A5019088372- Cannabis and Cannabinoid Research
- Pancreatic function and diabetes
- Alcohol Consumption and Health Effects
- Thyroid and Parathyroid Surgery
- Child Nutrition and Water Access
- Thyroid Cancer Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- Thyroid Disorders and Treatments
- Airway Management and Intubation Techniques
- Climate Change and Health Impacts
- Pharmacogenetics and Drug Metabolism
- Lipid metabolism and biosynthesis
- Natural Antidiabetic Agents Studies
- Liver Disease Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Endoplasmic Reticulum Stress and Disease
- Parathyroid Disorders and Treatments
- Drug-Induced Hepatotoxicity and Protection
- PI3K/AKT/mTOR signaling in cancer
- Voice and Speech Disorders
- Neuroendocrine Tumor Research Advances
- Cassava research and cyanide
- Infant Nutrition and Health
- Sleep and Wakefulness Research
- Peroxisome Proliferator-Activated Receptors
Kagawa University
2016-2024
International Centre for Diarrhoeal Disease Research
2019-2024
McGowan Institute for Regenerative Medicine
2022-2023
University of Pittsburgh
2021-2023
Madras Medical College
2015-2021
The endocannabinoid system is involved in signal transduction mammals. It comprises principally G protein-coupled cannabinoid receptors and their endogenous agonists, called endocannabinoids, as well the enzymes transporters responsible for metabolism of endocannabinoids. Two arachidonic acid–containing lipid molecules, arachidonoylethanolamide (anandamide) 2-arachidonoylglycerol, function N-acylethanolamines monoacylglycerols, which acid chain replaced with a saturated or monounsaturated...
Abstract Background We evaluated the impact of low-cost water, sanitation, and handwashing (WSH) child nutrition interventions on enteropathogen carriage in WASH Benefits cluster-randomized controlled trial rural Bangladesh. Methods analyzed 1411 routine fecal samples from children 14 ± 2 months old WSH (n = 369), counseling plus lipid-based nutrient supplement 353), 360), control 329) arms for 34 enteropathogens using quantitative polymerase chain reaction. Outcomes included number...
Background A number of studies have detected relationships between weather and diarrhea. Few investigated associations with specific enteric pathogens. Understanding pathogen-specific is crucial to inform public health in low-resource settings that are especially vulnerable climate change. Objectives Our objectives were identify environmental risk factors associated diarrhea enteropathogen prevalence young children rural Bangladesh, a population high diarrheal disease burden vulnerability...
We hypothesized that drinking water, sanitation, handwashing (WSH), and nutritional interventions would improve environmental enteric dysfunction (EED), a potential contributor to stunting.Within subsample of cluster-randomized, controlled trial in rural Bangladesh, we enrolled pregnant women 4 arms: control, WSH, child nutrition counseling plus lipid-based nutrient supplements (N), WSH (N+WSH). Among the birth cohort, measured biomarkers gut inflammation (myeloperoxidase, neopterin),...
The phospholipase A and acyltransferase (PLAAT) family is composed of three isoforms in mice (PLAAT1, 3, 5), all which function as phospholipid-metabolizing enzymes exhibiting A1 /A2 activities. Plaat3-deficient (Plaat3-/- ) were previously reported to show lean phenotype remarkable hepatic fat accumulation under high-fat diet (HFD) feeding, while Plaat1-/- have not been analyzed. In the present study, we generated investigated effects PLAAT1 deficiency on HFD-induced obesity, lipid...
N-Acylphosphatidylethanolamines (NAPEs) are a class of glycerophospholipids, which known as precursors for different bioactive N-acylethanolamines. We previously reported that phospholipase A/acyltransferase-1 (PLAAT-1), was originally found in mammals tumor suppressor, catalyzes N-acylation phosphatidylethanolamines to form NAPEs. However, recent online database suggested the presence an uncharacterized isoform PLAAT-1 with extra sequence at N terminus. In present study, we examined...
Arachidonylethanolamide (anandamide) acts as an endogenous ligand of cannabinoid receptors, while other N-acylethanolamines (NAEs), such palmitylethanolamide and oleylethanolamide, show analgesic, anti-inflammatory, appetite-suppressing effects through receptors. In mammalian tissues, NAEs, including anandamide, are produced from glycerophospholipid via N-acyl-phosphatidylethanolamine (NAPE). The ɛ isoform cytosolic phospholipase A2 (cPLA2) functions N-acyltransferase to form NAPE. Since the...
Abstract Background Understanding pathogen-specific relationships with climate is crucial to informing interventions under change. Methods We matched spatiotemporal temperature, precipitation, surface water, and humidity data from a trial in rural Bangladesh that measured diarrhea enteropathogen prevalence children 0-2 years 2012-2016. fit generalized additive models estimated percent changes using projected precipitation Shared Socio-Economic pathways describing sustainable development...
N-Acyl-phosphatidylethanolamines (NAPEs) represent a class of glycerophospholipids and serve as the precursors bioactive N-acylethanolamines, including arachidonoylethanolamide (anandamide), palmitoylethanolamide oleoylethanolamide. NAPEs are produced in mammals by N-acyltransferases, enzymes which transfer an acyl chain to amino group phosphatidylethanolamine. Recently, ɛ isoform cytosolic phospholipase A2 (cPLA2ɛ, also called PLA2G4E) was identified Ca2+-dependent N-acyltransferase. We...
Methimazole (MMI) is a widely used antithyroid drug, but it can cause hepatotoxicity by unknown mechanisms. Previous studies showed that the hepatic metabolism of MMI produces N-methylthiourea, leading to liver damage. However, specific enzyme responsible for production toxic metabolite N-methylthiourea still unclear. In this study, we screened cytochromes P450 (CYPs) in from MMI. CYP2A6 was identified as key catalyzing produce N-methylthiourea. When mice were pretreated with inhibitor,...
Background: Thyroid disease has myriad manifestations. stimulating hormone (TSH) and a paired determination of TSH freeT4 would add to find out the degree dysfunction with overutilization thyroid function tests (TFT’s) as symptoms are being overseen in recent days. The objectives present study were validate clinical symptom scoring index for disorders using FT4.Methods: consisting 20 parameters was given 110 patients presenting our outpatient department new onset thyroid-related complaints...
Hypomagnesemia is known to impede hypocalcemia correction. This prospective observational study aimed evaluate the impact of serum magnesium levels on development refractory hypocalcemia, which remains a concerning problem after total thyroidectomy (TT).Consecutive subjects (n = 312; mean age 38.4 [range: 13-83] years; M:F 62:250) undergoing TT for benign or malignant thyroid diseases were evaluated corrected-calcium (8.4-10.4 mg/dL), (1.7-2.4 intact parathormone (iPTH), and...
Primary hyperparathyroidism is detected in the Western world an asymptomatic stage due to routine calcium screening. In India, patients are still diagnosed with various symptoms such as bone disease and renal only 5.6% stage. A 48-year-old female came complaints of right hip pain 1-month duration. She had low back a year ago radiating both thighs. The was not suggestive inflammatory arthritis, autoimmune profile negative. progressively worsened, patient became bedridden. General examination...