A5088771221- Blood transfusion and management
- Blood groups and transfusion
- Blood donation and transfusion practices
- Platelet Disorders and Treatments
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Computational Fluid Dynamics and Aerodynamics
- Aeroelasticity and Vibration Control
- Hematopoietic Stem Cell Transplantation
- Probabilistic and Robust Engineering Design
- Aerospace and Aviation Technology
- Structural Health Monitoring Techniques
- Erythrocyte Function and Pathophysiology
- Asthma and respiratory diseases
- Contact Dermatitis and Allergies
- Hepatitis B Virus Studies
- Wind and Air Flow Studies
- Hemoglobinopathies and Related Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hepatitis C virus research
- Dynamics and Control of Mechanical Systems
- Mesenchymal stem cell research
- Blood properties and coagulation
- Real-time simulation and control systems
- Structural Analysis and Optimization
German Red Cross
2011-2024
DRK-Blutspendedienst Baden-Württemberg - Hessen
2014-2020
Institute for Transfusion Medicine
2003-2014
University Hospital of Bern
2010
University of Eastern Finland
1998-2008
University of Alabama
1997-2006
Universitätsklinikum Gießen und Marburg
2006
Philipps University of Marburg
1994-2004
Friedrich-Alexander-Universität Erlangen-Nürnberg
2000-2003
Medizinische Hochschule Hannover
2003
A mathematical model integrating nonlinear rigid-body flight mechanics and linear aeroelastic dynamics is examined; the equations of motion for an elastic aircraft in accelerated are developed using Lagrangian mechanics. This approach used to construct a simulation F/A-18 (configured with tip missiles) which includes angular/elastic inertial coupling (IC). In general, modes significantly affected by IC were aerodynamically decoupled from rest model. The those induced changes total mass...
The three-dimensional structure of the major bovine allergen Bos d 2 has been determined by using x-ray diffraction at 1.8-Å resolution. Structurally is a member lipocalin family comprising proteins with transport functions. There flat small cavity inside protein core suitable for ligand binding, and it possible that Glu115 Asn37 are able to make hydrogen bonds ligand. Many allergens from different animals belong family. amino acid residue similarities between these lipocalins indicate...
Photodynamic virus inactivation of fresh-frozen plasma (FFP) may result in its impaired coagulation capability.Double-volume plasmapheresis samples from 11 donors were divided pairs 250 mL. One group underwent methylene blue (MB) phototreatment (MB-FFP). The other was treated according to the standards American Association Blood Banks for preparation and storage FFP. Parameters hemostasis clinically important proteins tested native plasma, thawed MB-FFP, FFP, twice-frozen FFP (FFP-II).Mean...
SARS-CoV-2 serosurveillance is important to adapt infection control measures and estimate the degree of underreporting. Blood donor samples can be used as a proxy for healthy adult population. In repeated cross-sectional study from April 2020 2021, September April/May 2022, 13 blood establishments collected 134,510 anonymised specimens donors in 28 regions across Germany. These were tested antibodies against spike protein nucleocapsid, including neutralising capacity. Seroprevalence was...
In this study we characterized the human T cell-reactive sites of major cow dander allergen, Bos d 2, a member lipocalin protein family. We showed that 2 contains only limited number epitopes. This is in contrast to many other allergens, which usually contain multiple cell epitopes throughout molecule. The were primarily concentrated conserved regions One was recognized by all cow-asthmatic individuals regardless their HLA phenotype. Computer-predicted on and endogenous lipocalins situated...
The proposed National AeroSpace Plane (NASP) is designed to travel at speeds up Mach 25. Because aerodynamic heating during high-speed flight through the atmosphere could destiffen a structure, significant couplings between elastic and rigid body modes result in lower flutter more pronounced aeroelastic response characteristics. These will also generate thermal loads on structure. purpose of this research develop methodologies applicable NASP apply them representative model determine its...
Pleiotrophin is a heparin-binding growth factor involved in the differentiation and proliferation of neuronal tissue during embryogenesis, also secreted by melanoma breast carcinoma cells. exhibits mitogenic angiogenic properties has been shown to influence vascular supply, expansion metastasis tumour Our aim was study serum plasma concentrations pleiotrophin classical endothelial factor. Using specific ELISA-test we studied patients with small cell lung cancer (n=63), non-small (n=22)...
An approach to the integration of two design activities, structural and active control design, for a highly idealized aeroservoelastic system is presented. The particular goal this study maximization stable airspeed envelope an model through rational systematic variation parameters. steady-state linear quadratic regulator used subsystem; subsystem assigned characteristic parameters, such as shear center position. application procedure described here produces optimally controlled structures...
