpose— Admission hyperglycemia is associated with a poor outcome in acute ischemic stroke. How impacts the pathophysiology of stroke remains largely unknown. We investigated how preexisting increases ischemia/reperfusion cerebral injury. Methods— Normoglycemic streptozotocin-treated hyperglycemic rats were subjected to transient middle artery occlusion. Infarct growth brain perfusion assessed by magnetic resonance imaging. Markers platelet, coagulation, neutrophil activation...
Background The ‘first pass effect’ (FPE), which was originally described with stent retrievers, designates a (near-)complete revascularization obtained after single device no rescue therapy, and is associated improved clinical outcome decreased mortality. Objective We report the rate benefits of FPE in Aspiration versus Stent Retriever (ASTER) trial. Materials methods ASTER randomized trial comparing angiographic retriever (SR) contact aspiration (CA) thrombectomy techniques, assessed by an...
Background Previous experimental studies have shown that downstream microvascular thromboinflammation is involved in brain damage from acute ischemic stroke. Using intravital microscopy, we investigated and characterized the sequence of an ischemia/reperfusion stroke model. Methods Results Rats underwent transient monofilament middle cerebral artery (MCA) occlusion. Cerebral microcirculation MCA territory was exposed through a craniotomy analyzed using real‐time imaging coupled with laser...
Background and Purpose— We aimed to study the intrarater interrater agreement of clinicians attributing DWI-ASPECTS (Diffusion-Weighted Imaging–Alberta Stroke Program Early Computed Tomography Scores) DWI-FLAIR Imaging–Fluid Attenuated Inversion Recovery) mismatch in patients with acute ischemic stroke referred for mechanical thrombectomy. Methods— Eighteen raters independently scored anonymized magnetic resonance imaging scans 30 participants from a multicentre thrombectomy trial, 2...
ABSTRACT: This is an observational cohort study comparing 156 patients evaluated for acute stroke between March 30 and May 31, 2020 at a comprehensive center with 138 during the corresponding time period in 2019. During pandemic, proportion of COVID-19 positive was low (3%), from symptom onset to hospital presentation significantly longer, smaller underwent reperfusion therapy. Among directly our institution, door-to-needle door-to-recanalization metrics were longer. Our findings support...
Background and purpose An external validation of the selection criteria diffusion‐weighted imaging or computerized tomography perfusion assessment with clinical mismatch in triage wake‐up late‐presenting strokes undergoing Neurointervention Trevo ( DAWN ) Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke DEFUSE 3) trials was conducted a cohort unknown onset stroke UOS patients treated thrombectomy. Methods A selected from prospectively collected thrombectomy database to...
Purpose We aimed to assess the agreement between study investigators and core laboratory (core lab) of a thrombectomy trial for imaging scores. Methods The Alberta Stroke Program Early CT Score (ASPECTS), European Collaborative Acute Study (ECASS) hemorrhagic transformation (HT) classification, Thrombolysis In Cerebral Infarction (TICI) scores as recorded by were compared with lab in order interrater agreement, using Cohen’s unweighted weighted kappa statistics. Results There frequent...
Mechanical thrombectomy (MT) is the standard of care for patients with anterior circulation large vessel occlusion. Early neurological improvement (ENI), defined as a reduction ≥ 8 on National Institutes Health Stroke Scale (NIHSS) compared baseline score, or an NIHSS score 0 1 at 24 h after MT, strong predictor 3-month favorable outcome in such patients. The impact ENI MT stroke basilar artery occlusion (BAO) not clear. We aimed to study effects BAO.We performed retrospective analysis...
An increasing number of centers not necessarily equipped with biplane (BP) angiosuites are performing mechanical thrombectomy (MT) in acute ischemic stroke patients. We assessed whether MT performed on single-plane (SP) is equivalent terms safety, effectiveness, radiation and contrast agent exposure. Consecutive patients treated by four high volume between January 2014 May 2017 were included. Demographic characteristics compared SP BP. Of 906 MT, 576 (64%) handled a BP system. After...
Background and Purpose— Previous experimental studies found that the infusion of human purified nascent HDL (high-density lipoprotein) significantly reduced infarct volume hemorrhagic transformation rate by decreasing neutrophil recruitment. ApoA1-M (apolipoprotein A1-Milano) is a natural variant ApoA1 confers protection against atherosclerosis. Recombinant has been formulated as complex with phospholipids to mimic properties HDL. The aim this study was assess impact intravenous in transient...
In the settings of thrombectomy, first-pass effect (FPE), defined by a complete recanalization after one pass with no rescue therapy, has been shown to be associated an improved outcome. As this phenomenon predominantly described in anterior circulation strokes, we aimed study prevalence, outcomes, and predictors FPE patients basilar artery occlusion.From prospective multicentric registry, collected data all consecutive occlusion who underwent thrombectomy compared outcomes achieved those...
Oral anticoagulation (OAC) prevents stroke in atrial fibrillation, yet a residual risk remains. In this single-center retrospective analysis of acute ischemic patients despite OAC, suboptimal OAC treatment is common (30%: inappropriate dosing (17%); patient non-adherence (13%)). Other causes included interruption (14.5%), competing mechanism (11.0%), and undetermined breakthrough 44.5%. Overall, easily modifiable are common. Accordingly, strategies to improve compliance, including...
Patients with acute basilar artery occlusion (BAO) and low-to-moderate symptoms (National Institutes of Health Stroke Scale [NIHSS] < 10) are poorly represented in thrombectomy trials. Our objective is to compare best medical management (BMT) this population.