A5062794220- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Neonatal Respiratory Health Research
- Monoclonal and Polyclonal Antibodies Research
- Allergic Rhinitis and Sensitization
- Immune cells in cancer
- 3D Printing in Biomedical Research
- Cancer Immunotherapy and Biomarkers
- Dermatology and Skin Diseases
- Science, Research, and Medicine
- Autoimmune and Inflammatory Disorders Research
- Respiratory viral infections research
- Immune Response and Inflammation
- Amyotrophic Lateral Sclerosis Research
- SARS-CoV-2 and COVID-19 Research
- Kawasaki Disease and Coronary Complications
- Food Allergy and Anaphylaxis Research
- Adipokines, Inflammation, and Metabolic Diseases
- COVID-19 Clinical Research Studies
- Bacteriophages and microbial interactions
Ghent University
2016-2024
Erasmus MC
2024
Ghent University Hospital
2010-2024
VIB-UGent Center for Inflammation Research
2016-2024
VIB Single Cell Core
2024
Highlights•IRF8+ cDC1, IRF4+ cDC2, moDCs, and macrophages are the APCs of murine heart•Self-antigen presentation in steady state drives Treg development via cDC1s•Myocardial infarction promotes infiltration, activation, maturation all DCs•Myocardial priming Th1/Th17 autoreactive T cells cDC2sSummaryPeripheral tolerance is crucial for avoiding activation self-reactive to tissue-restricted antigens. Sterile tissue injury can break peripheral tolerance, but it unclear how get activated response...
In rare instances, pediatric SARS-CoV-2 infection results in a novel immunodysregulation syndrome termed multisystem inflammatory children (MIS-C). We compared MIS-C immunopathology with severe COVID-19 adults. does not result pneumocyte damage but is associated vascular endotheliitis and gastrointestinal epithelial injury. MIS-C, the cytokine release characterized by IFNγ type I interferon. Persistence of patrolling monocytes differentiates from COVID-19, which dominated HLA-DRlo classical...
Asthma is characterized by lung eosinophilia, remodeling, and mucus plugging, controlled adaptive Th2 effector cells secreting IL-4, IL-5, IL-13. Inhaled house dust mite (HDM) causes the release of barrier epithelial cytokines that activate various innate immune like DCs basophils can promote immunity directly or indirectly. Here, we show play a crucial role in development type 2 eosinophilic inflammation, production, bronchial hyperreactivity response to HDM inhalation C57Bl/6 mice....
Targeting immunomodulatory pathways has ushered a new era in lung cancer therapy. Further progress requires deeper insights into the biology of immune cells micro-environment.Dendritic (DCs) represent heterogeneous and highly plastic cell system with central role controlling responses. The intratumoral infiltration activation status DCs are emerging as clinically relevant parameters cancer.In this study, we used an orthotopic preclinical model to dissect how tumor micro-environment affects...
The Adjuvant System AS01 contains monophosphoryl lipid A (MPL) and the saponin QS-21 in a liposomal formulation. is included recently developed vaccines against malaria varicella zoster virus. Like for many other adjuvants, induction of adaptive immunity by highly dependent on ability to recruit activate dendritic cells (DCs) that migrate draining lymph node T B cell stimulation. objective this study was more precisely address contribution different conventional (cDC) monocyte-derived DC...
Significance Dendritic cells (DC) play a crucial role in the immune system by bridging innate and adaptive immunity. In spleen, specific subset of DCs accumulates around blood-filtering marginal zone to capture particulate antigens such as red blood cells. We show here that these specialized develop response NOTCH2 instruction is regulated poorly studied kinase, called Thousand One Kinase 3 (TAOK3). This kinase controls DC development cell-intrinsic manner, rendering receptive signaling....
The ubiquitin-editing enzyme A20 is a well-known regulator of immune cell function and homeostasis. In addition, protects cells from death in an ill-defined manner. While most studies focus on its role the TNF-receptor complex, we here identify novel component A20-mediated decision between life death. Loss NK led to spontaneous severe lymphopenia. few remaining showed immature, hyperactivated phenotype, hallmarked by basal release cytokines cytotoxic molecules. NK-A20−/− were hypersensitive...
Abstract Currently circulating SARS-CoV-2 variants have gained complete or significant resistance to all SARS-CoV-2-neutralizing antibodies that been used in the clinic. Such can prevent severe disease exposed patients for whom vaccines may not provide optimal protection. Here, we describe single-domain (VHHs), also known as nanobodies, broadly neutralize with unusually high potency. Structural analysis revealed their binding a unique, highly conserved, membrane proximal, quaternary epitope...
Pneumonia virus of mice (PVM) infection has been widely used as a rodent model to study the closely related human respiratory syncytial (hRSV). While T cells are indispensable for viral clearance, they also contribute immunopathology. To gain more insight into mechanistic details, novel tools needed that allow virus-specific in C57BL/6 majority transgenic only available on this background. PVM-specific CD8 cell epitopes were recently described, so far no CD4 have identified within strain....
Healthy adipose tissue (AT) contains ST2+ Tregs, ILC2s, and alternatively activated macrophages that are lost in mice or humans on high caloric diet. Understanding how this form of type 2 immunity is regulated could improve treatment obesity. The STE20 kinase Thousand And One amino acid Kinase-3 (TAOK3) has been linked to obesity humans, but its precise function unknown. We found Tregs upregulated visceral epididymal white AT (eWAT) Taok3−/− mice, dependent IL-33 the activity TAOK3. Upon fat...
Since the precursor frequency of naïve T cells is extremely low, investigating early steps antigen-specific cell activation challenging. To overcome this detection problem, adoptive transfer a cohort purified from receptor (TCR) transgenic donors has been extensively used but not readily available for emerging pathogens. Constructing TCR mice hybridomas labor-intensive and sometimes erratic process, since best clones are selected based on antigen-induced CD69 upregulation or IL-2 production...
ABSTRACT Since the precursor frequency of naïve T cells is extremely low, investigating early steps antigen-specific cell activation challenging. To overcome this detection problem, adoptive transfer a cohort purified from receptor (TCR) transgenic donors has been extensively used but not readily available for emerging pathogens. Constructing TCR mice hybridomas labor-intensive and sometimes erratic process, since best clones are selected based on antigen-induced CD69 upregulation or IL-2...