A5044701522- Cervical Cancer and HPV Research
- HIV/AIDS Research and Interventions
- Reproductive tract infections research
- Adolescent Sexual and Reproductive Health
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- HIV-related health complications and treatments
- Reproductive System and Pregnancy
- Criminal Justice and Corrections Analysis
- Statistical Methods and Bayesian Inference
- Cancer-related gene regulation
- Advanced Causal Inference Techniques
- Reproductive Health and Contraception
- Genital Health and Disease
- Pelvic floor disorders treatments
- Viral-associated cancers and disorders
- LGBTQ Health, Identity, and Policy
- Sex work and related issues
- Food Security and Health in Diverse Populations
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Statistical Methods in Epidemiology
- Pharmacological Effects and Toxicity Studies
- Statistical Methods and Inference
- Health Systems, Economic Evaluations, Quality of Life
Fraunhofer Institute for Manufacturing Engineering and Automation
2025
Georgetown University
2018-2024
Georgetown University Medical Center
2019-2023
Weatherford College
2022
Albert Einstein College of Medicine
2020
SUNY Downstate Health Sciences University
2020
Georgetown-Howard Universities Center for Clinical and Translational Science
2018-2020
Emory University
2019
University of Alabama at Birmingham
2013-2016
Virginia Tech
2014
Abstract Recent observational studies indicate an association between the use of hormonal contraceptives and acquisition transmission HIV-1. The biological immunological mechanisms underlying observed are unknown. Depot medroxyprogesterone acetate (DMPA) is a progestin-only injectable contraceptive that commonly used in regions with high HIV-1 prevalence. Here we show (MPA) suppresses production key regulators cellular humoral immunity involved orchestrating immune response to invading...
Epidemiological evidence suggests an association between the use of hormonal contraception and increased risk acquiring sexually transmitted diseases including HIV-1. We sought to elucidate biological mechanisms underlying effect on immune system.
Background: HIV-stigma can influence engagement in care and viral suppression rates among persons living with HIV (PLWH). Understanding HIV-provider level stigma its associated factors may aid development of interventions to improve care. Methods: We assessed HIV-related stigma, provider knowledge, practices beliefs healthcare providers using an online survey tool. Generalized linear modeling was used determine score. Results: Among 436 participants, the mean age 42.3 (SD 12.3), 70% female,...
Abstract Background Persistent immune activation due to gut barrier dysfunction is a suspected cause of morbidity in HIV, but the impact menopause on this pathway unknown. Methods In 350 women with HIV from Women’s Interagency Study, plasma biomarkers (intestinal fatty acid binding protein; IFAB), innate (soluble CD14 and CD163; sCD14, sCD163), systemic inflammation (interleukin-6 tumor necrosis factor receptor 1; IL-6, TNFR1) were measured at 674 person-visits spanning ≤2 years. Results...
Background: Characterizing estradiol among women with HIV may have implications for breast cancer and cardiovascular disease risk but has not been adequately explored. We quantified differences in total (E2), free (FE2) estradiol, sex hormone binding globulin (SHBG) by viral suppression status. Methods: Women from a substudy (2003-2006) within the Women's Interagency Study (IRB approved at each participating site) were included if they reported: period last six months,...
Abstract Background It is unclear whether human immunodeficiency virus (HIV) infection results in permanent loss of T-cell memory or if it affects preexisting antibodies to childhood vaccinations infections. Methods We conducted a matched cohort study involving 50 pairs HIV-infected and HIV-uninfected women. Total responses were measured after anti-CD3 vaccinia (VV) stimulation measure T cells elicited smallpox vaccination. VV-specific by means enzyme-linked immunosorbent assay (ELISA)....
Objectives. To examine whether women’s incarceration increases numbers of total and new sexual partners. Methods. US women with or at risk for HIV in a multicenter cohort study answered partner questions semiannually between 2007 2017. We used marginal structural models to compare partners visits not following all immediately incarceration. Covariates included demographics, status, sex exchange, drug alcohol use, housing instability. Results. Of the 3180 participants, 155 were incarcerated....
Causal inference methods can be applied to estimate the effect of a point exposure or treatment on an outcome interest using data from observational studies. For example, in Women's Interagency HIV Study, it is understand effects incarceration number sexual partners and cigarettes smoked after incarceration. In settings like this where count, estimand often causal mean ratio, i.e., ratio counterfactual count under no exposure. This paper considers estimators based inverse probability...