This paper describes potential vehicle instability modes for forward swept wing aircraft and other divergence prone aircraft. Examples show that either body-freedom flutter or aeroelastic may occur depending upon the airplane planform geometry mass distribution. These instabilities at speeds very different than clamped speed.
<b><i>Background: </i></b>Upper age limits for blood donors are intended to protect elderly from donor reactions. However, due a lack of data about adverse reactions in donors, upper arbitrary and vary considerably between different countries. <b><i>Methods: </i></b>Here we present 171,231 voluntary repeat whole beyond the 68 years. <b><i>Results: </i></b>Blood donations years increased 2,114 2005 38,432 2012 (from 0,2%...
Hereditary factors may influence individual susceptibility to contact allergy.To investigate genetic variants with impacts on early inflammatory reactions and T cell functions that possibly increase the risk of allergy.Three hundred seventy two patients undergoing patch testing were recruited from Information Network Departments Dermatology (IVDK). Of these, 133 monosensitized 239 polysensitized, defined as reacting three or more unrelated sensitizers. Within polysensitized individuals, a...
BACKGROUND Due to the ageing population, blood donation by elderly is necessary maintain supply. We initiated a prospective study, assess whether there an increased risk of donor reactions in donors. STUDY DESIGN AND METHODS In this regular donors aged from 66 68 and 69 71 years were invited continue on mobile collection sites German Red Cross Blood Service West. A control group (50-52 years) was established. Admission all groups followed national guidelines for donation. Donor deferrals...
Bacterial contamination represents the major infectious hazard associated with transfusion of platelet concentrates (PCs). As bacterial screening PCs is not mandatory in Germany, BactiFlow flow cytometry test has been introduced as a rapid detection method to increase product safety.During period 25 months, total 34 631 (26 411 pooled and 8220 apheresis-derived PCs) were tested at end day 3 their shelf life using system. initially reactive testing expired on also investigated by BacT/ALERT...
Summary Background Cow dust is one of the most important inducers occupational allergic diseases in Finland. For example, 1991 it accounted for almost 40% new asthma cases. Objective This study compares performance purified major cow allergen (BDA20) and crude bovine epithelial extract (BEA) diagnostic tests examines role milk allergy‐associated proteins (bovine serum albumin, α‐lactalbumin, β‐lactoglobulin, casein) respiratory allergy. Methods The humoral responses cow‐asthmatic healthy...
A new cell separator (COM.TEC, Fresenius) was recently developed aimed at efficient collection of WBC-reduced single-donor PLT concentrates (SDPs).Five German centers collected 554 SDPs with help the COM.TEC separator. Two multicenter counting studies were performed beginning and end study to document uniform results among participating centers.A total 441 (79.6%) collections included in according protocol. 342 single-dose 99 double-dose collected. For SDPs, an average blood volume 2826 +/-...
<b><i>Background and Aims:</i></b> Only little is known about blood groups other than ABO Rhesus factors in Arabian countries Iran. During the last years, increased migration to Central Europe has put a focus on question how guarantee supply for patients from these countries, particularly because hemoglobinopathies with need of regular support are more frequent that region. Therefore, group allele frequencies should be determined individuals Iran by molecular typing...
Automated collection of blood components with a cell separator (MCS 3p, Haemonetics), was performed according to three protocols.The first protocol provided 2 units fresh-frozen plasma (FFP); and one buffy coat-poor red (RBC) concentrate in additive solution. The second included an additional in-line filtration the RBC closed system after storage at 4 degrees C for 24 hours. In third protocol, platelet (PC) recovered from coat. Cell counts biochemical characterization RBCs (n = 20 each) were...
The immunological characteristics of an important group animal-derived allergens, lipocalins, are poorly known. To explore the immunology lipocalin allergen Bos d 2, several mouse strains with different H-2 haplotypes were immunized allergen. Only BALB/c mounted a distinct humoral response against 2. proliferative spleen cell responses all remained very weak. Further experiments mice confirmed that 2 is weak inducer both and cellular responses, weaker than control antigens hen egg lysozyme...
Exposure to non-matching human platelet alloantigens (HPA) may result in alloimmunization. Antibodies HPA can be responsible for post-transfusion purpura, refractoriness donor platelets, and fetal neonatal alloimmune thrombocytopenia. For the supply of compatible apheresis concentrates, genotypes are determined a routine manner.Here, we describe novel method genotyping twelve different systems simultaneously, including HPA-1 HPA-5, HPA-9w, HPA-10w, HPA-16w, HPA-19w, HPA-27w, HPA-34w by means...