A5001662277- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Air Quality and Health Impacts
- COVID-19 Clinical Research Studies
- Nail Diseases and Treatments
- Vibrio bacteria research studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Use and Resistance
- Heavy Metal Exposure and Toxicity
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Resistance in Bacteria
- Plant Pathogens and Fungal Diseases
- Childhood Cancer Survivors' Quality of Life
- Engineering and Technology Innovations
- Long-Term Effects of COVID-19
- Marine Bivalve and Aquaculture Studies
- Human Health and Disease
- Environmental Justice and Health Disparities
- Infection Control in Healthcare
- Surgical site infection prevention
- Cutaneous lymphoproliferative disorders research
- Healthcare Systems and Reforms
- Climate Change and Health Impacts
- Cardiac Structural Anomalies and Repair
- Global Public Health Policies and Epidemiology
Washington University in St. Louis
2022-2025
Honduras Foundation for Agricultural Research
2018-2024
University of Michigan
2020-2024
Polytechnic University of the Philippines
2024
Michigan United
2021
Universidad Católica de Honduras Nuestra Señora Reina de la Paz
2016-2020
Environmental Protection Agency
1998-2011
National Center for Environmental Assessment (EPA)
2011
Abstract Background The dimorphic mycoses (DMs) of the United States—Histoplasma, Coccidioides, and Blastomyces—commonly known as endemic North America (in addition to Paracoccidioides) are increasingly being diagnosed outside their historical areas endemicity. Despite this trend, maps outlining geographic distributions have not been updated in more than half a century using large, nationwide database containing individual-patient–level data. Methods This was retrospective analysis...
The COVID-19 pandemic has sparked unprecedented public health and social measures (PHSM) by national local governments, including border restrictions, school closures, mandatory facemask use stay at home orders. Quantifying the effectiveness of these interventions in reducing disease transmission is key to rational policy making response current future pandemics. In order estimate interventions, detailed descriptions their timelines, scale scope are needed. Health Intervention Tracking for...
Abstract Background There are few data on the full spectrum of disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection across lifespan from community-based or nonclinical settings. Methods We followed 2338 people in Managua, Nicaragua, aged <94 years March 2020 through 2021. SARS-CoV-2 was identified real-time reverse transcription polymerase chain reaction (RT-PCR) enzyme-linked immunosorbent assay. Disease presentation assessed at time...
Abstract Background An association between coronavirus disease 2019 (COVID-19)–associated invasive fungal infections (CAIFIs) and high mortality among intubated patients has been suggested in previous research. However, some of the current evidence was derived from small case series multicenter studies conducted during different waves COVID-19 pandemic. We examined incidence CAIFIs their associated using a large, database built throughout Methods retrospective analysis National COVID Cohort...
Abstract Background Climate change is anticipated to have profound effects on human health including infectious diseases. Wildfires increased in frequency and intensity due changes precipitation been linked worsening respiratory infections. We aimed demonstrate whether an association existed between wildfire smoke COVID-19 California during 2020. Demographic data by county based the 2020 American Census Survey New York Times mask-use survey conducted July The population of generally higher...
Dengue is recognized as a major health issue in large urban tropical cities but also observed rural areas. In these environments, physical characteristics of the landscape and sociodemographic factors may influence vector populations at small geographic scales, while prior immunity to four dengue virus serotypes affects incidence. 2019, northwestern Ecuadorian community, only accessible by river, experienced outbreak. The village 2-3 hours boat away from nearest population center comprises...
Histoplasmosis and cryptococcosis are important public health problems in people living with HIV (PLHIV) Central America. Conventional laboratory assays, based on microscopy culture, not optimal for the diagnosis of either disease. However, antigen (Ag) assays rapid highly accurate these infections.Laboratory surveillance PLHIV was carried out four hospitals Panama, Honduras Nicaragua, between 2015 2019. Detection Histoplasma antigens urine performed by enzyme immunoassay (EIA), Cryptococcus...
Abstract Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused substantial morbidity and mortality worldwide. Few reports exist in Latin America, a current epicenter of transmission. Here, we aim to describe the epidemiology outcomes associated with disease 2019 (COVID-19) Honduras. Methods Baseline clinical epidemiological information SARS-CoV-2 reverse transcriptase polymerase chain reaction–confirmed cases detected between 17 March–4 May San Pedro...
