A5001990947- Malaria Research and Control
- Mosquito-borne diseases and control
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- COVID-19 Clinical Research Studies
- Allergic Rhinitis and Sensitization
- Tuberculosis Research and Epidemiology
- Food Allergy and Anaphylaxis Research
- Vector-borne infectious diseases
- Dengue and Mosquito Control Research
- Autoimmune Bullous Skin Diseases
- Computational Drug Discovery Methods
- Eosinophilic Disorders and Syndromes
- Long-Term Effects of COVID-19
- Blood disorders and treatments
- Antifungal resistance and susceptibility
- COVID-19 and Mental Health
- SARS-CoV-2 and COVID-19 Research
- Infectious Diseases and Mycology
- Dermatology and Skin Diseases
- Mast cells and histamine
- HIV/AIDS drug development and treatment
- Syphilis Diagnosis and Treatment
- COVID-19 diagnosis using AI
- Drug Transport and Resistance Mechanisms
Columbia University Irving Medical Center
2024
Harvard University
2020-2023
Harvard Global Health Institute
2022
National Institute of Allergy and Infectious Diseases
2018-2021
National Institutes of Health
2018-2021
Infectious Disease Research Institute
2020
University of North Carolina at Chapel Hill
2017-2019
Office of Infectious Diseases
2016-2017
Duke Institute for Health Innovation
2016
Duke University
2016
The COVID-19 pandemic has sparked unprecedented public health and social measures (PHSM) by national local governments, including border restrictions, school closures, mandatory facemask use stay at home orders. Quantifying the effectiveness of these interventions in reducing disease transmission is key to rational policy making response current future pandemics. In order estimate interventions, detailed descriptions their timelines, scale scope are needed. Health Intervention Tracking for...
Significance Artemisinin-based combination therapies (ACTs) are first-line antimalarial used worldwide. The artemisinin drug (ART) component clears the bulk of infection rapidly, but small numbers persistent parasites must be removed by partner drug. Longer parasite clearance t 1/2 values have been associated with a Kelch-propeller mutation (K13 C580Y), raising concerns increased ART resistance. We investigated effects C580Y using Plasmodium falciparum cross and monkey malaria model....
Although gametocytes are essential for malaria transmission, in Africa many falciparum-infected persons without smear-detectable still infect mosquitoes. To see whether the same is true Southeast Asia, we determined infectiousness of 119 Cambodian adults to Anopheles dirus mosquitoes by membrane feeding. Just 5.9% subjects infected The 8.4% patients with were >20 times more likely than those and source 96% all mosquito infections. In low-transmission settings, targeting transmission-blocking...
Artemisinin and its semisynthetic derivatives (ART) are fast acting, potent antimalarials; however, their use in malaria treatment is frequently confounded by recrudescences from bloodstream Plasmodium parasites that enter into later reactivate a dormant persister state. Here, we provide evidence the mitochondria of dihydroartemisinin (DHA)-exposed persisters dramatically altered enlarged relative to young, actively replicating ring forms. Restructured mitochondrial-nuclear associations an...
Background Single low dose primaquine (SLD PQ, 0.25mg/kg) is recommended in combination with artemisinin-based therapy (ACT) as a gametocytocide to prevent Plasmodium falciparum transmission areas threatened by artemisinin resistance. To date, no randomized controlled trials have measured primaquine's effect on infectiousness Anopheline mosquitoes Southeast Asia. Methods Cambodian adults uncomplicated malaria were receive single 45mg of (equivalent three SLD PQ) or after the third...
Some Kelch mutations of the Plasmodium falciparum K13 protein confer increased survival to dihydroartemisinin (DHA)-treated ring-stage parasites. Here, we asked if affect a dormancy phenotype allowing parasites survive DHA exposure and then sorbitol selection. Although recrudescence from differed between two distinct parasite lines, it was similar for isogenic lines carrying single-site substitutions in K13. Therefore, do not alter DHA-sorbitol combined phenotype; rather, traits other loci...
Microbial larviciding may be a potential supplement to conventional malaria vector control measures, but scant information on its relative implementation costs and effectiveness, especially in rural areas, is an impediment expanding uptake. We perform costing analysis of seasonal microbial programme Tanzania.We evaluated the financial economic from perspective public provider 3-month, community-based intervention implemented twelve villages Mvomero District Tanzania 2012-2013. Cost data were...
Lumefantrine and mefloquine are used worldwide in artemisinin-based combination therapy (ACT) of malaria. Better understanding drug susceptibility resistance is needed can be obtained from studies genetic crosses. Drug response phenotypes a cross between Plasmodium falciparum lines 803 (Cambodia) GB4 (Ghana) were as half-maximal effective concentrations (EC50s) days to recovery (DTR) after 24 h exposure 500 nM lumefantrine. EC50s mefloquine, halofantrine, chloroquine, dihydroartemisinin also...
Background Tuberculosis (TB), human immunodeficiency virus (HIV), and hepatitis C (HCV) share a global presence propensity to disproportionately affect marginalized populations. However, over recent decades, many fewer drugs have been brought market for TB than the others. Although three new anti-TB approved in US or Europe last 10 years, uptake of these has limited. Using case examples developed recently TB, HIV, HCV, we explore possible reasons. We examine use effect regulatory pathways...
Abstract Background In Southeast Asia, people are often coinfected with different species of malaria (Plasmodium falciparum [Pf] and Plasmodium vivax [Pv]) as well multiple clones the same species. Whether particular or within mixed infections more readily transmitted to mosquitoes remains unknown. Methods Laboratory-reared Anopheles dirus were fed on blood from 119 Pf-infected Cambodian adults, 5950 dissected evaluate for infection. Among 12 persons who infected mosquitoes, polymerase chain...
Abstract Paracoccidioidomycosis is a dimorphic fungal infection endemic in Latin America. We report patient with history of pulmonary paracoccidioidomycosis who presented relapsed disease the central nervous system 4 years after initial treatment. review current treatment strategies for and neuroparacoccidioidomycosis.
ABSTRACT Artemisinin and its semi-synthetic derivatives (ART) are fast acting, potent antimalarials; however, their use in malaria treatment is frequently confounded by recrudescences from bloodstream Plasmodium parasites that enter into later reactivate a dormant persister state. Here we provide evidence the mitochondria of dihydroartemisinin (DHA)-exposed persisters dramatically altered enlarged relative to young, actively replicating ring forms. Restructured mitochondrial-nuclear...
Abstract Background Few studies have examined the burden of postacute sequelae coronavirus disease 2019 (COVID-19) (PASC) in low- and middle-income countries. We sought to characterize PASC with self-reported questionnaires clinical examinations end-organ function Lima, Peru. Methods From January July 2021, we recruited participants at least 8 weeks after COVID-19 diagnosis from a case registry evaluated for questionnaires, neuropsychiatric evaluations, chest X-ray, spirometry,...
Erythema multiforme is a reactive mucocutaneous disorder which an acute, self-limiting, inflammatory characterized by degrees of blistering and ulceration. This created hypersensitivity reaction triggered certain infection, medication , food additives or chemicals. We report case erythema managed with prophylactic valacyclovir systemic corticosteroid. An 47 years old female patients had lesions in the oral cavity, lips, hand ear been diagnosed as minor. was not related to drug intake; it...