A5003816502- HIV Research and Treatment
- Immune Cell Function and Interaction
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Influenza Virus Research Studies
- Cytomegalovirus and herpesvirus research
- Dialysis and Renal Disease Management
- T-cell and B-cell Immunology
- Central Venous Catheters and Hemodialysis
- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- HIV/AIDS drug development and treatment
- Immunodeficiency and Autoimmune Disorders
- Breast Implant and Reconstruction
- Biomedical Research and Pathophysiology
- Breast Cancer Treatment Studies
- Organ Transplantation Techniques and Outcomes
- Vascular Procedures and Complications
- Reconstructive Surgery and Microvascular Techniques
- Immune Response and Inflammation
- Respiratory viral infections research
- Cardiac Valve Diseases and Treatments
- Intestinal Malrotation and Obstruction Disorders
- Pediatric Urology and Nephrology Studies
- Immune responses and vaccinations
University of Miami
2017-2023
Dragonfly Therapeutics (United States)
2023
Johns Hopkins University Center for AIDS Research
2022
Office of AIDS Research
2021
Emory University
2021
University of Southern California
2021
Atlanta VA Medical Center
2021
Geriatric Research Education and Clinical Center
2021
University of Campania "Luigi Vanvitelli"
2020
October 6 University
2018
Objective: To determine influence of age and HIV infection on influenza vaccine responses. Design: Evaluate serologic response to seasonal trivalent (TIV) as the immunologic outcome in HIV-infected (HIV+) age-matched negative (HIV−) adults. Methods: During 2013–2016, 151 virologically controlled HIV+ individuals antiretroviral therapy 164 HIV− volunteers grouped by young (<40 years), middle aged (40–59 years) old (≥60 were administered TIV investigated for serum antibody antigens. Results:...
The present study was aimed at investigating the role of coping strategies in predicting emotional distress following breast cancer, over and above illness severity, operationalized terms type surgery performed. In order to achieve this goal, two groups newly diagnosed cancer women were selected compared on basis surgical treatment received. A subsample 30 with quadrantectomy sentinel lymph-node biopsy (SLNB) a 31 patients mastectomy axillary dissection (MAD) filled Brief Cope scale Hospital...
To analyze data on 503 chronic peritoneal dialysis (CPD) catheters implanted between 1986 and 2000 in pediatric patients enrolled the Italian Registry of Pediatric Chronic Peritoneal Dialysis (the Registry), comparing three different time periods: 1986-1990, 1991-1995, 1996-2000.Retrospective study.23 centers participating Registry.Data were collected from questionnaires filled every year. The information for each catheter included type, site technique insertion, exit-site orientation, care,...
BACKGROUND AND PURPOSE The mechanisms of paraquat (PQ)-induced toxicity are poorly understood and PQ poisoning is often fatal due to a lack effective antidotes. In this study we report the effects N-[2-(2-methoxy-6H-dipyrido{2,3-a:3,2-e}pyrrolizin-11-yl)ethyl]-2-furamide (NMDPEF), melatonin-related inhibitor quinone oxidoreductase2 (QR2) on in vitro & vivo. EXPERIMENTAL APPROACH Prevention PQ-induced was tested different cells, including primary pneumocytes astroglial U373 cells. Cell death...
Combination antiretroviral therapies (cART) can lead to normal life expectancy in HIV-infected persons, and people aged >50 yrs represent the fastest growing HIV group.Although aging are independently associated with impaired humoral immunity, immune status is relatively unexplored.In this study influenza vaccination was used probe age perturbations B cell compartment of HIV-negative "healthy controls" (HC) virologically controlled participants on cART (HIV) (n=124), grouped by as young (<40...
Biological aging is associated with immune activation (IA) and declining immunity due to systemic inflammation. It widely accepted that HIV infection causes persistent IA premature senescence despite effective antiretroviral therapy virologic suppression; however, the effects of combined are not well defined. Here, we assessed relationship between markers inflammation during biological in HIV-infected -uninfected populations. Antibody response seasonal influenza vaccination was implemented...
Antigen-primed cluster of differentiation (CD) 4+ T follicular helper (Tfh) cells interact with B in the germinal centers (GCs) lymph nodes to generate vaccine-induced antibody (Ab) responses. In circulation, peripheral Tfh (pTfh) cells, a subset memory CD4 serve as surrogates for GC because several functional and phenotypic similarities between them. We investigated features H1N1 influenza antigen-specific pTfh (Ag.pTfh) virologically controlled HIV+ volunteers on antiretroviral therapy...
2508 Background: DF1001 is a first in class, Tri-specific, NK cell Engager Therapy (TriNKET), that uses HER2 as an anchor to modulate innate and adaptive immunity. redirects both CD8 T cells reprogram the tumor microenvironment, turning cold tumors hot. DF1001-001 (NCT04143711) ongoing phase I/II, human study investigating safety, tolerability, clinical biologic activity of DF1001. The pharmacokinetic (PK), pharmacodynamic (PD) efficacy data from 1 monotherapy escalation safety/PK/PD...
