A5102943947- RNA Research and Splicing
- RNA modifications and cancer
- Melanoma and MAPK Pathways
- Neurofibromatosis and Schwannoma Cases
- Korean Peninsula Historical and Political Studies
- Mechanisms of cancer metastasis
- Cancer Research and Treatments
- Diverse Topics in Contemporary Research
- Redox biology and oxidative stress
- TGF-β signaling in diseases
- International Law and Human Rights
- Glutathione Transferases and Polymorphisms
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Korean Urban and Social Studies
- Distributed and Parallel Computing Systems
- Regional Development and Environment
- Cancer-related molecular mechanisms research
- Nuclear Structure and Function
- Antiplatelet Therapy and Cardiovascular Diseases
- Global Peace and Security Dynamics
- Cultural and Artistic Studies
- Migration and Labor Dynamics
- Cardiac Imaging and Diagnostics
- Growth Hormone and Insulin-like Growth Factors
Medical University of South Carolina
2020-2024
Pusan National University
2015-2023
Hankuk University of Foreign Studies
2019
CHA Gangnam Medical Center
2018
CHA University
2018
Konkuk University
2013-2016
Gyeongsang National University Hospital
2008-2010
Gyeongsang National University
2009-2010
Kangwon National University
2010
Sookmyung Women's University
2006-2009
Abstract Previous work has revealed that progerin-lamin A binding inhibitor (JH4) can ameliorate pathological features of Hutchinson-Gilford progeria syndrome (HGPS) such as nuclear deformation, growth suppression in patient’s cells, and very short life span an vivo mouse model. Despite its favorable effects, JH4 is rapidly eliminated pharmacokinetic (PK) analysis. Thus, we improved property through chemical modification obtained optimized drug candidate, Progerinin (SLC-D011). This extend...
Although Argonaute (AGO) proteins have been the focus of microRNA (miRNA) studies, we observed AGO-free mature miRNAs directly interacting with RNA-binding proteins, implying sophisticated nature fine-tuning gene regulation by miRNAs. To investigate microRNA-binding (miRBPs) globally, analyzed PAR-CLIP data sets to identify RBP quaking (QKI) as a novel miRBP for let-7b. Potential existence were further verified measuring miRNA levels in genetically engineered AGO-depleted human and mouse...
Acrylamide (ACR) is a neurotoxin known to produce neurotoxicity characterized by ataxia, skeletal muscle weakness, cognitive impairment, and numbness of the extremities. Previously, investigators reported that high-dose (50 mg/kg) ACR impaired hippocampal neurogenesis increased neural progenitor cell death; however, influence subchronic environmentally relevant low dose-(2, 20, or 200 μg/kg) ACRs have not been examined in adult function mice. Accordingly, aim present study was investigate...
The aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) splice variant designated DX2 is induced by cigarette smoke carcinogens and often detected in human lung cancer specimens. However, the function of carcinogenesis obscure. In this study, we found that expression was oncogenes tissues cells. prevented oncogene-induced apoptosis senescence promoted drug resistance directly binding to inhibiting p14/ARF. Through chemical screening, identified SLCB050, a novel...
Cellular quiescence and cell cycle reentry regulate vital biological processes such as cellular development tissue homeostasis are controlled by precise regulation of gene expression. The roles long noncoding RNAs (lncRNAs) during these remain to be elucidated. By performing genome-wide transcriptome analyses, we identify differential expression several hundreds lncRNAs, including a significant number the less-characterized class microRNA-host-gene ( MIRHG ) lncRNAs or lnc- MIRHGs , in human...
Abstract Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective death of motor neurons. Mutations in Cu, Zn-superoxide dismutase (SOD1) causing the gain its toxic property are major culprit familial ALS (fALS). The abnormal SOD1 aggregation neurons has been suggested as pathological hallmark patients. However, development pharmacological interventions against still needs further investigation. In this study, using ELISA-based chemical screening...
// Jung-Hyun Cho 1 , Su-Jin Lee Ah-Young Oh Min-Ho Yoon Tae-Geun Woo and Bum-Joon Park Department of Molecular Biology, Graduated School System College Natural Science, Pusan National University, Busan Correspondence to: Park, email: Keywords : mesothelioma, p53, NF2, RKIP, Snail Received December 31, 2014 Accepted February 13, 2015 Published March 12, Abstract Although asbestos causes malignant pleural mesothelioma (MPM), rising from lung mesothelium, the molecular mechanism has not been...
Abstract Quinacrine (QNC), antiprotozoan drug commonly used against Malaria and Giardiasis, has been recently tried for rheumatics prion diseases via repositioning. In addition, several reports suggest antitumor effects of QNC through suppression NF-κB activation p53. This study demonstrates the anticancer effect a novel pathway elimination checkpoint kinase 1/2 (Chk1/2) under p53-inactivated conditions. Inhibition p53 by PFT-α or siRNA promotes QNC-induced apoptosis in normal fibroblast...
Neurofibromatosis type 2 (NF2) syndrome is a very rare human genetic disease, and there has been no proper treatment for it until now. In our recent study, reported that the loss of NF2 activates MAPK signaling through reduction RKIP in mesothelioma model. Here, we show induces TGFβ receptor (TβR2) expression, an overwhelming expression 1 (TβR1) activated by physical stimuli such as pressure or heavy materials. Activated TβR1 phosphorylation degradation RKIP. consequently results activation...
Stress has been suggested as one of important cause human cancer without molecular biological evidence. Thus, we test the effect stress-related hormones on cell viability and mitotic fidelity. Similarly to estrogen, stress hormone cortisol its relative cortisone increase microtubule organizing center (MTOC) number through elevated expression γ-tubulin provide Taxol resistance lines. However, these effects are achieved by glucocorticoid receptor (GR) but not estrogen (ER). Since ginsenosides...
Argonaute (AGO), a component of RNA-induced silencing complexes (RISCs), is representative RNA-binding protein (RBP) known to bind with mature microRNA (miRNA) and directly involved in post-transcriptional gene silencing. However, despite the biological significance miRNA, roles other micro proteins (miRBPs) remain unclear regulation miRNA loading, dissociation from RISC, extracellular release. In this study, we perform arrays profile miRBPs identify 118 binding miRNAs. Among those proteins,...
Background and Objectives : Smoking increases inhibition of clopidogrel-induced platelet reactivity in patients undergoing elective coronary stenting.However, an association between pre-admission smoking (PS) post-clopidogrel with acute myocardial infarction (AMI) has not been determined.Subjects Methods Study cohorts were recruited from a pool at our hospital who stenting for AMI (n=134).Immediately after arrival the emergency room (ER), all received 600 mg loading dose clopidogrel followed...
To prospectively evaluate the efficacy and safety of a fixed early gonadotropin-releasing hormone (GnRH) antagonist protocol compared to conventional midfollicular GnRH long agonist for in vitro fertilization (IVF) patients with polycystic ovary syndrome (PCOS).Randomized all three groups (early antagonist, n=14; n=11; agonist, n=11) received 21 days oral contraceptive pill treatment prior stimulation. The was initiated on 1st day stimulation group 6th group. 18th preceding cycle. primary...
Abstract Werner syndrome (WRN) is a rare progressive genetic disorder, caused by functional defects in WRN protein and RecQ4L DNA helicase. Acceleration of the aging process initiated at puberty expected life span approximately late 50 s. However, Wrn -deficient mouse model does not show premature phenotypes or short span, implying that processes differ greatly between humans mice. Gene expression analysis cells reveals very similar results to gene Hutchinson Gilford progeria (HGPS) cells,...