A5019949785- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Fetal and Pediatric Neurological Disorders
- Epigenetics and DNA Methylation
- Obesity, Physical Activity, Diet
- Genomic variations and chromosomal abnormalities
- Vitamin D Research Studies
- Uterine Myomas and Treatments
- RNA modifications and cancer
- Bariatric Surgery and Outcomes
- Vascular Procedures and Complications
- Gynecological conditions and treatments
- Pregnancy-related medical research
- Cardiovascular Issues in Pregnancy
- Video Surveillance and Tracking Methods
- Ectopic Pregnancy Diagnosis and Management
- Fatty Acid Research and Health
- Preterm Birth and Chorioamnionitis
- Anomaly Detection Techniques and Applications
- Technology and Security Systems
- Female Genital Mutilation/Cutting Issues
- Rough Sets and Fuzzy Logic
- Medical Research and Treatments
Women's Hospital, School of Medicine, Zhejiang University
2007-2025
Hangzhou Medical College
2024-2025
Zhejiang Provincial People's Hospital
2024-2025
Hangzhou Women’s Hospital
2019-2024
Affiliated Hospital of Hangzhou Normal University
2021-2024
Zhejiang Chinese Medical University
2021-2023
Hangzhou Normal University
2022-2023
Hangzhou First People's Hospital
2020-2023
National Health and Family Planning Commission
2014
Institute of Geographic Sciences and Natural Resources Research
2012-2013
The air quality in China, particularly the PM2.5 (particles less than 2.5 μm aerodynamic diameter) level, has become an increasing public concern because of its relation to health risks. distribution concentrations a close relationship with multiple geographic and socioeconomic factors, but lack reliable data been main obstacle studying this topic. Based on newly published Annual Average gridded data, together land use population Gross Domestic Product (GDP) paper explored spatial-temporal...
A fundamental requirement for effective automated analysis of object behavior and interactions in video is that each must be consistently identified over time. This difficult when the objects are often occluded long periods: nearly all tracking algorithms will terminate a track with loss identity on gap. The problem further confounded by close proximity, failures due to shadows, etc. Recently, some work has been done address these issues using higher level reasoning, linking tracks from...
Identification of protein quantitative trait loci (pQTL) helps understand the underlying mechanisms diseases and discover promising targets for pharmacological intervention. For most important class drug targets, genetic evidence needs to be generalizable diverse populations. Given that majority previous studies were conducted in European ancestry populations, little is known about protein-associated variants East Asians. Based on data-independent acquisition mass spectrometry technique, we...
Continuous glucose monitoring (CGM) has shown potential in improving maternal and neonatal outcomes individuals with type 1/2 diabetes, but data gestational diabetes mellitus (GDM) is limited. We aimed to explore the relationship between CGM-derived metrics during pregnancy among women GDM.We recruited 1302 pregnant GDM at a mean age of 26.0 weeks followed them until delivery. Participants underwent 14-day CGM measurement upon recruitment. The primary outcome was any adverse outcome, defined...
Abstract Objectives . To characterise the changes in serum visfatin levels late normal pregnancy and pre‐eclampsia. Methods Twenty‐seven women with pre‐eclampsia were recruited. Twenty‐eight third trimester of served as pregnant control 28 healthy non‐pregnant control. Serum measured an enzyme‐linked immunosorbent assay. Results The means 626.4±45.5ng/ml (mean±SEM) control, 695.9±92.5ng/ml 308.3±80.0 ng/ml pre‐eclampsia, respectively, significantly different among groups ( p <0.001)....
Objective: Vitamin D deficiency and insufficiency in children are global public health problems. However, few studies have focused on vitamin status healthy preschool children, especially Asia. This study aimed to investigate host-related factors Hangzhou analyze the impact of low levels (&lt;30 ng/mL) outcomes (obesity, early childhood caries, respiratory tract infections). Methods: A total 1,510 aged 24–72 months from 15 kindergartens were included. Data children's gender, age, body...
Abstract Background Gestational diabetes mellitus (GDM) is a common pregnancy-specific disease and growing at an alarming rate worldwide, which can negatively affect the health of pregnant women fetuses. However, most studies are limited to one tissue, placenta or umbilical cord blood, usually with omics assay. It thus difficult systematically reveal molecular mechanism GDM key influencing factors on offspring. Results We recruited group 21 20 controls without GDM. For each woman, reduced...
Benchmark datasets normally have relatively conserved relationships and low fraction of outliers, indicated from higher determination coefficient (R2) lower Mean Absolute Error (MAE) in regression model. Here inspired by the process peeling onions, we introduced a recursive data elimination (RDE) "outliers" strategy to get benchmark dataset. Outliers are labeled using William's plot residual vs leverage (recorded as RDE_W), performance was compared with that alone RDE). The validation...
