A5100637512- HIV Research and Treatment
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Hepatitis B Virus Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- Hepatitis C virus research
- Psoriasis: Treatment and Pathogenesis
- Liver Disease Diagnosis and Treatment
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Noise Effects and Management
- Peripheral Neuropathies and Disorders
- Brucella: diagnosis, epidemiology, treatment
- Traditional Chinese Medicine Analysis
- Health, Environment, Cognitive Aging
- Traditional Chinese Medicine Studies
- Bacteriophages and microbial interactions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Herpesvirus Infections and Treatments
- Virus-based gene therapy research
- Apelin-related biomedical research
- Galectins and Cancer Biology
- Parasites and Host Interactions
Shandong Provincial QianFoShan Hospital
2024
Shandong First Medical University
2024
Beijing Ditan Hospital
2021
Capital Medical University
2021
Peking University First Hospital
2016-2021
Peking University
2016-2021
Second Affiliated Hospital of Nanjing Medical University
2020
Nanjing Medical University
2020
People's Hospital of Cangzhou
2016-2019
Baoding People's Hospital
2019
Interleukin-17 (IL-17), a pleiotropic cytokine, plays significant role in the inflammatory diseases. By pilot study with small population, IL-17 polymorphisms (IL-17A rs2275913 and IL-17F rs763780) showed more potential risk factor knee osteoarthritis (OA) our recruited subjects. In current study, association between IL-17A rs763780and of OA Chinese population is studied.The rs763780 were determined 594 cases 576 healthy controls, using polymerase chain reaction-restriction fragment length...
The effects of near-road pollution on lung function in China have not been well studied. We aimed to investigate the long-term exposure traffic-related air function, airway inflammation, and respiratory symptoms.We enrolled 1003 residents aged 57.96 ± 8.99 years living Shichahai Community Beijing. Distances between home addresses nearest major roads were measured calculate home-road distance. used distance categories 1, 2, 3, representing <100 m, 100-200 >200 respectively, as dose indicator...
The effort to develop an effective preventive vaccine against HIV-1 infection is challenged by the wide genetic diversity of among different isolates.To explore a new vaccination strategy using heterologous HIV immunogens derived from clades for sequential priming and boosting.HIV Env Gag Thailand B (B'), C/B' recombinant A/E were selected as these three account 29%, 45% 15% prevalence in China, respectively. Three humanized fusion genes env gag those synthesized inserted into DNA Tiantan...
Previous research has shown that host Cyclophilin A (CyPA) can promote dendritic cell maturation and the subsequent innate immune response when incorporated into an HIV-1 Gag protein to circumvent resistance of cells infection. This led us hypothesize CyPA may improve Gag-specific vaccine immunogenicity via binding with antigen. The adjuvant effect was evaluated using a DNA single or dual expression cassettes. Mouse studies indicated specifically markedly promoted cellular immunity but not...
Host genetic factors and environmental including hepatitis B virus (HBV) genotype are widely studied for the different outcomes of HBV infection. Human leukocyte antigen (HLA) plays an important role in immunological reaction to infection.To explore whether HLA-DQB1 allele polymorphisms associated with outcome infection a Chinese Han population.One hundred thirty three subjects spontaneous recovery 151 chronic patients were recruited into this case-control study Beijing area China.Sequence...
A novel HLA allele, C*04:82 , was identified in a Chinese individual, which has nine nucleotides insertion compared with the closest matching allele HLA‐C*04:01:01 exon 5, resulting three amino acid insertions: 301 Ala, 302 Val and 303 Leu.
Pattern of flow-volume (F-V) loop in unilateral main bronchus obstruction (UMBO) is under-represented and sometimes misinterpreted as chronic obstructive pulmonary disease (COPD).A cross-sectional study was performed among patients with UMBO COPD confirmed by bronchoscopy, radiographic imaging spirometry from 2006 to 2019. Data were extracted electronic medical records. Spirometry data curves (F-V curves) analyzed. Expiratory F-V curve classified monophasic or biphasic according the absence...
CD4+ T cells play a critical role in the regulation of immunopathogenesis HIV infection. Previous studies have shown contradictory results T-cell responses people living with (PLHIV).A cross-sectional study was performed on 40 healthy controls, 134 ART-naïve PLHIV, and 34 individuals who experienced 3-year ART low baseline CD4 count from 4 August 2016 to 23 January 2019. We determined frequencies subsets described cytokine secretion pattern total these individuals.We found that PLHIV...
Objective To test single nucleotide polymorphisms (SNP) of IL-17A G-197A and IL-17F T7488C in the Chinese Han nationality population analyze association SNP with susceptibility to osteoarthritis. Methods Two hundred patients primary knee OA underwent total arthroplasty 200 healthy individuals were recruited into this study from January 2008 December 2015. We obtained DNA 2 ml whole blood for (OA group) (healthy control employed a polymerase chain reaction-single strand conformation...
Objective To analyze the mucosal immune responses induced in BALB/c mice after immunization with Vaccinia Tiantan-based HIV vaccine combination protein and to evaluate efficacy of different strategies adjuvants. Methods The were intramuscularly or intranasally immunized recombinant virus Tiantan strain (rTV) carrying CN54 Gag-Pol-Env gene boosted gp140 MF59 adjuvant by intramuscular, intranasal subcutaneous injection. Serum, saliva vaginal lavage samples collected from mice. The...
Objective To explore the association between catechol-O-methyltransferase (COMT) Val158Met gene (rs4680) polymorphisms and major depressive disorder (MDD) in Han Chinese. Methods Genotypes allele frequencies of COMT were examined 250 patients 300 healthy controls by method polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). t-test, Hardy Weinberg equilibrium chi-square test used to conduct statistical analysis. Results There significant differences...
Abstract Background While increased expression of soluble CD121a (Interleukin 1 Receptor Type 1, IL-1R1) has been shown to be significantly correlated with the severity coronary artery disease (CAD), it is not yet clear whether IL-1R1 gene variants impact CAD pathogenesis. Methods The present study evaluated effects on in a Chinese-Han population; A two-stage case-control assessed 928 patients via arteriography for atherosclerosis. allele and genotype frequencies analyzed polymorphisms were...