Although Acinetobacter baumannii has become one of the most important nosocomial pathogens worldwide, very little is known about genetic identity isolates from less developed countries in Latin America. To alleviate this, we sequenced genomes 16 A. Honduras. Whole-genome sequencing was conducted on five Honduran Hospitals. With sequences these and other 42 publically available genomes, a maximum likelihood phylogeny constructed to establish relationship between those belonging International...
Acinetobacter baumannii is considered to be a worldwide threat public health due its high antimicrobial resistance rates and the severe infections it can cause. Little known about this pathogen's in Central America. This report aims describe profile of A. at tertiary hospital Honduras. The cross-sectional analysis was conducted care laboratory San Pedro Sula 2015 - 2017. A total 113 consecutive microbiological reports were analyzed, comprising 100 individuals from whom isolated....
Evidence-based interventions often need to be adapted maximize their implementation potential in low-to middle-income countries. A single-arm feasibility study was conducted determine the and acceptability of a telephone-delivered, nurse-led, symptom management intervention for adults undergoing chemotherapy Honduras. Over course 6 months, nurses engaged 25 patients intervention. Each participant received an average 16.2 attempts contact them telephone sessions ( SD = 8.0, range 2-28)....
To evaluate the feasibility of brigade-style, multiphasic cancer screening in Honduras, exploring data from 3 events that each tested for multiple cancers on single occasions.This series studies used a single-arm, post-test-only design to explore implementing multiphasic, community-based at same rural location 2013, 2016, and 2017. The 2013 event women screened 2 (breast cervix), 2016 (breast, cervix, thyroid). 2017 men 5 (skin, prostate, colorectal, oropharynx, testes).Totals 473 401...
Cryptococcal meningitis is a major cause of death among people with human immunodeficiency virus (PWH). antigen (CrAg) testing asymptomatic patients an important public health measure to reduce mortality in high-incidence areas. However, limited data exist on CrAg prevalence Central America. We conducted prospective cohort study at the 2 largest (HIV) clinics and hospitals Honduras. serum cerebrospinal fluid was performed individuals HIV who had CD4 ≤100 cells/mm3 between 2017 2018. After...
BackgroundThe COVID-19 pandemic has had a severe impact on the Latin American subcontinent, particularly in areas with limited hospital resources and restricted Intensive Care Unit (ICU) capacity. This study aimed to provide comprehensive description of clinical characteristics, outcomes, factors associated survival hospitalized patients Honduras.Research questionWhat were characteristics outcomes large referral center Honduras?Study design methodsThis employed retrospective cohort conducted...
Itraconazole is the treatment of choice for many fungal infections, including histoplasmosis. While tolerability itraconazole has been described in short-term trial settings, there are few studies on side effects during long-term therapy. Fluconazole, which usually thought to be less toxic, associated with 52% toxicity treatment. To determine frequency, types, and timing from therapy, resulting changes plans, associations between patient characteristics serum levels effect status. We...
Histoplasmosis is an important infection among transplant recipients. Few studies have described its epidemiology and outcomes in the modern era.
Abstract Background The dimorphic mycoses (DM) histoplasmosis, blastomycosis, and coccidioidomycosis are classically thought to be geographically restricted specific regions of the United States. current scientific consensus is that these geographic boundaries expanding, but extent this expansion remains uncertain. Methods This study a retrospective analysis >21 million (annually) commercially insured individuals within States during 2007-2016. Diagnosis coccidioidomycosis,...
Background: Occupational exposure to agrochemicals, some of which are known or suspected carcinogens, is a major health hazard for subsistence agricultural workers and their families. These impacts more prevalent in low-and-middle income countries (LMICs) due weak regulations, lack awareness the risks contamination, general personal protective equipment (PPE), low literacy about proper agrochemical application techniques. Fluorescent tracer dyes have been described as means visualizing...
P-453 Introduction: Children’s exposure changes with developmental stages due to in their environment and differences behaviour physiology. Children may consume more of certain foods, drink water, have higher inhalation rates per body weight than adults. For example, consumption apples by children between birth 5 months age is about 19 g/kg-day, while adults 20 years older approximately 2 almost a 10-fold difference. (e.g., mouthing objects surfaces) also put them at risk from environmental...