The goal of HIV treatment is viral suppression as it linked with improved health outcomes and decreased risk transmission. We assessed the sociodemographic, behavioral, patient–provider interaction associations an administered survey to HIV-seropositive women in metropolitan Washington, DC, site Women's Interagency Study (WIHS) between 2017 2018. Logistic mixed models were used explore related factors groups self-efficacy, respectively. Higher self-efficacy disclosure concerns positively...
Background: To estimate the incidence, prevalence, frequency, and duration of incarceration to identify risk factors for among women at human immunodeficiency virus (HIV) in United States. Methods: During semiannual study visits a multicenter cohort study, 970 HIV sero-negative participants were asked about their own (10/2007–09/2017) sexual partners (10/2013–09/2017). We used descriptive statistics multivariable log-binomial regression baseline predictors incident incarceration. Results:...
Trust in providers and health care systems (HCSs) has been associated with higher HIV antiretroviral (ART) adherence; however, most previous studies enrolled primarily men did not concurrently assess provider trust, HCS distrust, clinical/biological outcomes. We 239 Washington, DC Women's Interagency Study (WIHS) women: 167 (WWH) 72 without HIV. In 2006 2017–2018, women completed surveys on trust distrust. Clinical, social, demographic covariates were obtained during the 2017–2018 WIHS study...
The vaginal microbiota is known to impact women's health, but the biological factors that influence composition of are not fully understood. We previously observed levels glycogen in lumen vagina were higher women had a high body mass index (BMI). Vaginal thought microbiota. therefore sought determine if BMI was associated having or bacterial vaginosis (BV), as determined by Amsel criteria. also hypothesized increased blood glucose could lead previously-observed and investigated hemoglobin...
Abstract Background: Cervical cancer oncogenesis starts with human papillomavirus (HPV) cell entry after binding to host surface receptors; however, the mechanism is not fully known. We examined polymorphisms in receptor genes hypothesized be necessary for HPV and assessed their associations clinical progression precancer. Methods: African American women (N = 1,728) from MACS/WIHS Combined Cohort Study were included. Two case–control study designs used—cases histology-based precancer (CIN3+)...
Abstract Background Estrogen-based hormone therapy (HT) may have beneficial cardiovascular effects when initiated in early menopause. This has not been examined women with human immunodeficiency virus (HIV), who heightened immune activation and risks. Methods Among 609 postmenopausal (1234 person-visits) the Women’s Interagency HIV Study, we relationship of ever HT use (oral, patch, or vaginal) subclinical atherosclerosis: carotid artery intima-media thickness (CIMT), distensibility, plaque...
Susceptibility to metabolic diseases may be influenced by mitochondrial genetic variability among people living with human immunodeficiency virus (HIV; PLWH), but remains unexplored in populations African ancestry. We investigated the association between DNA (mtDNA) haplogroups and homeostatic model assessments of β-cell function (HOMA-B) insulin resistance (HOMA-IR), as well incident diabetes mellitus (DM), Black women or at risk for HIV.Women without DM who had fasting glucose (FG) (FI)...
During quorum sensing in the plant pathogen Pantoea stewartii subsp. stewartii, EsaI, an acyl-homoserine lactone (AHL) synthase, and transcription factor EsaR coordinately control capsular polysaccharide production. The capsule is expressed only at high cell density when AHL levels are high, leading to inactivation of EsaR. In lieu detailed structural information, precise mechanism whereby recognizes hindered by it, a response opposite that most other LuxR homologues, remains unresolved....
Background: Understanding factors associated with contraceptive use post-abortion can inform clinical practices to improve contraception uptake. Materials and Methods: This prospective cohort study included adult women who completed the survey before surgical abortion at an Atlanta, Georgia clinic, online 12 weeks later. Poisson regression models assessed associations between demographic reproductive of more effective (contraceptive pill, ring, patch, injectables, intrauterine device [IUD],...
In women with HIV, higher activation and exhaustion of CD4+ T cells were associated risk non-HIV-related mortality during a median 13.3 years follow-up, independent baseline demographic, behavioral, HIV-related, cardiometabolic factors longitudinal HIV disease progression.
To evaluate the natural history of treated and untreated cervical intraepithelial neoplasia-2 (CIN2) among HIV-positive women.
<div>Abstract<p>Background: Cervical cancer oncogenesis starts with human papillomavirus (HPV) cell entry after binding to host surface receptors; however, the mechanism is not fully known. We examined polymorphisms in receptor genes hypothesized be necessary for HPV and assessed their associations clinical progression pre-cancer. Methods: African-American women (N=1728) from MACS/WIHS Combined Cohort Study were included. Two case-control study designs used - cases...