A5100751873- Birth, Development, and Health
- Gut microbiota and health
- Diet and metabolism studies
- Heusler alloys: electronic and magnetic properties
- Gestational Diabetes Research and Management
- Physics of Superconductivity and Magnetism
- MicroRNA in disease regulation
- FOXO transcription factor regulation
- ZnO doping and properties
- Quantum many-body systems
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Ultrasound and Hyperthermia Applications
- Diet, Metabolism, and Disease
- Topological Materials and Phenomena
- Semiconductor materials and interfaces
- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA modifications and cancer
- Chronic Lymphocytic Leukemia Research
- Circadian rhythm and melatonin
- Cancer, Stress, Anesthesia, and Immune Response
- Potassium and Related Disorders
- Metabolism, Diabetes, and Cancer
- Advanced Condensed Matter Physics
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Peking Union Medical College Hospital
2020-2025
Xi'an Jiaotong University
2014-2024
Changchun University of Chinese Medicine
2021-2024
Xinjiang Medical University
2017-2023
Chongqing Three Gorges University
2020-2022
Fifth Affiliated Hospital of Xinjiang Medical University
2017-2021
Nanchang University
2015-2021
First Affiliated Hospital of Nanchang University
2015-2021
ShenZhen People’s Hospital
2015-2019
Abstract Background Abnormal blood potassium levels are associated with an increased risk of cardiometabolic diseases and mortality in the general population; however, evidence regarding association between dyskalemia among patients cardiovascular disease (CVD) remains inconclusive. This study aimed to evaluate all-cause CVD. Methods PubMed, Embase, Web Science, Cochrane Library databases were searched up August 2023 identify relevant cohort studies CVD, such as myocardial infarction,...
Qimai Feiluoping decoction (QM), a Traditional Chinese Medicine formula, has been included in rehabilitation program for functional disorders of discharged COVID-19 patients. QM proved to effectively improve the clinical symptoms and imaging signs PF convalescent patients.This study explore pharmacological effect against from perspectives imaging, pathological staining, molecular mechanisms, identify possible active components.Micro-CT immunohistochemical staining were investigated verify...
Using the full potential linearized augment plane wave method with modified Becke and Johnson (mBJ) potential, half-metallicity electronic structure for wurtzite ScM (M = C, Si, Ge, Sn) compounds are investigated. The series found to be excellent half-metallic ferromagnets (HMFs) large gaps (0.76–0.33 eV). magnetic moments 2.00 μB per cell, p-d hybridization mechanism plays crucial role in forming ferromagnetism. ferromagnetic ground states, larger half metallic gaps, robust respect lattice...
The chromobox protein homolog 7 (CBX7), one member of the polycomb group family, has been characterized mainly to play a tumor-suppressive role in human malignant neoplasias. Moreover, downregulation CBX7 is correlated with poor prognosis and aggressiveness variety cancers. However, biological functions cervical cancer have not elucidated. In present study, we explore whether exerts its function cancer. To achieve this goal, molecular approaches were used upregulate expression or cell lines....
The prevalence of gestational obesity has reached epidemic proportions. Evidence supported that the interactions between gut microbiota and circadian clocks far reached, affecting host metabolism. Our study aimed to investigate effect a high-fat diet (HF) on hepatic adipose rhythms in mice explore role microbiota-derived short-chain fatty acids (SCFAs) mediating effects. C57BL/6 female were randomly fed standard chow (Ctr) or HF prior during pregnancy. Samples collected every 4 h over 24...
Osteosarcoma (OS), a common worldwide primary aggressive bone malignancy, arises from primitive transformed cells of mesenchymal origin and usually attacks adolescents young adults. Methotrexate (MTX) is the anti-folate drug used as pivotal chemotherapeutic agent in treatment OS. However, patients with OS often develop resistance, leading to poor outcomes. In present study, order explore underlying mechanisms responsible for MTX we established MTX‑resistant using U2OS MG63 cell lines...
Using the full potential linearized augment plane wave method with generalized gradient approximation (GGA) and GGA plus modified Becke Johnson (GGA+mBJ) potential, electronic structures ferromagnetism for boron doped bulk surface CdSe are investigated. Calculations show that substitutional selenium in could induce spin polarized localized states gap generate local magnetic moments 3.00 μB one dopant atom. Energy difference between antiferromagnetic ferromagnetic phase suggests BSe favors...
The inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene not only results in initiation, but also mediates metastasis. However, mechanisms by which VHL leads to metastasis have yet been well defined. In this study, silencing 3AO and SKOV3 ovarian cancer cells was found promote cell motility increase expression matrix metalloproteinase (MMP)2, MMP9, hypoxia-inducible factor 1-α (HIF-1α) microRNA (miR)-210. suppression HIF-1α with its inhibitor...
Early life is a critical window for preventing the intergenerational transmission of metabolic diseases. Betaine has been proven to play role in improving glucose and lipid metabolism disorders animal models. However, whether maternal betaine supplementation plays regulating gut microbiota both dams offspring remains unclear. In this study, C57BL/6 female mice were fed with control diet (Ctr), high-fat (HF), (0.3% diet, HFB) from 3 weeks prior mating lasted throughout pregnancy lactation....
Background: The bone marrow microenvironment constitutes a sanctuary for leukemia cells. Recent evidence indicates that environment-mediated drug resistance arises from reciprocal influence between tumor cells and the surrounding stroma. present study aimed to investigate effect of chronic lymphocytic (CLL) on metabolism stroma, determine role this metabolic change in stroma vorinostat CLL cells, thus assess novel strategy target achieve maximum therapeutic vorinostat. Methods: To evaluate...
Skp2 (S-phase kinase-associated protein 2) plays an oncogenic role in a variety of human cancers. However, the function osteosarcoma (OS) is elusive. Therefore, current study, we explore whether exerts its OS. The cell growth, apoptosis, invasion and cycle were measured OS cells after overexpression. We found that overexpression enhanced inhibited apoptosis cells. Moreover, observed upregulation accelerated progression Furthermore, ability migration was overexpressing Mechanically, our...
Metformin and pioglitazone monotherapy have been proven to alter gut microbiota in diabetes obesity. The present study aimed investigated whether the combined administration of metformin achieved superior protective effects on high-fat diet (HFD)-fed obese mice elucidated its molecular mechanism via metabolites. C57BL/6 males were randomly divided into five groups: control group, fed a normal diet; HFD an HFD; treated with metformin; pioglitazone; combination therapy therapy. cecal contents...
Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia, and currently incurable due to drug resistance. A previous study indicated that redox interaction between bone marrow stromal cells profoundly affected CLL cell viability response. The present aimed further investigate effect on resistance in microenvironment, assess a novel redox-mediated strategy eliminate stromal-protected cells, thus achieve maximum therapeutic efficacy antileukemic drugs. Histone deacetylase...
Abstract Scope: Circadian rhythms profoundly impact metabolism and the gut microbiota. A maternal high‐fat diet (HFD) exerts effects on metabolic syndrome of adult offspring in a sex‐specific manner, underlying mechanisms, however, remain unclear. Methods results: Female mice are fed an HFD raise their standard chow until 24 weeks. The glucose tolerance, insulin sensitivity, diurnal serum profiles assessed male female offspring. Simultaneously, 16S rRNA is applied to characterize microbiota...