Abstract HIV-infected patients of all ages frequently underperform in response to seasonal influenza vaccination, despite virologic control HIV. The molecular mechanisms governing this impairment, as well predictive biomarkers for responsiveness, remain unknown. This study was performed samples obtained prevaccination (T0) from children who received the 2012–2013 vaccine. Response status determined based on established criterion hemagglutination inhibition titer; participants with a titer...
Assays to estimate human immunodeficiency virus (HIV) reservoir size require large amounts of blood, which represents a drawback especially in pediatric settings. We investigated whether HIV-antibody repertoire could the viral size. Moreover, we assessed magnitude response as predictor time antiretroviral therapy (ART) initiation.Human virus-antibody responses 10 different proteins were evaluated by HIV Western blot (WB) kit and WB score was assigned each patient. Patients classified 2...
Abstract Early initiation of antiretroviral therapy (ART) in vertically HIV-infected children limits the size virus reservoir, but whether time treatment (TI) can durably impact host immune responses associated with HIV infection is still unknown. This study was conducted PBMC 20 virally suppressed on ART (mean age 9.4 y), classified as early treated (ET; at ≤0.5 y, n = 14) or late (LT; 1–10 6). Frequencies and functions Ag-specific CD4 (CD40L+) CD8 (CD69+) T cells were evaluated by...
HIV eradication is hindered by the existence of latent reservoirs in CD4 + T cells. Therapeutic strategies targeting cells are required to achieve a functional cure, however study latently infected from persons extremely challenging due lack biomarkers that uniquely characterize them. In this study, dual reporter virus GKO was used investigate latency establishment and maintenance lymphoid-derived Single cell technologies evaluate protein expression, host gene transcript expression were...
BackgroundDespite antiretroviral treatment (ART), immune dysfunction persists in children with perinatal HIV infection (HEI). Here we investigated the impact of status on maternal antibody (Ab) passage, long-term vaccine induced immunity and B-cell maturation.Methods46 Exposed Uninfected (HEU), 43 HEI, 15 unexposed uninfected (HUU) infants were vaccinated 3 doses DTaP-HepB-Hib-PCV10-OP at 2, 3, 4 months Matola Provincial Hospital, Maputo, Mozambique. Tetanus toxoid specific (TT) IgG, Ab...
Background: We have previously reported that an early initiation of highly active antiretroviral therapy (HAART) in HIV-1 vertically infected children enhanced the function memory B-cells gained during childhood routine vaccinations. On other hand, a significant waning immunity was observed for patients with late treatment. In this follow-up study, we report data from sample our cohort including late-treated being revaccinated vaccines. Methods: The levels serum antibodies and cellular were...
Despite effective ART, HIV-infected individuals with apparently similar clinical and immunological characteristics can vary in responsiveness to vaccinations. However, molecular mechanisms responsible for such impairment, as well biomarkers able predict vaccine HIV infected children remain unknown. Following the hypothesis that a B cell qualitative impairment persists (HIV) despite ART phenotypic immune reconstitution, aim of current study was investigate gene expression compared age-matched...
Objective To analyze the data from 347 peritoneal catheters implanted in 249 pediatric patients aged ≤ 15 years at start of chronic dialysis (CPD). Design Restrospective study collected between 1986 and 1995, 20 centers, Italian Registry Pediatric Chronic Peritoneal Dialysis. Data collection for each catheter included: type, site technique insertion, complications, duration, reason removal or replacement. Results Fifty were inserted under 2 age, 50 5 247 over age. Catheter types included 307...
The anthropometry-bioimpedance analysis-nutrition (ABN) score is a recently proposed objective method of assessing malnutrition in children on chronic peritoneal dialysis (CPD) that uses nine parameters based anthropometry, skinfold thickness and bioimpedance analysis. aim this prospective, cross-sectional study was to apply it treated with CPD seven Italian paediatric nephrology centres, < 10.33 (the 3rd percentile population 264 healthy children) classifying the as malnourished. other...
Abstract Memory B cells (MBC) respond to secondary antigen challenge protect against infection and boost immunity following vaccinations. Despite effective treatment, chronic HIV disturbs MBCs by reducing numbers altering functionality due hyper-activation increased apoptosis leading suboptimal antibody responses common infectious agents. We used single cell gene expression analysis evaluate antigen-specific memory in peripheral blood of virally-suppressed HIV-infected individuals healthy...
Objective: Antibody responses are often impaired in old age and HIV-positive (HIV+) infection despite virologic control with antiretroviral therapy but innate immunologic determinants not well understood. Design: Monocytes natural killer cells were examined for relationships to age, HIV influenza vaccine responses. Methods: Virologically suppressed HIV+ (n = 139) HIV-negative (HIV−) 137) participants classified by as young (18–39 years), middle-aged (40–59 years) (≥60 evaluated preinfluenza...