A5100676243- Healthcare and Venom Research
- Food Quality and Safety Studies
- Pharmacological Effects of Natural Compounds
- Statistical Methods in Clinical Trials
- Biosimilars and Bioanalytical Methods
- Traditional Chinese Medicine Studies
- Dementia and Cognitive Impairment Research
- Ginseng Biological Effects and Applications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutrition and Health in Aging
- Plant-based Medicinal Research
- Alzheimer's disease research and treatments
- Optimal Experimental Design Methods
- Spinal Hematomas and Complications
- Sleep and Work-Related Fatigue
- Infant Health and Development
- Chromatography in Natural Products
- Workplace Health and Well-being
- Magnolia and Illicium research
- Cardiovascular Health and Risk Factors
- Heat shock proteins research
- Exercise and Physiological Responses
- Stress Responses and Cortisol
- Chronic Disease Management Strategies
- Health disparities and outcomes
Yonsei University
2017-2021
Ulsan National Institute of Science and Technology
2020
University of Pittsburgh
2019
Friedreich's Ataxia Research Alliance
2019
Children's Hospital of Philadelphia
2019
University of Pennsylvania
2019
Banner Sun Health Research Institute
2013
Gachon University
2013
Asan Medical Center
2010
Friedreich ataxia (FRDA) is a progressive neuro- and cardio-degenerative disorder characterized by ataxia, sensory loss, hypertrophic cardiomyopathy. In most cases, the caused GAA repeat expansions in first introns of both alleles <i>FXN</i> gene, resulting decreased expression encoded protein, frataxin. Frataxin localizes to mitochondrial matrix required for iron-sulfur-cluster biosynthesis. Decreased frataxin associated with dysfunction, iron accumulation, increased oxidative stress....
We recently discovered elevated β-secretase 1 (BACE1) activity in brains with sporadic Alzheimer disease (AD). Moreover, we also found high levels of BACE1 enzymatic the cerebrospinal fluid from patients both mild cognitive impairment (MCI) and AD. These results suggest that elevation may occur early or contribute to therefore examined whether was changed MCI brains. tumor necrosis factor (TNF)-α were measured by assay ELISA temporal cortex 18 clinically well-characterized AD, MCI, healthy...
To determine the effects of sleep parameters and fatigue on decline in alertness nurses across shifts.Shift work can lead to nurse owing insufficient inadequate recovery time between shifts. Nurse has adverse affect provision quality care.An observational study using wrist actigraphs was conducted from 2019 2020. Participants were 82 rotating-shift who provided direct nursing care acute hospitals South Korea. They wore for 14 days measure predict hourly reported subjective before after every...
Alzheimer's disease (AD) is a complex, age-related neurodegenerative that the most common form of dementia. However, cure for AD has not yet been founded. The accumulation amyloid beta (Aβ) considered to be hallmark AD. Beta-site precursor protein cleaving enzyme 1 (BACE1), also known as secretase initiating in amyloidogenic pathway. Blocking BACE1 could reduce amount Aβ, but this would prohibit other functions brain physiological activity. SPONDIN1 (SPON1) bind binding site (APP) and blocks...
The goal of this study was to analyze the relationship between exercise frequency and all-cause mortality for individuals diagnosed with without diabetes mellitus (DM).We analyzed data 505,677 participants (53.9% men) in National Health Insurance Service-National Screening (NHIS-HEALS) cohort. endpoint variable mortality.Frequency covariates including age, sex, smoking status, household income, blood pressure, fasting glucose, body mass index, total cholesterol, Charlson comorbidity index...
Abstract Aim To examine the effects of diabetes, low income and their combination on mortality in Korean population. Methods We analysed a total 505 677 people (53.9% male) aged 40–79 years old from National Health Insurance Service‐National Screening ( NHIS ‐ HEALS ) cohort. Ten levels household were used as indicators economic status. Diabetes was defined elevated fasting blood glucose (≥ 6.9 mmol/l) and/or use glucose‐lowering drugs or insulin. Covariates age, sex, BMI , smoking Charlson...
ABSTRACT This study aims to investigate the readmission rates of major disease groups as stated by Centers for Medicare and Medicaid Services identify risk factors related in Korea. We studied 2,973 patients discharged from a 2,200-bed tertiary referral hospital South Korea, April 1, 2016, March 31, 2017. Using electronic medical records, we calculated 30-day seven diseases: acute myocardial infarction, chronic obstructive pulmonary (COPD), heart failure (HF), pneumonia, stroke, coronary...
Objectives : Investigation of the antidepressant effect Glycyrrhizae Radix (GR) through anti-inflammatory effect. Methods Depression in rats was induced by LPS (i,p.3days). The were treated with GR100 mg/kg (GR 100) or GR400 400). depressive immobility examined Tail Suspension Test(TST) and Forced Swimming Test(FST). expression nuclear factor-<TEX>${\kappa}B$</TEX>(NF-<TEX>${\kappa}B)$</TEX>, <TEX>$I{\kappa}B$</TEX> measured western blotting. concentration corticosterone, cytokine plasma...
Objectives : The aim of this study was to evaluate the efficacy Hwangnyeonhaedok-tang (HH) and Geongangbuja-tang (GB) on plasma hormone level in mice exposed cold stress. HH GB are representative prescriptions hot property, respectively. Methods We established condition by confining ICR a <TEX>$4^{\circ}C$</TEX> cage for 24 hours, were given (100, 300, 1000 mg/kg) or extract orally twice day three consecutive days. From second day, they stress (<TEX>$4^{\circ}C$</TEX>) twenty four hours. To...
Despite increasing enrollment in long-term care (LTC) insurance Korea, it is not known whether has improved patient outcomes different settings. The aim of this study was to compare physical function among older individuals with dementia day (DC) those home (HC) A retrospective, matched cohort design adopted using the LTC data set from National Health Insurance Service Korea. total 7,822 adults who received either DC or HC consistently for 1 year were identified. Higher scores activities...
The goal of this study was to analyze the relationship between exercise frequency and all-cause mortality for individuals diagnosed with without diabetes mellitus (DM). We analyzed data 505,677 participants (53.9% men) in National Health Insurance Service - Screening (NHIS-HEALS) cohort. endpoint variable mortality. Frequency covariates including age, sex, smoking status, household income, blood pressure, fasting glucose, body mass index, total cholesterol, Charlson Comorbidity Index were...