A5050687098- Microbial Natural Products and Biosynthesis
- Metabolomics and Mass Spectrometry Studies
- Marine Sponges and Natural Products
- COVID-19 Clinical Research Studies
- Spectroscopy and Quantum Chemical Studies
- Quinazolinone synthesis and applications
- Cardiovascular and exercise physiology
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Phenothiazines and Benzothiazines Synthesis and Activities
- Analytical Chemistry and Chromatography
- Molecular spectroscopy and chirality
- Synthesis and bioactivity of alkaloids
- Natural product bioactivities and synthesis
- Heart Rate Variability and Autonomic Control
- Plant chemical constituents analysis
- Liver Diseases and Immunity
- Tryptophan and brain disorders
- Diet and metabolism studies
- Carbohydrate Chemistry and Synthesis
- Bioactive Compounds and Antitumor Agents
- Muscle metabolism and nutrition
Universidade Federal de São Carlos
2018-2024
Ruhr University Bochum
2019
Abstract The aging process causes changes at all organic levels. Although metabolism, cardiac autonomic modulation (CAM), and cardiorespiratory fitness (CRF) are widely studied as a function of age, they mainly in isolation, thus making it difficult to perceive their concomitant variations. This study aimed investigate the integrated that occur metabolome, CAM, CRF throughout apparently healthy individuals. subjects (n = 118) were divided into five groups according age (20–29, 30–39, 40–49,...
Aging process is characterized by a progressive decline of several organic, physiological, and metabolic functions whose precise mechanism remains unclear. Metabolomics allows the identification metabolites may contribute to clarifying aging-regulated pathways. We aimed investigate aging-related serum changes using metabolomics approach. Fasting blood samples from 138 apparently healthy individuals (20−70 years old, 56% men) were analyzed Proton Nuclear Magnetic Resonance spectroscopy (1H...
Strong solute-solvent interactions have been shown to a significant influence on the vibrational circular dichroism (VCD) spectral signatures of chiral solutes. In order use VCD spectroscopy determine absolute configurations, these intermolecular thus need be accounted for in spectra simulations. For hydrogen bond donating functional groups such as carboxylic acids or hydroxy groups, it has that micro-solvation with single solvent molecule is usually sufficient model effect spectra. case...
A new method of screening was developed to generate 770 organic and water-soluble fractions from extracts nine species marine sponges, the growth media 18 marine-derived fungi, 13 endophytic fungi. The results indicated that displayed significant bioactivity in cytotoxic, antibiotic, anti-Leishmania, anti-Trypanosoma cruzi, inhibition proteasome assays. Purification medium Penicillium solitum IS1-A provided glutamic acid derivatives solitumine (1), B (2), solitumidines A–D (3–6). structures...
<title>Abstract</title> Introduction Primary Biliary Cholangitis (PBC) is a rare disease that affects the liver. It causes progressive destruction of intrahepatic bile ducts, leading to liver fibrosis. Currently, diagnosis PBC includes medical and family history, physical exams, blood tests, imaging occasionally biopsy. If not promptly treated, progresses cirrhosis, failure, death. Objectives To improve development new diagnostic or prognostic methods for PBC, metabolomic-based study was...
Concerns about the SARS-CoV-2 outbreak (COVID-19) continue to persist even years later, with emergence of new variants and risk disease severity. Common clinical symptoms, like cough, fever, respiratory characterize noncritical patients, classifying them from mild moderate. In a more severe complex scenario, virus infection can affect vital organs, resulting, for instance, in pneumonia impaired kidney heart function. However, it is well-known that subclinical symptoms at metabolic level be...
In recent decades, fungi-derived naturally occurring quinazolines have emerged as potential drug candidates. Nevertheless, most studies are conducted for bioactivity assays, and little is known about their absorption, distribution, metabolism, elimination (ADME) properties. To perform metabolic studies, the synthesis of quinazolinone, fiscalin B (