A5004582843- Cell Image Analysis Techniques
- Mosquito-borne diseases and control
- Parasite Biology and Host Interactions
- Digital Imaging for Blood Diseases
- Parasitic Diseases Research and Treatment
- Malaria Research and Control
- Nematode management and characterization studies
- Yersinia bacterium, plague, ectoparasites research
- Genetics, Bioinformatics, and Biomedical Research
- Travel-related health issues
- Parasitic Infections and Diagnostics
- Pneumonia and Respiratory Infections
- Legionella and Acanthamoeba research
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS drug development and treatment
- Vector-borne infectious diseases
- Helminth infection and control
- Vibrio bacteria research studies
National Health Laboratory Service
2017-2024
National Institute for Communicable Diseases
2021
Abstract Background Microscopic examination of Giemsa-stained blood films remains the reference standard for malaria parasite detection and quantification, but is undermined by difficulties in ensuring high-quality manual reading inter-reader reliability. Automated quantification may address this issue. Methods A multi-centre, observational study was conducted during 2018 2019 at 11 sites to assess performance EasyScan Go, a microscopy device employing machine-learning-based image analysis....
Human central nervous system infections due to free-living nematodes, although extremely rare, are usually fatal. Immunodeficiency has not been a feature of most these cases, unlike the situation pertaining disseminated Strongyloides stercoralis infection. An elderly immunocompetent man presented with history tinnitus and otalgia, progressing involvement confusion, weakness other neurological signs. Examination revealed unilateral external auditory canal soft tissue mass, radiological...
Human central nervous system infections due to free-living nematodes, although extremely rare, are usually fatal. Immunodeficiency has not been a feature of most these cases, unlike the situation pertaining disseminated Strongyloides stercoralis infection. An elderly immunocompetent man presented with history tinnitus and otalgia, progressing involvement confusion, weakness, other neurological signs. Examination revealed unilateral external auditory canal soft tissue mass radiological...
Background Pneumocystis pneumonia (PCP) is a serious risk for HIV-positive patients. Asymptomatic infection or colonisation with P. jirovecii has been shown to occur frequently. PCR assays frequently identify such cases, due their high sensitivity. Quantitative real-time (qPCR) gene copy number cut-off values have suggested differentiate and infection; these need be standardised routine use. We compared the results of qPCR an immunofluorescence assay (IFA) determine specific value. Methods...
We report the first case of Balamuthia mandrillaris granulomatous amoebic encephalitis definitively acquired in Africa. Our emphasizes initial nonspecific dermatological features, delays confirmation diagnosis, difficulties accessing recommended medication, and uncertainty about optimal treatment a disease with frequently fatal outcome.
A malaria slide bank (MSB) is a useful asset for any microscopy testing laboratory to have access to. However, it not feasible every country its own MSB. If countries are able pool their resources, regional MSB viable solution. This paper describes the methodology, costing and lessons learnt of establishing maintaining an over 3-year period, Southern Africa Development Community region.A national reference in South was granted funding setting up MSB; possessed experienced staff suitable...
Human babesiosis data in Africa is scarce. The clinical presentation and parasite morphology mimics falciparum malaria infection. Diagnostic confirmation informed by adequate history communication with the laboratory to activate appropriate testing. This case report describes course of a returning traveller persisting symptoms that resolved on tailored antimicrobial therapy following prompt collaborative diagnosis.
Cestodes of Bertiella genus are parasites nonhuman primates. We describe a rare case human bertiellosis in South Africa: 3-year-old girl with 1-year history rectal proglottid discharge and intermittent abdominal pain. After repeated failure benzimidazole antihelminthic treatment, praziquantel proved successful.