A5030339218- Epigenetics and DNA Methylation
- Effects and risks of endocrine disrupting chemicals
- Genetic Syndromes and Imprinting
- Toxic Organic Pollutants Impact
- Prenatal Screening and Diagnostics
- Birth, Development, and Health
- Renal and related cancers
- Quantum Dots Synthesis And Properties
- Carcinogens and Genotoxicity Assessment
- Gold and Silver Nanoparticles Synthesis and Applications
- High-Temperature Coating Behaviors
- COVID-19 Impact on Reproduction
- Additive Manufacturing Materials and Processes
- Weed Control and Herbicide Applications
- Spine and Intervertebral Disc Pathology
- Sepsis Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- Spinal Hematomas and Complications
- 2D Materials and Applications
- High Entropy Alloys Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer Mechanisms and Therapy
- Molecular Junctions and Nanostructures
- Plant tissue culture and regeneration
- Allelopathy and phytotoxic interactions
Peking University
2021-2024
Peking University Third Hospital
2021-2024
Shandong Center for Disease Control and Prevention
2024
Jiangmen Central Hospital
2024
Beijing Obstetrics and Gynecology Hospital
2022-2023
Shaanxi University of Science and Technology
2022-2023
Ministry of Education of the People's Republic of China
2021-2022
Shandong Normal University
2019-2021
Zero to Three
2020
Guizhou Electromechanical Research and Design Institute
2018
Abstract Transcriptomic and epigenetic alterations during early embryo development have been proven to play essential roles in regulating the cell fate. Nowadays, advances single-cell transcriptomics epigenomics profiling techniques provide large volumes of data for understanding molecular regulatory mechanisms embryos facilitate investigation assisted reproductive technology as well preimplantation genetic testing. However, lack integrated collection unified analytic procedures greatly...
The aim of this study was to examine the effect TXL, a Chinese medicine prescription, on cerebral microcirculatory disturbances after pMCAO in mice using TPLSM and further explore underlying mechanisms.Adlut male C57BL/6J were subjected orally administered with TXL (3.0, 1.5 0.75 g/kg/d) at 1, 3, 21 hours pMCAO. following parameters examined 6 24 pMCAO: neurological deficits, infarct volume, BBB permeability, microvessel structure, brain microcirculation (TPLSM imaging), vasoactive factors,...
Abstract Polychlorinated biphenyls (PCBs) are a class of persistent organic environmental pollutants with total 209 homologs. The homolog 2,3′,4,4′,5‐pentachlorobiphenyl (PCB118) is one the most important dioxin‐like PCBs and highly toxic. PCB118 can accumulate in human tissues, serum breast milk, which leads to direct exposure fetus during development. In present study, pregnant mice were exposed 0, 20 100 μg/kg/day stage fetal primordial germ cell migration. Compared control group, we...
Gametogenesis plays an important role in the reproduction and evolution of species. The transcriptomic epigenetic alterations this process can influence reproductive capacity, fertilization, embryonic development. rapidly increasing single-cell studies have provided valuable multi-omics resources. However, data from different layers sequencing platforms not been uniformed integrated, which greatly limits their use for exploring molecular mechanisms that underlie oogenesis spermatogenesis....
Abstract BRG1‐associated factor 250a (BAF250a) is a component of the SWI/SNF adenosine triphosphate‐dependent chromatin remodeling complex, which has been shown to control structure and transcription. BAF250a was reported be key gene regulatory machinery in embryonic stem cells controlling self‐renewal, differentiation, cell lineage decisions. Here we constructed Baf250a F/F ; Gdf9‐cre ( CKO ) mice specifically delete oocytes investigate role maternal female germ embryo development. Our...
Polychlorinated biphenyls (PCBs) are synthetic biphenyl compounds with high toxicity. There a total of 209 homologs, among which 2,3',4,4',5-pentachlorobiphenyl (PCB118) is one the dioxin-like PCBs. PCB118 can accumulate in pregnant mice, leading to fetus directly exposure during development. The stage migration mouse primordial germ cells ranges from 8.5 13.5 days pregnancy, undergoing genome-wide DNA demethylation process. In this study, mice were exposed 20 μg/kg/day and 100 pregnancy....
Infertility has become a global health issue, with the number of people suffering from disease increasing year by year, and ART offering great promise for infertility treatment. However, regulation early embryonic development is complicated series processes takes place, including maternal-to-zygotic transition. In addition, developmental arrest frequently observed during human development. this study, we performed single-cell RNA sequencing on biopsied blastomere eight-cell embryos tracked...
Polychlorinated biphenyls (PCBs) are persistent organic pollutants, and the widespread use of PCBs has had adverse effects on human animal health. This study experiment explored 2,3′,4,4′,5-pentachlorobiphenyl (PCB118) mammalian reproductive system. PCB118 was administered to pregnant mice from 7.5 12.5 days gestation; F1 were obtained system male examined. damaged in mice, as evidenced by negative testicular organ coefficient (testes weight/bodyweight), a decrease diameter seminiferous...
As the aircraft has a high overall weight requirement, it is indispensable to make lightweight design of gun. The structural optimization certain gun closed bearing band sabot studied based on variable density method. And new structure obtained. unit and minimum flexibility are taken as objective function. volume reduction percentage, equilibrium equation engineering manufacturing constraint. results finite element analysis optimized show that reduced by 9.7%. stiffness strength slightly...
Objective To explore the application effects of structured intervention model on protective restriction in psychiatric inpatients. Methods The study investigated 918 inpatients hospitalized from January 2013 to December 2014. The participants were randomly divided into group (n=469) and control (n=449). patients received based model. A standard risk assessment was applied before after restriction. routine protection rate, duration, day-night time compared between two...
Abstract Gametogenesis plays an important role in the reproduction and evolution of species. The transcriptomic epigenetic alterations this process can influence reproductive capacity, fertilization, embryonic development. rapidly increasing single-cell studies have provided valuable multi-omics resources. However, data from different layers sequencing platforms not been uniformed integrated, which greatly limits their use for exploring molecular mechanisms that underlie oogenesis...