Both mothers and infants experience oxidative stress due to gestational diabetes mellitus (GDM), which is strongly associated with adverse pregnancy outcomes. Ferroptosis, a novel form of programmed cell death characterized by iron-dependent lipid peroxidation, believed play critical role in the pathogenesis progression GDM. Metformin (MET) has shown potential alleviating stress; however, research on its specific mechanisms action GDM remains limited. We collected placental tissues from...
Hemorrhagic fever with renal syndrome (HFRS) is an important public health problem in China. The identification of the spatiotemporal pattern HFRS will provide a foundation for effective control disease. Based on incidence HFRS, as well environmental factors, and social-economic factors China from 2005–2012, this paper identified characteristics distribution that impact distribution. results indicate spatial had significant, positive correlation. heterogeneity was affected by temperature,...
We established a prospective birth cohort, the Westlake Precision Birth Cohort (WeBirth), based on 2000 pregnant women with gestational diabetes mellitus (GDM) in second trimester and their offspring. The WeBirth provides new framework for cohort study sophisticated integration of precision nutrition, wearable devices, multiomics data collection among patients GDM. Gestational is common pregnancy complication, its prevalence has been increasing worldwide [1]. Specifically, GDM exceeded 20%...
Abstract Background The early life risk factors of childhood obesity among preterm infants are unclear and little is known about the influence feeding practices. We aimed to identify for overweight/obesity determine practices that could modify identified factors. Methods A total 338,413 mother-child pairs were enrolled in Jiaxing Birth Cohort (1999 2013), 2125 eligible singleton born children included analyses. obtained data on health examination, anthropometric measurement, lifestyle,...
Globally, the preterm birth rate has tended to increase over time. Ultrasonography cervical-length assessment is considered be most effective screening method for birth, but routine, universal remains controversial because of its cost.We used obstetric data analyze and assess risk birth. A machine learning model based on time-series technology was regular, repeated examination records during pregnancy improve performance model.This study attempts use continuous electronic medical record...
Aim To analyse the management strategies and delivery outcomes of women with cervical leiomyomas in pregnancy. Methods We retrospectively analysed pregnancy 17 leiomyomas. The outcome measures assessed included volume blood loss at delivery, need for transfusion, intra‐ post‐operative complications length hospital stay. Results mean diameter was 10.4 ± 7.2 cm, a range 3–30 cm. 697 394 mL (range 350–4200 ). Six (35.3%) required transfusion. duration stay after 7.9 3.9 days 4–20 days). There...
Understanding the influence of temperature on hand-foot-and-mouth disease (HFMD) is an important public health concern as well being a major climate-infection issue in mainland China. City-scale data incidence rates (IRs) HFMD and from 2008 to 2009 China has been analyzed. There were two peak periods for prevalence April July August November. Regions with higher monthly IR periodically shifted following pattern south–north–south March December. Monthly at city scale closely associated both...
Preeclampsia reduces placental expression and activity of 11β-hydroxysteroid dehydrogenase type 2 (HSD11B2), leading to an increase in fetal glucocordicoids. The latter has been proposed be associated with low birth weight high risk metabolic diseases later life the offspring. This investigation aims delineate alteration methylation levels at CpG sites HSD11B2 promoter.Methylation HSD9-2, HSD9-3, HSD23-2 HSD23-3 mean level were significantly lower preeclampsia than normal pregnancy (P =...
To investigate the clinical significance of prenatal diagnosis and prognosis evaluation congenital choledochal cyst (CCC), we reviewed CCC cases diagnosed antenatally in our hospital from 2007 to 2013, summarised analysed sonographic features outcomes, followed these up six months after birth. We found that induced labour was conducted 7 cases, term progressed smoothly 14 among 21 cases. Operations were completed within 3 birth all operation received a good prognosis. suggest is one kind...
Studies have demonstrated the associations between pre-pregnancy obesity, thyroid dysfunction, dyslipidemia, and increased risk of gestational diabetes mellitus (GDM) in pregnant women. This study was designed to investigate whether what extent, interactions these factors contribute GDM.A case-control 232 GDM cases 696 controls conducted among women from Hangzhou, China. Multiple logistic regression analysis applied identify independent GDM. Crossover performed assess interactive effects...
Microbiome epidemiology is an emerging field for the discovery of novel disease biomarkers or intervention targets in human epidemiological studies. The determinants and consequences microbiome variations, especially gut microbiome, are both important unsolved research questions, while majority findings prior based on small-scale studies with limited statistical power a lack replication/generalizability across different populations. Here, we initiated Westlake Gut (WeGut) project, consortium...
Increasing epidemiological studies have confirmed the association between maternal preeclampsia and elevated blood pressure in their offspring. Though case-control or cohort demonstrated long-term outcomes for offspring of preeclampsia, it is still a question that how these changes were caused by genetic reasons itself.In our study, we explored potential epigenetic regulation delta-like homolog 1-maternally expressed gene 3 (DLK1-MEG3) region human umbilical vein endothelial cells (HUVECs),...