A5003451072- Forensic and Genetic Research
- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Identification and Quantification in Food
- Molecular Biology Techniques and Applications
- Mitochondrial Function and Pathology
- Forensic Anthropology and Bioarchaeology Studies
- Animal Virus Infections Studies
- Fractal and DNA sequence analysis
- Animal Ecology and Behavior Studies
- Archaeology and ancient environmental studies
- Race, Genetics, and Society
- COVID-19 Clinical Research Studies
- Virus-based gene therapy research
- Metabolism and Genetic Disorders
- Thyroid Disorders and Treatments
- Viral gastroenteritis research and epidemiology
- Congenital limb and hand anomalies
- Advanced Thermoelectric Materials and Devices
- Machine Learning in Bioinformatics
- Mosquito-borne diseases and control
- Dental Research and COVID-19
- Food, Nutrition, and Cultural Practices
- Long-Term Effects of COVID-19
- Advanced Thermodynamic Systems and Engines
University of Minho
2019-2022
KU Leuven
2022
Israel Institute for Biological Research
2022
Universidade do Porto
2008-2017
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2015-2017
IPO Porto
2004-2017
The advent of complete mitochondrial DNA (mtDNA) sequence data has ushered in a new phase human evolutionary studies. Even quite limited volumes mtDNA can now be used to identify the critical polymorphisms that define sub-clades within an haplogroup, providing springboard for large-scale high-resolution screening mtDNAs. This strategy past been applied haplogroup V, which represents <5% European Here we adopted similar approach H, by far most common at lower resolution displayed rather...
Inbred mouse strains have been maintained for more than 100 years, and they are thought to be a mixture of four different subspecies. Although genealogies established, female inbred phylogenies remain unexplored. By phylogenetic analysis newly generated complete mitochondrial DNA sequence data in 16 strains, we show here that all common descend from the same Mus musculus domesticus wild ancestor, suggest present evolutionary process their relatives with faster accumulation replacement...
Previous genetic, anthropological and linguistic studies have shown that Roma (Gypsies) constitute a founder population dispersed throughout Europe whose origins might be traced to the Indian subcontinent. Linguistic evidence point Indo-Aryan ethnic groups from North-western India as ancestral parental of Roma. Recently, strong genetic hint supporting this theory came study private mutation causing primary congenital glaucoma. In present study, complete mitochondrial control sequences...
Abstract Background Use of immunosuppressive or immunomodulatory therapies (IITs) may be a risk factor for severe COVID-19 outcomes. The INFORM (INvestigation oF cOvid-19 Risk among iMmunocompromised populations) study (ISRCTN53375662) uses routinely collected, national primary/secondary care data in England to provide comprehensive, population-based assessment impact, risk, and cost immunocompromised (IC) other high-risk populations. Here we assess hospitalization IC individuals receiving...
Abstract The first large‐scale fine characterization of Tunisian H lineages clarifies that the post‐Last glacial maximum expansion originating in Iberia not only led to resettlement Europe but also North Africa. We found 46% 81 subscreened for 1,580 bp mtDNA coding region were affiliated with H1 and H3 subhaplogroups, which are known have originated Iberia. Although no signs local detected, would allow a clear dating their introduction, younger less diverse indicate as radiating centre....
Mitochondrial DNA (mtDNA) population data for forensic purposes are still scarce some populations, which may limit the evaluation of evidence especially when rarity a haplotype needs to be determined in database search. In order improve collection mtDNA lineages from Iberian and South American subcontinents, we here report results collaborative study involving nine laboratories Spanish Portuguese Speaking Working Group International Society Forensic Genetics (GHEP-ISFG) EMPOP. The individual...
Genetic diversity of present American populations results from very complex demographic events involving different types and degrees admixture. Through the analysis lineage markers such as mtDNA Y chromosome it is possible to recover original Native haplotypes, which remained identical since admixture due absence recombination. However, decrease in effective population sizes consequent genetic drift effects suffered by these during European colonization resulted loss or under-representation...
Summary A mitochondrial DNA (mtDNA) haplogroup association study carried out in 101 southern Portuguese males with oligozoospermia showed to be negative when comparing a geographically matching control sample. Misleading positive signs were however obtained using other samples from the same country. This shows that mtDNA population substructure can also introduce spurious studies, as previously reported for Y‐chromosome. However, our data do not exclude probability particular mutation...
Next-generation sequencing (NGS) has been proven to address some of the limitations current testing methods for adventitious virus detection in biologics. The International Alliance Biological Standardization (IABS), U.S. Food and Drug Administration (FDA), European Directorate Quality Medicines Healthcare (EDQM) co-organized "3rd Conference on Sequencing Adventitious Virus Detection Biologics Humans Animals", which was held September 27-28, 2022, Rockville, Maryland, U.S.A. meeting gathered...
The vast majority of methods available for sequence comparison rely on a first alignment step, which requires number assumptions evolutionary history and is sometimes very difficult or impossible to perform due the abundance gaps (insertions/deletions). In such cases, an alternative alignment-free method would prove valuable. Our starts by computation generalized suffix tree all sequences, completed in linear time. Using this tree, frequency possible words with preset length L-L-words--in...